Electrochemical oxidation of mitoxantrone at a glassy carbon electrode

Abstract

Mitoxantrone is an anthracycline used as an antitumour antibiotic for leukaemia and breast cancer treatment, due to its interaction with DNA. However, the molecular mechanism of the antitumour action is not completely understood. Using a glassy carbon electrode the electrochemical oxidation of mitoxantrone was shown to be a complex, pH-dependent, irreversible electrode process involving several metabolites. Comparison of the electrochemical oxidation behaviour of mitoxantrone, ametantrone and aminantrone enabled a deeper understanding of the mechanism and showed the relevance of electrochemical data for the understanding of the cytotoxicity of mitoxantrone. Since mitoxantrone and its oxidation products adsorb strongly on the electrode surface, causing severe problems of electrode fouling, reproducible electroanalytical determinations could only be done at very low concentrations and in an aqueous buffer supporting electrolyte containing 30% ethanol. The detection limit obtained was 10 À7 M. #

An implantable bio-micro-system for drug monitoring

“…The measured oxidation current peak location and value has less than 7% discrepancy between our microsystem and the Autolab potentiostat. The peak positions are consistent with the literature [15], [16].…”

Interaction of anticancer drug mitoxantrone with DNA analyzed by electrochemical and spectroscopic methods

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Adsorption and Electrooxidation of DNA at Glassy Carbon Paste Electrodes

“…Pang et al (1996) have reported the immobilization of nucleic acids on oxidized surfaces of glassy carbon electrodes (GCE) by deposition of the DNA solution and further evaporation of the solvent. Several studies La-Scalea 1997a, 1997b;Oliveira Brett, Serrano, Gutz, La-Scalea, and Cruz 1997;Oliveira Brett et al 1999) have demonstrated the successful use of glassy carbon as substrate for preparing DNA modified electrodes to evaluate the voltammetric behavior of nitroimidazoles. Oliveira Brett et al (2004) have also proposed the detection of all deoxyribonucleotides at adequately conditioned GCE.…”