Electrochemical nanobiosensor for early detection of rheumatoid arthritis biomarker: Anti- cyclic citrullinated peptide antibodies based on polyaniline (PANI)/MoS2-modified screen-printed electrode with PANI-Au nanomatrix-based signal amplification

Selvam, Sathish Panneer; Chinnadayyala, Somasekhar R.; Cho, Sungbo

doi:10.1016/j.snb.2021.129570

Cited by 25 publications

(8 citation statements)

References 47 publications

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“…The experimental results showed that the sensor response increased linearly with the stepwise increase of the biomarker concentration. A polyaniline (PANI)/MoS2-modified screen-printed electrode was detected for anti-cyclic citrullinated peptide [125]. Among them, the polymerized PANI-Au nanomatrix was utilized to entrap the aCCP antibodies for amplification of the higher signal.…”

Section: Detection Of Other Analytes and Chemicalsmentioning

confidence: 99%

A Review on Microfluidics-Based Impedance Biosensors

et al. 2023

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Electrical impedance biosensors are powerful and continuously being developed for various biological sensing applications. In this line, the sensitivity of impedance biosensors embedded with microfluidic technologies, such as sheath flow focusing, dielectrophoretic focusing, and interdigitated electrode arrays, can still be greatly improved. In particular, reagent consumption reduction and analysis time-shortening features can highly increase the analytical capabilities of such biosensors. Moreover, the reliability and efficiency of analyses are benefited by microfluidics-enabled automation. Through the use of mature microfluidic technology, complicated biological processes can be shrunk and integrated into a single microfluidic system (e.g., lab-on-a-chip or micro-total analysis systems). By incorporating electrical impedance biosensors, hand-held and bench-top microfluidic systems can be easily developed and operated by personnel without professional training. Furthermore, the impedance spectrum provides broad information regarding cell size, membrane capacitance, cytoplasmic conductivity, and cytoplasmic permittivity without the need for fluorescent labeling, magnetic modifications, or other cellular treatments. In this review article, a comprehensive summary of microfluidics-based impedance biosensors is presented. The structure of this article is based on the different substrate material categorizations. Moreover, the development trend of microfluidics-based impedance biosensors is discussed, along with difficulties and challenges that may be encountered in the future.

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Section: Detection Of Other Analytes and Chemicalsmentioning

confidence: 99%

A Review on Microfluidics-Based Impedance Biosensors

et al. 2023

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“…In this context, an electrochemical immunosensor was prepared using screen-printed electrodes modified with poly(aniline) (PANI) and MoS 2 . A citrulline-containing cyclic filaggrin peptide (21-mer) to explicitly recognize anti-CCP antibody was covalently attached to this surface, and a sandwich-type immunoassay was established with anti-CCP trapped in an interfacial polymerized PANI-AuNPs for signal amplification [ 114 ]. Using SWV, the achieved LOD value was 0.16 IU mL −1 anti-CCP.…”

Section: Oral Microbiomementioning

confidence: 99%

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Sánchez‐Tirado

Agüı́

González‐Cortés

et al. 2023

Sensors

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The study of the human microbiome is a multidisciplinary area ranging from the field of technology to that of personalized medicine. The possibility of using microbiota biomarkers to improve the diagnosis and monitoring of diseases (e.g., cancer), health conditions (e.g., obesity) or relevant processes (e.g., aging) has raised great expectations, also in the field of bioelectroanalytical chemistry. The well-known advantages of electrochemical biosensors—high sensitivity, fast response, and the possibility of miniaturization, together with the potential for new nanomaterials to improve their design and performance—position them as unique tools to provide a better understanding of the entities of the human microbiome and raise the prospect of huge and important developments in the coming years. This review article compiles recent applications of electrochemical (bio)sensors for monitoring microbial metabolites and disease biomarkers related to different types of human microbiome, with a special focus on the gastrointestinal microbiome. Examples of electrochemical devices applied to real samples are critically discussed, as well as challenges to be faced and where future developments are expected to go.

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“…In this context, an electrochemical immunosensor was prepared using screen-printed electrodes modified with poly(aniline) (PANI) and MoS2. A citrulline-containing cyclic filaggrin peptide (21-mer) to explicitly recognize anti-CCP antibody was covalently attached to this surface, and a sandwich-type immunoassay was established with anti-CCP trapped into an interfacial polymerized PANI-AuNPs for signal amplification [112]. Using SWV, the achieved LOD value was 0.16 IU mL -1 anti-CCP.…”

Section: Oral Microbiomementioning

confidence: 99%

Electrochemical (Bio)Sensing Devices for Human Microbiome Related Biomarkers

Sánchez‐Tirado¹,

Agüı́²,

González‐Cortés³

et al. 2022

Preprint

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The study of the human microbiome is a multidisciplinary area that affects from the field of technology to that of personalized medicine. The possibility of using microbiota biomarkers for the improvement in the diagnosis and monitoring of diseases (e.g. cancer), health conditions (e.g. obesity) or clinical parameters (e.g. ageing) has aroused great expectations, also in the scope of bio-electroanalytical chemistry. The well-known advantages of electrochemical transduction: high sensitivity, rapid response and possibility of miniaturization, together with the potential of new nanomaterials to improve both the design of electrode platforms and the performance of the resulting electrochemical biosensors make presumably a huge development in the next few years providing a better understanding of human microbiome entities. In this review article, the recent applications of electrochemical (bio)sensors for monitoring microbial metabolites and biomarkers of diseases related to different types of the human microbiome, with a special focus on the gastrointestinal microbiome, are reviewed. Examples of electrochemical devices applied to real samples are critically discussed as well as the challenges and prospects to be faced.

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Electrochemical nanobiosensor for early detection of rheumatoid arthritis biomarker: Anti- cyclic citrullinated peptide antibodies based on polyaniline (PANI)/MoS2-modified screen-printed electrode with PANI-Au nanomatrix-based signal amplification

Cited by 25 publications

References 47 publications

A Review on Microfluidics-Based Impedance Biosensors

A Review on Microfluidics-Based Impedance Biosensors

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Electrochemical (Bio)Sensing Devices for Human Microbiome Related Biomarkers

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