Electrochemical microfluidic chip based on molecular imprinting technique applied for therapeutic drug monitoring

Liu, Jiang; Yu, Zhang; Jiang, Min; Tian, Li; Sun, Shiguo; Zhao, Na; Zhao, Feng; Li, Yingchun

doi:10.1016/j.bios.2017.01.037

Cited by 62 publications

(26 citation statements)

References 32 publications

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“…The main advantage of co‐imprinting is that the virus nanostructure has a high surface area, which means a potentially higher number of binding molecules on the virus surface for SAM formation. The utility of this type of approach has been demonstrated for other types of 3D nanostructured MIPs including nickel nanospheres and doped graphene sheets . These modifications to the traditional imprinting approach (i.e.…”

Section: Figurementioning

confidence: 88%

“…The utility of this type of approach has been demonstrated for other types of 3D nanostructured MIPs including nickel nanospheresa nd doped graphene sheets. [17][18][19] These modifications to the traditional imprinting approach( i.e. template + polymer alone), termed molecularly co-imprinted polymers (MCIPs), have ah igher number of active sites for the templates in question, and display much improved sensitivity and specificity.…”

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confidence: 99%

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Small‐Molecule Dengue Virus Co‐imprinting and Its Application as an Electrochemical Sensor

et al. 2017

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Polymers can be synthesized to recognize small molecules. This is achieved by introducing the target molecule during monomer self‐assembly, where they can be incorporated during cross‐linking polymerization. Following additional pre‐processing, the material obtained can then be applied as a sensing layer for these molecules in many applications. The sensitivity of the polymers depends on the “active sites” imprinted on the surface. Increasing the number of active sites on the polymers surface can be achieved by using nanoparticles as a platform to support and concentrate the molecules for imprinting. In this work, we report the first use of dengue virus as a supporting nanoparticle to make for a more effective polymer composite sensor for the detection of bisphenol A (BPA), which is an environmental contaminant. The dengue virus has a nanoparticle size of around 100 nm and its surface provides regions where lipids and hydrophobic compounds can bind, making it an ideal support. The mixing of BPA with dengue prior to monomer self‐assembly led to imprinted polymer surfaces with much higher density BPA binding sites and a limit of detection of 0.1 pm. We demonstrate that a BPA–dengue co‐imprinting polymer composite sensor shows a very high sensitivity for BPA, but with lower production costs and technical requirements than other comparable methods.

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Section: Figurementioning

confidence: 88%

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confidence: 99%

Small‐Molecule Dengue Virus Co‐imprinting and Its Application as an Electrochemical Sensor

et al. 2017

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“…Recently, rapid diagnostic analysis, which is called point‐of‐care testing (POCT), has become a popular trend . A POCT diagnostic system can provide rapid in vitro diagnostic results for untrained personnel at the patient's bedside, as well as in operating rooms, outpatient clinics, and at accident sites .…”

mentioning

confidence: 99%

“…Meanwhile, obtaining accurate diagnoses for POCT is challenging in low‐resource settings. Microfluidic analytical systems have the advantages of high integration, miniaturization, and rapid responsiveness, which represent the most promising technology for satisfying the needs of POCT . The most common substrate materials for microfluidic chips mainly include paper, plastics, and silicon .…”

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confidence: 99%

Disposable Morpho menelaus Based Flexible Microfluidic and Electronic Sensor for the Diagnosis of Neurodegenerative Disease

Elbaz

Gao

et al. 2018

Adv Healthcare Materials

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Rapid early disease prevention or precise diagnosis is almost impossible in low-resource settings. Natural ordered structures in nature have great potential for the development of ultrasensitive biosensors. Here, motivated by the unique structures and extraordinary functionalities of ordered structures in nature, a biosensor based on butterfly wings is presented. In this study, a flexible Morpho menelaus (M. menelaus) based wearable sensor is integrated with a microfluidic system and electronic networks to facilitate the diagnosis of neurodegenerative disease (ND). In the microfluidic section, the structural characteristics of the M. menelaus wings up layer are combined with SiO nanoparticles to form a heterostructure. The fluorescent enhancement property of the heterostructure is used to increase the fluorescent intensity for multiplex detection of two proteins: IgG and AD7c-NTP. For the electronic section, conductive ink is blade-coated on the under layer of wings for measuring resistance change rate to obtain the frequency of static tremors of ND patients. The disposable M. menelaus based flexible microfluidic and electronic sensor enables biochemical-physiological hybrid monitoring of ND. The sensor is also amenable to a variety of applications, such as comprehensive personal healthcare and human-machine interaction.

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“…After polymerization, the templates are removed from the complex, and then "tailor-made" binding sites are formed for templates rebinding. Owing to their excellent physical/chemical stability and recognition properties, MIPs have been suggested to be a promising class of materials for sample preparation [14][15][16][17][18][19], bio/chemical sensors [19][20][21][22], mimetic enzyme catalysis, and so on [23]. Moreover, the introduction of magnetic nanoparticles into MIPs field has greatly expanded the application of MIPs in sample preparation.…”

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confidence: 99%

Facile preparation of magnetic molecularly imprinted polymers for the selective extraction and determination of dexamethasone in skincare cosmetics using HPLC

Zhang

Guo

et al. 2018

J of Separation Science

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Dexamethasone-imprinted polymers were fabricated by reversible addition-fragmentation chain transfer polymerization on the surface of magnetic nanoparticles under mild polymerization conditions, which exhibited a narrow polydispersity and high selectivity for dexamethasone extraction. The dexamethasone-imprinted polymers were characterized by scanning electron microscopy, transmission electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction, energy dispersive spectrometry, and vibrating sample magnetometry. The adsorption performance was evaluated by static adsorption, kinetic adsorption and selectivity tests. The results confirmed the successful construction of an imprinted polymer layer on the surface of the magnetic nanoparticles, which benefits the characteristics of high adsorption capacity, fast mass transfer, specific molecular recognition, and simple magnetic separation. Combined with high-performance liquid chromatography, molecularly imprinted polymers as magnetic extraction sorbents were used for the rapid and selective extraction and determination of dexamethasone in skincare cosmetic samples, with the accuracies of the spiked samples ranging from 93.8 to 97.6%. The relative standard deviations were less than 2.7%. The limit of detection and limit of quantification were 0.05 and 0.20 μg/mL, respectively. The developed method was simple, fast and highly selective and could be a promising method for dexamethasone monitoring in cosmetic products.

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Electrochemical microfluidic chip based on molecular imprinting technique applied for therapeutic drug monitoring

Cited by 62 publications

References 32 publications

Small‐Molecule Dengue Virus Co‐imprinting and Its Application as an Electrochemical Sensor

Small‐Molecule Dengue Virus Co‐imprinting and Its Application as an Electrochemical Sensor

Disposable Morpho menelaus Based Flexible Microfluidic and Electronic Sensor for the Diagnosis of Neurodegenerative Disease

Facile preparation of magnetic molecularly imprinted polymers for the selective extraction and determination of dexamethasone in skincare cosmetics using HPLC

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