Electrochemical method of pyrophosphate determination by quinone reduction

Xu, Weiwei; Shao, Cuimin; Pang, Junjie; Jiang, Yuchun; Han, Yongqin; Wang, Jianguo

doi:10.1016/j.electacta.2019.01.096

Cited by 10 publications

(4 citation statements)

References 38 publications

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“…32,33 In addition, the peak potential of the new peak was dependent on the proton donor (pK a of the acid). [32][33][34] As ATP (pK a2 6.95), 35 ADP (pK a2 6.88), 35 and CTP (pK a2 6.4) 36 were hydrolyzed to produce H 2 PO 4 − (pK a 7.…”

Section: Resultsmentioning

confidence: 99%

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Determination Method of the ATP, ADP, and CTP Concentrations by Electrochemical Reduction of Benzoquinone

Sun

Shao

et al. 2019

J. Electrochem. Soc.

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ATP, ADP, and cytidine triphosphate (CTP) are common sources of energy for various cellular activities. Therefore, a method that efficiently measures ATP, ADP, and CTP levels is urgently needed. In unbuffered solution, ATP, ADP, and CTP were observed to cause a new cathodic peak at a positive potential during benzoquinone (BQ) reduction. The hydrolysis of ATP, ADP, and CTP generated additional proton donors, which provided numerous protons for the reduction of BQ and formation of a large new cathodic peak. The peak current difference between the peaks caused by ATP, ADP, and CTP before and after hydrolysis was linear to the ATP, ADP, and CTP concentrations but independent of the BQ concentration. An electrochemical method for the detection of ATP, ADP, and CTP was developed using a bare glassy carbon electrode. The proposed method showed good selectivity for the detection of ATP samples.

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Section: Resultsmentioning

confidence: 99%

“…When the protons provided by ATP, ADP and CTP were depleted, the pH of the electrode surface increased abruptly, which caused the formation of the peaks A 2 , A 3 , B 2 , B 3 , C 2 , and C 3 . Wang 27,28,34 revealed that the peak current was dependent on the proton donor concentration.…”

Section: Resultsmentioning

confidence: 99%

Determination Method of the ATP, ADP, and CTP Concentrations by Electrochemical Reduction of Benzoquinone

Sun

Shao

et al. 2019

J. Electrochem. Soc.

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“…The correlation coefficient (R 2 ) is fairly good (R 2 = 0.993), favorable to attain an impressive LOD of 0.68 nM for PPi. The analytical efficiency of the coffee-Tryp-CuNCs-based fluorescence sensor is compared to the reported approaches [38][39][40][41][42][43][44][45][46][47][48][49][50][51] for detecting of OH and PPi, as shown in Tables 1 and 2.…”

Section: Sensitivity Of Coffee-tryp-cuncs Towards Oh and Ppimentioning

confidence: 99%

Microwave-assisted synthesis of green fluorescent copper nanoclusters: a novel approach for sensing of hydroxyl radicals and pyrophosphate ions via a “turn-off–on” mechanism

Harshita,

Park,

Kailasa

2023

New J. Chem.

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“…Therefore, measuring PPi levels is of great significance for the effective diagnosis of diseases. In recent years, the detection methods of PPi include liquid chromatography [11], ultraviolet-visible absorption spectrometry [12], capillary electrophoresis [13], and electrochemical analysis [14]. However, these methods may suffer from complex and time-consuming sample pretreatment, high cost, low sensitivity, and poor repeatability.…”

Section: Introductionmentioning

confidence: 99%

Ratiometric optical detection of pyrophosphate based on aggregation‐caused dual‐signal response of gold nanoclusters

et al. 2023

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Sensing of pyrophosphate ion (PPi) has received much attention due to the strong demand for clinical diagnostics. Here, based on gold nanoclusters (Au NCs), a ratiometric optical detection method for PPi is developed by simultaneously detecting the dual signals of fluorescence (FL) and second-order scattering (SOS). The PPi is detected by inhibiting the formation of aggregates of Fe 3+ with Au NCs. Binding of Fe 3+ to Au NCs causes aggregation of Au NCs, which leads to fluorescence quenching and scattering increasing. The presence of PPi can competitively bind Fe 3+ to redisperse the Au NCs and finally recover the fluorescence and reduce the scattering signal. The designed PPi sensor shows a high sensitivity with a linear range 5-50 μM and a detection limit of 1.2 μM. In addition, the assay has excellent selectivity for PPi, which makes its application in real biological samples extremely valuable.

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Electrochemical method of pyrophosphate determination by quinone reduction

Cited by 10 publications

References 38 publications

Determination Method of the ATP, ADP, and CTP Concentrations by Electrochemical Reduction of Benzoquinone

Determination Method of the ATP, ADP, and CTP Concentrations by Electrochemical Reduction of Benzoquinone

Microwave-assisted synthesis of green fluorescent copper nanoclusters: a novel approach for sensing of hydroxyl radicals and pyrophosphate ions via a “turn-off–on” mechanism

Ratiometric optical detection of pyrophosphate based on aggregation‐caused dual‐signal response of gold nanoclusters

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