Electrochemical lipolysis of subcutaneous adipose tissue in a porcine animal model

Abstract

Objectives There is a considerable demand for noninvasive low‐cost fat reduction methods with fewer side effects and shorter recovery times. This study aims to develop a fat‐reduction method through electrochemical lipolysis of subcutaneous adipocytes using needle‐based electrodes, body tissue fluids, and electrical current application. Methods Electrochemical lipolysis was performed by inserting a 4‐pin needle electrode connected to a DC power supply into the pig's abdomen. Applied electrical current (0.5 and 1 mA) and treatment time (5 or 10 minutes) were varied systematically. Ultrasound imaging was performed before and after treatment to determine changes in fat thickness. Tissue samples were collected at 0, 2, and 4 weeks posttreatment for histological evaluation to determine the mechanism of action and the procedure's efficacy. Results Electrochemical subcutaneous adipose tissue lipolysis in a porcine model was achieved through hydrolysis of physiologic fluid within the vicinity of the inserted electrode where an electric current is applied, leading to localized disruption of fat cell membranes and necrosis. Electric current configuration 1.0 mA showed more pronounced lipolysis effects applied for 10 minutes, significantly decreasing adipocyte content per treatment area. The electrochemical treatment method also stimulates collagen synthesis, which helps reduce fat. Conclusions Electrochemical lipolysis is a potential new noninvasive localized technique to reduce fat. The treatment method induces fat cell necrosis via in situ reduction‐oxidation reaction by the electrochemical activation of physiologic fluid in the surrounding tissue. Electrochemical lipolysis is a simple, low‐cost, fat‐reducing treatment method without harmful side effects.