Electrochemical Investigations on the NO-Releasing Property of Ruthenium Nitrosyl Complex

Abstract

In this study, the NO-donating property of [Ru(BPG)Cl(NO)]Cl (BPG = N,N-bis(2- pyridylmethyl)glycinato anion) via electrochemical activation was assessed. The synthesized BPG and [Ru(BPG)Cl(NO)]Cl were characterized by UV-Vis and FT-IR spectroscopy. To determine if NO may be released from the compound via one-electron reduction, cyclic voltammetric experiments in aqueous and non-aqueous solutions were performed using a three-electrode cell consisting of glassy carbon working electrode, Pt wire counter electrode and Ag/AgCl or Ag/Ag+ reference electrode. The [Ru(BPG)Cl(NO)]Cl complex showed two one-electron reversible reductions in dimethylformamide, which suggests decreased ability as NO donor. In aqueous solution at pH 2.0, [Ru(BPG)Cl(NO)]Cl exhibited a one-electron irreversible reduction, which could be assigned to a Ru-NO centered reduction. The irreversibility of the reduction could be due to NO labilization and suggests that [Ru(BPG)Cl(NO)]Cl could be a potential NO donor in acidic aqueous medium.