Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases

Bridge, Mary H.; Williams, Edna; Lyons, Michael E. G.; Tipton, Keith F.; Linert, Wolfgang

doi:10.1016/j.bbadis.2004.05.007

Cited by 44 publications

(34 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Traver et al [49] show in an experimental model of rat basal forebrain cholinergic neurons that noradrenaline might be neuroprotective, leading to a decreased concentration of reactive oxygen species produced by the Fenton reaction. This indicates that nicotine's effect on the Fenton reaction could be due to several mechanisms: local increase in catecholamines, inhibition of the autoxidation of 6-hydroxydopamine [28] , and by directly chelating free iron [27] .…”

Section: Discussionmentioning

confidence: 96%

“…This has led to further studies on nicotine -and it has been shown, in in vitro experiments, and in animal studies, to have anti-inflammatory and antiapoptotic abilities [20][21][22][23][24] . These effects of nicotine are mediated via nicotinergic acetylcholine receptors [25] , via direct binding to mitochondria [26] , and by direct effect on the Fenton reaction: in vitro studies have shown that nicotine is capable of chelating free iron [27,28] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Nicotine Infusion on Striatal Glutamate and Cortical Non-Protein-Bound Iron in Hypoxic Newborn Piglets

Andresen¹,

Saugstad

2008

Neonatology

View full text Add to dashboard Cite

Background: Perinatal asphyxia triggers a large cascade of mechanisms leading to brain damage. Release of glutamate and increased oxidative stress play substantial roles. Non-protein-bound iron (NPBI), which contributes to the production of free radical species through the Fenton reaction, increases in hypoxic-ischemic brain damage. Results from in vitro and adult animal studies show that nicotine can decrease extracellular levels of NPBI and glutamate. Nicotine’s effects have further been shown to be dose-dependent, with lower doses showing neuroprotective, and higher doses showing neurotoxic effects. Objectives: We wished to assess nicotine’s effect on levels of NPBI and glutamate in an animal model of neonatal hypoxic-ischemic brain damage. Methods: 47 anesthetized newborn piglets were randomized to one of four infusions after hypoxia (nicotine 130 µg/kg/h, 260 µg/kg/h, adrenaline 0.05 µg/kg/min, saline 2.6 ml/kg/h). Glutamate in striatum and NPBI in cortex were analyzed in microdialysate. Results: Striatal glutamate presented a significant rise for all the animals from baseline to the end of hypoxia (p < 0.001). There was a significant difference for nicotine 130 µg/kg/h versus saline (p = 0.002) 2 h after hypoxia. Cortical NPBI presented a significant rise from baseline to the end of hypoxia for all the animals (p < 0.001), and a significant difference between nicotine 130 µg/kg/h versus saline 2 h after hypoxia (p = 0.013). Conclusion: Our findings support the hypothesis that nicotine can decrease extracellular levels of glutamate and NPBI in a neonatal model of hypoxic-ischemic brain damage. This suggests possible neuroprotective effects of a low dose of nicotine in neonates, as it has already been shown in adult models.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Effects of Nicotine Infusion on Striatal Glutamate and Cortical Non-Protein-Bound Iron in Hypoxic Newborn Piglets

Andresen¹,

Saugstad

2008

Neonatology

View full text Add to dashboard Cite

show abstract

“…However, nicotine also has other beneficial effects on AD that are not mediated through the alpha7nAChRs. For instance, nicotine appears to protect the neuron cell against the Aβ42 toxicity by scavenging ROS and NO free radicals Liu and Zhao, 2004), chelating copper and iron (Bridge et al, 2004;Zhang et al, 2006) and protecting antioxidants in cells (Linert et al, 1999;Liu et al, 2003).…”

Section: Epidemiological Implications Of Nicotine In Neurodegenerativmentioning

confidence: 99%

Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration

Conejero-Goldberg

Davies

Ulloa

2008

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people worldwide. Classical studies focused on the description and characterization of the pathological hallmarks found in AD patients including the neurofibrillary tangles and the amyloid plaques. Current strategies focus on the etiology of these hallmarks and the different mechanisms contributing to neurodegeneration. Among them, recent studies reveal the close interplay between the immunological and the neurodegenerative processes. This article examines the implications of the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) as a critical link between inflammation and neurodegeneration in AD. Alpha7nAChRs are not only expressed in neurons but also in Glia cells where they can modulate the immunological responses contributing to AD. Successful therapeutic strategies against AD should consider the connections between inflammation and neurodegeneration. Among them, alpha7nAChR may represent a pharmacological target to control these two mechanisms during the pathogenesis of neurodegenerative and behavioral disorders.

show abstract

“…Nicotine has been shown to act on nicotinergic acetylcholine receptors (nAChRs) and mitochondria [7,26] , it inhibits the Fenton reaction [27] , and it has a direct effect on neurotrophic factors in the CNS [28] . These mechanisms are thus more likely to be responsible for the positive effects of nicotine.…”

Section: Discussionmentioning

confidence: 99%

Nicotine in a Small-to-Moderate Dose Does Not Cause a Significant Increase in Plasma Catecholamine Levels in Newborn Piglets

Andresen¹,

Godang

Munkeby³

et al. 2008

Neonatology

View full text Add to dashboard Cite

Background: Nicotine has a wide range of effects. Several studies are being undertaken investigating the positive effects on inflammation and apoptosis. Recently, nicotine has been investigated in a piglet model of perinatal asphyxia, where the question has been raised whether nicotine’s effect on the sympathetic nervous system can explain some of the positive effects. Objectives: We hypothesized that nicotine in small-to-moderate doses would not cause a significant increase in plasma catecholamine levels, whereas a higher dose would give a significant effect, confirming the believed dose-dependent matter in which nicotine exerts its effect on the sympathetic nervous system. Methods: Seventeen anesthetized newborn piglets were randomized to one of three doses of nicotine (130, 260 or 1,000 µg/kg/h) that was given intravenously for 1 h. Blood samples for catecholamine analyzes were drawn at baseline and at the end of the infusion. Catecholamines were determined using HPLC. Results: No significant increase in catecholamines was detected in the animals treated with the small or moderate nicotine doses, whereas the higher dose gave a significant increase in adrenaline (p = 0.019). Conclusion: Nicotine in small-to-moderate doses does not cause significant increase in plasma catecholamines, thus indicating that the positive effects of nicotine in studies using these doses most likely cannot be explained by the systemic release of catecholamines.

show abstract

Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases

Cited by 44 publications

References 26 publications

Effects of Nicotine Infusion on Striatal Glutamate and Cortical Non-Protein-Bound Iron in Hypoxic Newborn Piglets

Effects of Nicotine Infusion on Striatal Glutamate and Cortical Non-Protein-Bound Iron in Hypoxic Newborn Piglets

Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration

Nicotine in a Small-to-Moderate Dose Does Not Cause a Significant Increase in Plasma Catecholamine Levels in Newborn Piglets

Contact Info

Product

Resources

About