Electrochemical impedance spectroscopy biosensor with interdigitated electrode for detection of human immunoglobulin A

Ohno, Ryuzo; Ohnuki, Hitoshi; Wang, Huihui; Yokoyama, Takuya; Endo, Hideki; Tsuya, Daiju; Izumi, Mitsuru

doi:10.1016/j.bios.2012.07.052

Cited by 116 publications

(67 citation statements)

References 15 publications

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“…suggested that, for an IgA biosensor device, the organic layer‐modified electrode surface was actually divided into two parts: an interfacial part (expressed as a parallel connection of R CT and C DL ) and an inner part (expressed as constant R and CPE). After binding of the IgA sample to the anti‐IgA layer, only R CT increased, and LOD of 0.01 ng mL −1 could be achieved …”

Section: Circuit Modelling Data Interpretation and Validationmentioning

confidence: 99%

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

et al. 2018

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affinity biosensors are, without any doubt, among the most sensitive analytical devices available, offering low limits of detection and wide linear response ranges. There are, however, only a few papers detailing the application of impedimetric biosensors for the analysis of clinically relevant samples with due clinical performance. The fact that these devices have not found their way to any commercial or clinical use to date might be surprising, since an electrochemical assay platform based on portable potentiostats is a success story for monitoring a range of clinical parameters such as ions, haematological indicators and glucose. This review discusses the reasons behind this discrepancy and addresses the barriers to be overcome in order to achieve the point-of-care diagnostics using such devices for detection of protein oncomarkers approved by FDA. The final part of the review covers the most recent progress in the area.[a] Dr.

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Section: Circuit Modelling Data Interpretation and Validationmentioning

confidence: 99%

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

et al. 2018

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“…Lee et al [115] had developed an aptasensor targeting pLDH, the schematic of which is shown in Figure 3. Electrochemical impedance spectroscopy was the detection platform because of its sensitivity [168] and label-free attributes [169]. The detection limit reported with the sensor was 108.5 fM and 120.1 fM for PvLDH and PfLDH, respectively [115].…”

Section: Detection Of Malariamentioning

confidence: 99%

Potential Biomarkers and Their Applications for Rapid and Reliable Detection of Malaria

Jain

Chakma

Patra

et al. 2014

BioMed Research International

107

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Malaria has been responsible for the highest mortality in most malaria endemic countries. Even after decades of malaria control campaigns, it still persists as a disease of high mortality due to improper diagnosis and rapidly evolving drug resistant malarial parasites. For efficient and economical malaria management, WHO recommends that all malaria suspected patients should receive proper diagnosis before administering drugs. It is thus imperative to develop fast, economical, and accurate techniques for diagnosis of malaria. In this regard an in-depth knowledge on malaria biomarkers is important to identify an appropriate biorecognition element and utilize it prudently to develop a reliable detection technique for diagnosis of the disease. Among the various biomarkers, plasmodial lactate dehydrogenase and histidine-rich protein II (HRP II) have received increasing attention for developing rapid and reliable detection techniques for malaria. The widely used rapid detection tests (RDTs) for malaria succumb to many drawbacks which promotes exploration of more efficient economical detection techniques. This paper provides an overview on the current status of malaria biomarkers, along with their potential utilization for developing different malaria diagnostic techniques and advanced biosensors.

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“…On increasing the N, D and W for μ-IDEs it results in an increase in overall output signal due to increased surface area of μ-IDEs [15]. When a medium (GO, in present case) is placed between the μ-IDEs and potential is applied to the electrode, an electric field is set up in Al-ȝ-IDEs [14]. On addition of the sensing solution (aqueous F -) to GOAl-ȝ-IDEs, change in the dielectric constant, capacitance, conductance, impedance of μ-IDEs was observed.…”

Section: Ide Working Principle and Advantagesmentioning

confidence: 99%

“…IDEs based MEMS are potential candidate for surface acoustic wave (SAW), rapid biomedical and electrochemical sensors, owing to its several advantages [13,14]. IDEs consist of two identical, parallel spaced array of electrode like a comb type structure to form an interdigitated system.…”

Section: Ide Working Principle and Advantagesmentioning

confidence: 99%

GO/μ -- IDEs/p-Si Based Real Time Sensors for F-Detection in Natural Drinking Water

Soni

Arora

Kumar

et al. 2015

2015 IEEE International Symposium on Nanoelectronic and Information Systems

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Molecular interaction between Graphene oxide (GO) synthesized using chemical oxidation of graphite and lithography patterned aluminum (Al) micro-interdigitated electrodes (ȝ-IDEs) on p-Si for aqueous fluoride ion (F -) sensor is demonstrated. The strong hydrogen bonding and molecular adsorption of aqueous F -onto the active hydrophilic sites (hydroxyl, carbonyl, carboxyl, epoxy) present in GO integrated with Al-ȝ-IDEs is examined using electrical characterization (current-voltage, capacitance-frequency). The current for GOAl-ȝ-IDEs shows almost 2.3, 4.7 times increase for F -solution of 0.1 and 1 ppm with respect to GO. Additionally, the integration of GO-Al-ȝ-IDEs shows almost three order increase in the current for F -solution of 10 ppm. The adsorption of F -onto the GO film results the increase in charge carriers and finally results the increase in the output current response. Owing to the saturation in the binding sites present onto GO for F -solution of 100 ppm, the F -penetrate the GO film and results the decrease in current of the sensor. Thus, the cost effective, easy processability and selectivity of proposed GO-integrated Al-ȝ-IDE based real time sensors have a great potential to be a forefront sensor for detection of aqueous F -present in natural drinking water.

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Electrochemical impedance spectroscopy biosensor with interdigitated electrode for detection of human immunoglobulin A

Cited by 116 publications

References 15 publications

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Potential Biomarkers and Their Applications for Rapid and Reliable Detection of Malaria

GO/μ -- IDEs/p-Si Based Real Time Sensors for F-Detection in Natural Drinking Water

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Electrochemical impedance spectroscopy biosensor with interdigitated electrode for detection of human immunoglobulin A

Cited by 116 publications

References 15 publications

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

Potential Biomarkers and Their Applications for Rapid and Reliable Detection of Malaria

GO/&#x03BC; -- IDEs/p-Si Based Real Time Sensors for F-Detection in Natural Drinking Water

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Product

Resources

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GO/μ -- IDEs/p-Si Based Real Time Sensors for F-Detection in Natural Drinking Water