Electrochemical impedance spectroscopy analysis of A-beta (1-42) peptide using a nanostructured biochip

Wu, Chenhao; Ku, Bien-Chen; Ko, Chien-Hsien; Chiu, Chun-Che; Wang, Gou‐Jen; Yang, Yuan‐Han; Wu, Shyh-Jong

doi:10.1016/j.electacta.2014.04.132

Cited by 45 publications

(17 citation statements)

References 43 publications

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“…Recently, there have also been some attempts for detecting Aβ species, probing its aggregation and investigating its interaction with biomolecules, drugs as well as metal ions by electrochemical techniques [16][17][18][19][20][21][22][23][24][25]. Typically, Vestergaard and co-workers presented the kinetic study of Aβ aggregation by monitoring the electrochemical oxidation of tyrosine residue in Aβ [16].…”

Section: Introductionmentioning

confidence: 98%

Electrochemical detection of amyloid-β oligomer with the signal amplification of alkaline phosphatase plus electrochemical–chemical–chemical redox cycling

Liu

Xia

Jiang

et al. 2015

Journal of Electroanalytical Chemistry

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Section: Introductionmentioning

confidence: 98%

Electrochemical detection of amyloid-β oligomer with the signal amplification of alkaline phosphatase plus electrochemical–chemical–chemical redox cycling

Liu

Xia

Jiang

et al. 2015

Journal of Electroanalytical Chemistry

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“…Scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to verify the three-dimensional surface morphologies of the biosensor after the binding of the Ab 42 and other consecutive layers. As result, they obtained a biosensor with a linear detection range between 1 and 10 ng mL -1 [20]. …”

Section: Electrochemical Impedance Spectroscopymentioning

confidence: 99%

β-Amyloid Biomarker Detection for Alzheimer’s Disease

Grajales

Shuang

et al. 2017

J. Anal. Test.

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Alzheimer's disease (AD) is a neurodegenerative disease. It is a type of dementia and it mainly deals with thinking, memory and behavioral aspects. It is a progressive disease, which in course of time damages most sections of the brain. Beta amyloid peptides (Ab) have been recognized as potential biomarkers to monitor AD. The Ab protein is made up of 39-42 amino acids, which are the main components of the plaques found in the AD brain. This beta amyloid is toxic to the neurons and causes degeneration. In order to measure these biomarkers, nanobiosensing techniques are used. Timely monitoring of Ab levels helps in the detection of the irreversible disease called AD. These techniques fall in two categories, viz., in vitro and in vivo. Several techniques like electrochemical techniques, cantilever-based liposome biosensor, ELISA, PET scan, microdialysis, etc., are discussed further in the article. These techniques can prove to be effective methods for quantifying amyloid deposition within specific brain regions.

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“…For instance, Wu et al [6] showed that a biosensor to detect the A-beta (1-42) peptide in predicting Alzheimer disease could be fabricated in which SAM (11-mercaptoundecanoic acid) modified gold coated AAO was used as sensing platform. In this configuration, before SAM was done, a thin gold film was sputtered onto the AAO substrate to serve as an electrode for metal deposition.…”

Section: Self Assembly Monolayersmentioning

confidence: 99%

Soft and Hard Surface Manipulation of Nanoporous Anodic Aluminum Oxide (AAO)

et al. 2015

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Nanoporous materials with straight channels have attracted considerable interest due to their unique physical properties and many potential applications such as separation, sensing, biomedical and electronics. For the last few decades, nanoporous alumina or anodic aluminium oxide (AAO) membrane is gaining attention due to its broad applicability in various applications. The unique properties of AAO membrane coupled with tunable surface modification and properties is playing an increasingly important platform in a diverse range of applications such as separation, energy storage, drug delivery and template synthesis, as well as biosensing, tissue engineering and catalytic studies. This chapter aims to introduce the recent advances and challenges for surface manipulation of AAO following the 'soft' and 'hard' modification strategies. The functions of these modified nanostructures materials and latest important applications are evaluated with respect to improved performance and possible implications of those strategies for the future trends of surface engineering are discussed.

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Electrochemical impedance spectroscopy analysis of A-beta (1-42) peptide using a nanostructured biochip

Cited by 45 publications

References 43 publications

Electrochemical detection of amyloid-β oligomer with the signal amplification of alkaline phosphatase plus electrochemical–chemical–chemical redox cycling

Electrochemical detection of amyloid-β oligomer with the signal amplification of alkaline phosphatase plus electrochemical–chemical–chemical redox cycling

β-Amyloid Biomarker Detection for Alzheimer’s Disease

Soft and Hard Surface Manipulation of Nanoporous Anodic Aluminum Oxide (AAO)

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