Electrochemical Immunosensors

Harshavardhan, Shakila; Rajadas, Sam Ebenezer; Vijayakumar, Kevin Kumar; Durai, Willsingh Anbu; Ramu, A.; Rajan, Mariappan

doi:10.1002/9781119611103.ch18

Cited by 9 publications

(2 citation statements)

References 157 publications

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“…Surface or antibody modification potentially leads to biomolecule activity loss. Several immunosensors have emerged, whereby biochemical, physical or enzymatic interactions have been employed to fulfill their specific function [ 163 ]. The resulting immunocomplex generates signals commonly detected through sandwiched or direct assays.…”

Section: Paper-based Eismentioning

confidence: 99%

Advances in paper-based electrochemical immunosensors: review of fabrication strategies and biomedical applications

du Plooy,

Jahed,

Iwuoha

et al. 2023

R. Soc. open sci.

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Cellulose paper-based sensing devices have shown promise in addressing the accuracy, sensitivity, selectivity, analysis time and cost of current disease diagnostic tools owing to their excellent physical and physiochemical properties, high surface-area-to-volume ratio, strong adsorption capabilities, ease of chemical functionalization for immobilization, biodegradability, biocompatibility and liquid transport by simple capillary action. This review provides a comprehensive overview of recent advancements in the field of electrochemical immunosensing for various diseases, particularly in underdeveloped regions and globally. It highlights the significant progress in fabrication techniques, fluid control, signal transduction and paper substrates, shedding light on their respective advantages and disadvantages. The primary objective of this review article is to compile recent advances in the field of electrochemical immunosensing for the early detection of diseases prevalent in underdeveloped regions and globally, including cancer biomarkers, bacteria, proteins and viruses. Herein, the critical need for new, simplistic early detection strategies to combat future disease outbreaks and prevent global pandemics is addressed. Moreover, recent advancements in fabrication techniques, including lithography, printing and electrodeposition as well as device orientation, substrate type and electrode modification, have highlighted their potential for enhancing sensitivity and accuracy.

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Section: Paper-based Eismentioning

confidence: 99%

Advances in paper-based electrochemical immunosensors: review of fabrication strategies and biomedical applications

du Plooy,

Jahed,

Iwuoha

et al. 2023

R. Soc. open sci.

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“…Immunoassay methods are developed based on antibody–antigen reactions. Mycotoxins are small non-immunogenic molecules [ 35 ]. The designing of specific antibodies against mycotoxins (analyte) and hapten is a crucial step for immunoassays.…”

Section: Advance Multi-mycotoxin Immuno-based Analysismentioning

confidence: 99%

Recent advances in immunoassay-based mycotoxin analysis and toxicogenomic technologies

Liew¹,

Sabran²

2022

Journal of Food and Drug Analysis

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The co-occurrence and accumulation of mycotoxin in food and feed constitutes a major issue to food safety, food security, and public health. Accurate and sensitive mycotoxins analysis can avoid toxin contamination as well as reduce food wastage caused by false positive results. This mini review focuses on the recent advance in detection methods for multiple mycotoxins, which mainly depends on immunoassay technologies. Advance immunoassay technologies integrated in mycotoxin analysis enable simultaneous detection of multiple mycotoxins and enhance the outcomes’ quality. It highlights toxicogenomic as novel approach for hazard assessment by utilizing computational methods to map molecular events and biological processes. Indeed, toxicogenomic is a powerful tool to understand health effects from mycotoxin exposure as it offers insight on the mechanisms by which mycotoxins exposures cause diseases.

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