Electrochemical immunosensor based on titanium dioxide grafted MXene for EpCAM antigen detection

Sweety,; Kumar, Devendra

doi:10.1016/j.jcis.2023.08.099

Cited by 10 publications

(1 citation statement)

References 49 publications

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“…In addition, to ensure sufficient sensitivity of electrochemical immunosensors, many efforts have been made to improve the electrochemical response towards the electrochemical probe by modifying various nanomaterials on the electrodes, such as carbon nanomaterials [ 17 ], metal and nonmetallic nano-oxides [ 18 , 19 ] and noble metal nanoparticles [ 20 ]. Amongst them, metal sulfides display great potential for signal amplification, due to their properties of good catalytic activity and good biocompatibility [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Label-Free Electrochemical Immunosensor for the Detection of Thyroid Transcription Factor 1 Using Ribbon-like Tungsten Disulfide-Reduced Graphene Oxide Nanohybrids and Gold Nanoparticles

Wang,

Tang,

Zhou

et al. 2024

Molecules

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Thyroid transcription factor 1 (TTF1) is an important cancer-related biomarker for clinical diagnosis, especially for carcinomas of lung and thyroid origin. Herein, a novel label-free electrochemical immunosensor was prepared for TTF1 detection based on nanohybrids of ribbon-like tungsten disulfide-reduced graphene oxide (WS2-rGO) and gold nanoparticles (AuNPs). The proposed immunosensor employed H2O2 as the electrochemical probe because of the excellent peroxidase-like activity of ribbon-like WS2-rGO. The introduction of AuNPs not only enhanced the electrocatalytic activity of the immunosensor, but also provided immobilization sites for binding TTF1 antibodies. The electrochemical signals can be greatly amplified due to their excellent electrochemical performance, which realized the sensitive determination of TTF1 with a wide linear range of 0.025–50 ng mL−1 and a lower detection limit of 0.016 ng mL−1 (S/N = 3). Moreover, the immunosensor exhibited high selectivity, good reproducibility, and robust stability, as well as the ability to detect TTF1 in human serum with satisfactory results. These observed properties of the immunosensor enhance its potential practicability in clinical applications. This method can also be used for the detection of other tumor biomarkers by using the corresponding antigen–antibody complex.

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Section: Introductionmentioning

confidence: 99%

A Novel Label-Free Electrochemical Immunosensor for the Detection of Thyroid Transcription Factor 1 Using Ribbon-like Tungsten Disulfide-Reduced Graphene Oxide Nanohybrids and Gold Nanoparticles

Wang,

Tang,

Zhou

et al. 2024

Molecules

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Development of Ti₃C₂T_x‐based novel immunosensor for cancer biomarker detection

Sweety,

Kumar

2024

Applied Organom Chemis

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In this study, an ultrasensitive label‐free electrochemical immunosensor based on Ti3C2Tx (Mxene) with a 2D‐layered morphology has been proposed for the detection of EpCAM antigen. A hydrothermal method is employed for the synthesis of Ti3C2Tx by using a less toxic exfoliating reagent, NaBF4. The bioelectrode, BSA/anti‐EpCAM/Ti3C2Tx@ITO, has been fabricated by electrophoretic deposition of Ti3C2Tx onto the ITO electrode, followed by an immobilization of EpCAM antibody. Electrochemical response studies reveal that the immunosensor shows a high sensitivity of 29.22 μA fg−1 ml cm−2 and a wide linear range from 0.1 fg/ml to 100 ng/ml, for EpCAM antigen detection. Further, the good stability of this fabricated immunosensor is an additional advantage for EpCAM antigen detection in serum samples.

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Nucleic acid aptasensor with magnetically induced self-assembly for the detection of EpCAM glycoprotein

Yue,

Ouyang,

et al. 2023

Microchim Acta

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Electrochemical immunosensor based on titanium dioxide grafted MXene for EpCAM antigen detection

Cited by 10 publications

References 49 publications

A Novel Label-Free Electrochemical Immunosensor for the Detection of Thyroid Transcription Factor 1 Using Ribbon-like Tungsten Disulfide-Reduced Graphene Oxide Nanohybrids and Gold Nanoparticles

A Novel Label-Free Electrochemical Immunosensor for the Detection of Thyroid Transcription Factor 1 Using Ribbon-like Tungsten Disulfide-Reduced Graphene Oxide Nanohybrids and Gold Nanoparticles

Development of Ti₃C₂T_x‐based novel immunosensor for cancer biomarker detection

Nucleic acid aptasensor with magnetically induced self-assembly for the detection of EpCAM glycoprotein

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Electrochemical immunosensor based on titanium dioxide grafted MXene for EpCAM antigen detection

Cited by 10 publications

References 49 publications

A Novel Label-Free Electrochemical Immunosensor for the Detection of Thyroid Transcription Factor 1 Using Ribbon-like Tungsten Disulfide-Reduced Graphene Oxide Nanohybrids and Gold Nanoparticles

A Novel Label-Free Electrochemical Immunosensor for the Detection of Thyroid Transcription Factor 1 Using Ribbon-like Tungsten Disulfide-Reduced Graphene Oxide Nanohybrids and Gold Nanoparticles

Development of Ti3C2Tx‐based novel immunosensor for cancer biomarker detection

Nucleic acid aptasensor with magnetically induced self-assembly for the detection of EpCAM glycoprotein

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Product

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Development of Ti₃C₂T_x‐based novel immunosensor for cancer biomarker detection