Electrochemical Evaluation of Some Mg-Ca-Mn-Zr Biodegradable Alloys

Istrate, Bogdan; Munteanu, Corneliu; Chelariu, R.; Dumitru, Mihai; Cimpoeșu, Ramona; Tudose, Florin Sandu Ville

doi:10.37358/rc.19.9.7565

Rev. Chim.

2019

DOI: 10.37358/rc.19.9.7565

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Electrochemical Evaluation of Some Mg-Ca-Mn-Zr Biodegradable Alloys

Bogdan Istrate¹,

Corneliu Munteanu²,

R. Chelariu³

et al.

Abstract: Biodegradable magnesium alloys represent a class of materials with high properties that are used in a wide range of fields, such as medicine, aeronautics and automotive. Alloying the Mg-based alloys with small percentages of elements such as Ca, Mn and Zr can conduct to the obtaining of some materials that can be the basis for the development of orthopedic implants. Calcium contributes to the formation of the Mg2Ca lamellar compound, low concentrations of zirconium helps the microstructure refinement and corro… Show more

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Cited by 2 publications

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Assessment of the Effects of Si Addition to a New TiMoZrTa System

et al. 2021

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Ti-based alloys are widely used in medical applications. When implant devices are used to reconstruct disordered bone, prevent bone resorption and enhance good bone remodeling, the Young’s modulus of implants should be close to that of the bone. To satisfy this requirement, many titanium alloys with different biocompatible elements (Zr, Ta, Mo, Si etc.) interact well with adjacent bone tissues, promoting an adequate osseointegration. Four new different alloys were obtained and investigated regarding their microstructure, mechanical, chemical and biological behavior (in vitro and in vivo evaluation), as follows: Ti20Mo7Zr15Ta, Ti20Mo7Zr15Ta0.5Si, Ti20Mo7Zr15Ta0.75Si and Ti20Mo7Zr15TaSi. 60 days after implantation, both in control and experimental rabbits, at the level of implantation gap and into the periimplant area were found the mesenchymal stem cells which differentiate into osteoblasts, then osteocytes and osteoclasts which are involved in the new bone synthesis and remodeling, the periimplant fibrous capsule being continued by newly spongy bone tissue, showing a good osseointegration of alloys. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay confirmed the in vitro cytocompatibility of the prepared alloys.

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Assessment of the Effects of Si Addition to a New TiMoZrTa System

et al. 2021

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Influence of the Phase Composition of Titanium Alloys on Cell Adhesion and Surface Colonization

Straumal,

Anisimova,

Kiselevskiy

et al. 2023

Materials

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The pivotal role of metal implants within the host’s body following reconstructive surgery hinges primarily on the initial phase of the process: the adhesion of host cells to the implant’s surface and the subsequent colonization by these cells. Notably, titanium alloys represent a significant class of materials used for crafting metal implants. This study, however, marks the first investigation into how the phase composition of titanium alloys, encompassing the volume fractions of the α, β, and ω phases, influences cell adhesion to the implant’s surface. Moreover, the research delves into the examination of induced hemolysis and cytotoxicity. To manipulate the phase composition of titanium alloys, various parameters were altered, including the chemical composition of titanium alloys with iron and niobium, annealing temperature, and high-pressure torsion parameters. By systematically adjusting these experimental parameters, we were able to discern the distinct impact of phase composition. As a result, the study unveiled that the colonization of the surfaces of the examined Ti–Nb and Ti–Fe alloys by human multipotent mesenchymal stromal cells exhibits an upward trend with the increasing proportion of the ω phase, concurrently accompanied by a decrease in the α and β phases. These findings signify a new avenue for advancing Ti-based alloys for both permanent implants and temporary fixtures, capitalizing on the ability to regulate the volume fractions of the α, β, and ω phases. Furthermore, the promising characteristics of the ω phase suggest the potential emergence of a third generation of biocompatible Ti alloys, the ω-based materials, following the first-generation α-Ti alloys and second-generation β alloys.

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Electrochemical Evaluation of Some Mg-Ca-Mn-Zr Biodegradable Alloys

Cited by 2 publications

References 11 publications

Assessment of the Effects of Si Addition to a New TiMoZrTa System

Assessment of the Effects of Si Addition to a New TiMoZrTa System

Influence of the Phase Composition of Titanium Alloys on Cell Adhesion and Surface Colonization

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