Electrochemical DNA Biosensors Based on the Intrinsic Topological Insulator BiSbTeSe₂ for Potential Application in HIV Determination

Abstract

In this work, we reported a sensitive, label-free electrochemical biosensor based on the intrinsic topological insulator (TI) BiSbTeSe2 for potential application in the determination of the HIV gene. With strong spin–obit coupling, TIs could have robust surface states with low electronic noise, which might be beneficial for the stable and sensitive electron transport between the electrode and electrolyte interface. Under optimized conditions of the biosensors using BiSbTeSe2, the differential pulse voltammetry (DPV) peak currents showed a linear relationship with the logarithm of target DNA concentrations ranging from 1.0 × 10–13 to 1.0 × 10–7 M, with a detection limit of 1.07 × 10–15 M. The sensing assay also displayed good selectivity and stability after storage at 4 °C for 7 days. This work provides an effective way to develop biosensors with topological materials, which have a potential application in the clinical determination and monitoring field.

Femtosecond Fiber Laser Based on BiSbTeSe2 Quaternary Material Saturable Absorber

“…As a novel quaternary TI material, the BiSbTeSe2 has obtained some interesting results in recent years due to its strong spin-orbit coupling effect and stable energy gap. [45][46][47] Some studies have shown that the band gap of the BiSbTeSe2 is 0.25 eV, [48] and the carrier density can reach 10 12 cm −2 . [49] At the same time, German et al have shown that the BiSbTeSe2 is one of the most bulkinsulating three-dimensional TIs, [50] which makes it important in the TI research.…”

Defect identification of electricity transmission line insulators based on the improved lightweight network model with computer vision assistance

“…This research was of great significance for the reliability and security of power systems and provided valuable research and application references for related fields [ 15 ]. Jiang et al (2022) opted for optimized texture features to project insulator images and searched for insulator position information through the projected images [ 16 ]. Liu et al (2021) applied the Harris corner detection algorithm to both the target image and the template image, matching feature information with template feature information.…”

Development of nanobiosensors for human immunodeficiency virus detection—a mini review

“…It is an electrochemical biosensor, where the peak of the DPV current varies for single-stranded DNA (ssDNA) and dsDNA. Using the intrinsic topological insulator (TI) BiSbTeSe 2 , Jiang et al [40], have developed a very sensitive, label-free electrochemical biosensor that can be used to determine HIV gene expression. In addition to having stable and sensitive electron transport, TIs with strong spin-orbit coupling may have robust surface states with low electronic noise.…”

“…DPV peak currents performed well after storage at 4°C for 7 days, and the biosensors had good selectivity and stability. Using topological materials, this study provides an effective method of developing biosensors that can be used for the determination of clinical markers and monitoring [40]. In another similar study by Xiong et al [41], a large-size Bi 2 Se 3 tape electrode (BTE) was prepared using a single crystal of 2 cm × 1 cm × 0.5 cm.…”