Electrochemical determination of some antidiabetic drugs for type 2 diabetic patients

Badawy, W. A.; El-Ries, M. A.; Mahdi, Inas M.

doi:10.1016/j.talanta.2010.04.006

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…As reported in the literature, several papers have been published for the electrochemical detection of glimepiride (GLI) using various kinds of working electrode ( Table 6 ). The vast majority of GLI voltametric sensors are based on the utilization of carbon-based electrodes, including carbon paste electrodes and glassy carbon electrodes [ 67 , 68 , 69 ], as well as hanging drop mercury electrodes [ 70 , 71 , 72 , 73 ]. These papers have focused on understanding the electrochemical behavior of GLI at a particular sensor and its quantitative determination, either alone or in combination with other antidiabetic drugs.…”

Section: Electrochemical Measurements Of Antidiabetic Drugsmentioning

confidence: 99%

Electrochemical Assays for the Determination of Antidiabetic Drugs—A Review

Fendrych,

Górska-Ratusznik,

Smajdor

2023

Micromachines

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This article presents the current state of knowledge regarding electrochemical methods for determining the active substances within drugs that are used in the treatment of type 1 and type 2 diabetes. Electrochemical methods of analysis, due to their sensitivity and easiness, are a great alternative to other, usually more expensive analytical assays. The determination of active substances mentioned in this review is based on oxidation or reduction processes on the surface of the working electrode. A wide variety of working electrodes, often modified with materials such as nanoparticles or conducting polymers, have been used for the highly sensitive analysis of antidiabetic drugs. The presented assays allow us to determine the compounds of interest in various samples, such as pharmaceutical products or different human bodily fluids.

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Section: Electrochemical Measurements Of Antidiabetic Drugsmentioning

confidence: 99%

Electrochemical Assays for the Determination of Antidiabetic Drugs—A Review

Fendrych,

Górska-Ratusznik,

Smajdor

2023

Micromachines

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“…Fahim et al (2014) described a transmission Fourier transform infrared spectroscopy (FTIR) technique for analysis of metformin and glimepiride in drug samples. Badawy et al (2010) performed quantitative measurement of glimepiride, and three other anti-diabetic drugs, rosiglitazone, pioglitazone and glyburide, using cyclic voltammetry and differential pulse voltammetry. Several research groups developed and validated analytical methods based on high performance liquid chromatographic (HPLC) and high performance thin layer liquid chromatography (HPTLC) for the determination of glimepiride individually or with some other anti-diabetic drugs (Jain et al, 2008, Kovaříková et al, 2004, Ni et al, 2014, Dash et al, 2016, Sane et al, 2004a, Sane et al, 2004b, Shaodong et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A rapid hydrophilic interaction liquid chromatographic determination of glimepiride in pharmaceutical formulations

Zhou

Zuo

et al. 2017

Saudi Pharmaceutical Journal

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Glimepiride is one of the most widely prescribed antidiabetic drugs and contains both hydrophobic and hydrophilic functional groups in its molecules, and thus could be analyzed by either reversed-phase high performance liquid chromatography (HPLC) or hydrophilic interaction liquid chromatography (HILIC). In the literature, however, only reversed-phase HPLC has been reported. In this study, a simple, rapid and accurate hydrophilic interaction liquid chromatographic method was developed for the determination of glimepiride in pharmaceutical formulations. The analytical method comprised a fast ultrasound-assisted extraction with acetonitrile as a solvent followed by HILIC separation and quantification using a Waters Spherisorb SNH hydrophilic column with a mobile phase consisting of acetonitrile and aqueous acetate buffer (5.0 mM). The retention time of glimepiride increased slightly with decrease of mobile phase pH value from 6.8 to 5.8 and of acetonitrile content from 60% to 40%, indicating that both hydrophilic, ionic, and hydrophobic interactions were involved in the HILIC retention and elution mechanisms. Quantitation was carried out with a mobile phase of 40% acetonitrile and 60% aqueous acetate buffer (5.0 mM) at pH 6.3, by relating the peak area of glimepiride to that of the internal standard, with a detection limit of 15.0 μg/L. UV light absorption responses at 228 nm were linear over a wide concentration range from 50.0 μg/L to 6.00 mg/L. The recoveries of the standard added to pharmaceutical tablet samples were 99.4-103.0% for glimepiride, and the relative standard deviation for the analyte was less than 1.0%. This method has been successfully applied to determine the glimepiride contents in pharmaceutical formulations.

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“…It is used for the treatment of type II diabetes mellitus either alone or in combination with other oral antidiabetic drugs. Various methods reported for the assay of pioglitazone alone or its combination with other drugs is HPLC [9][10][11][12], HPTLC [13], spectrophotometry [14,15], LCMS/MS [16], chemometrics [17] and voltametry [18].…”

Section: Introductionmentioning

confidence: 99%

Method Development and Validation of Metformine, Pioglitazone and Glibenclamide in Tablet Dosage Form by using RP-HPLC

Tengli¹

2013

Biochem Anal Biochem

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Reverse phase high performance liquid chromatographic method has developed for the simultaneous estimation of metformine, pioglitazone and glibenclamide in tablet dosage for using gliclazide as an internal standard. The separation was achieved at ambient temperature with low pressure gradient mode by using 5 µ size phenomenex luna CN (100R 250×4.60 (mm) column with mobile phase containing acetonitrile, water and buffer (0.5% potassium dihydrogen phosphate) pH 2.5 adjusted with orthophosphoic acid in the ratio of 60:20:20. The flow rate was 1 mL min -1 and eluent was monitored at 230 nm by using UV detector. The selected chromatographic conditions effectively separated Metformine, pioglitazone and Glibenclamide with the retention time of 2.2, 2.8 and 5.8 min respectively. The linearity range for metformine, pioglitazone and glibenclamide is found in the range of 50-300 µg mL -1 , 1.5-9.0 µg mL -1 and 0.5-3.0 µg mL -1 respectively. The developed method was found to be accurate, simple, specific and reproducible. It can also be used for routine quality control analysis of these antidiabetic drugs in combinational dosage forms.

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Electrochemical determination of some antidiabetic drugs for type 2 diabetic patients

Cited by 8 publications

References 14 publications

Electrochemical Assays for the Determination of Antidiabetic Drugs—A Review

Electrochemical Assays for the Determination of Antidiabetic Drugs—A Review

A rapid hydrophilic interaction liquid chromatographic determination of glimepiride in pharmaceutical formulations

Method Development and Validation of Metformine, Pioglitazone and Glibenclamide in Tablet Dosage Form by using RP-HPLC

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