Electrochemical detection of serotonin: A new approach

Khoshnevisan, Kamyar; Honarvarfard, Elham; Torabi, Farzad; Maleki, Hassan; Baharifar, Hadi; Faridbod, Farnoush; Larijani, Bagher; Khorramizadeh, Mohammad Reza

doi:10.1016/j.cca.2019.10.028

Cited by 60 publications

(24 citation statements)

References 77 publications

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“…These findings suggest that cluster Networking Research authorship of EMRI, researchers who are involved in promoting global science shows [34,35]. In these clusters, there are authors of various specialties that demonstrate the dynamics of research in the EMRI and, on the other hand, can have a significant impact on the further development of the scientific field [7,8,13,29].…”

Section: Discussionmentioning

confidence: 99%

Visualization of knowledge flow in interpersonal scientific collaboration network endocrinology and metabolism research institute

Shahmoradi

Ramezani

Atlasi

et al. 2020

J Diabetes Metab Disord

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Purpose Research collaborations can help to increase scientific productivity. The purpose of the present study was to draw up the knowledge flow network of the Endocrinology and Metabolism Research Institute (EMRI) affiliated to Tehran University of Medical Sciences. Methods The present study is a descriptive cross-sectional study on the publications of the EMRI. Web of Science Core collection databases were searched for the EMRI publications between 2002 to November 2019. Besides, publications were classified and visualized based on authorships (institutes and country of affiliation), and keywords (cooccurrence and trend). Scientometric methods including VOSviewer and HistCite were used for descriptive statistics and data analysis. Results Total citations to the records were 47,528 and papers were published in 916 journals. The annual growth rate of publications and the citation was 14.2% and 18.9%, respectively. A total of 9466 authors from 136 countries collaborated in the publications. The co-authorship patterns showed that the average co-authorship and collaboration coefficient was 3.3 and 0.19. Conclusion Knowledge flow between EMRI researchers with international collaborations, engagement with leading countries, and interdisciplinary collaborations have an increasing trend. To develop a full picture of co-authorship, using social network analysis indicators are suggested for future studies.

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Section: Discussionmentioning

confidence: 99%

Visualization of knowledge flow in interpersonal scientific collaboration network endocrinology and metabolism research institute

Shahmoradi

Ramezani

Atlasi

et al. 2020

J Diabetes Metab Disord

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“…Accordingly, among these methods, electrochemical sensing approaches have received much attention due to their easiness, high sensitivity, selectivity, and inexpensive determination of medical biomolecules [8]. As well, it is believed that the electrochemical method can be applied as a reliable method for the detection of medical analytes such as amino acids and neurotransmitters in the clinical lab [9]. In addition, nanomaterials-based electrochemical sensing of both Trp and 5-HT have been exclusively investigated in order to determine their levels in both animal models and biological uid of the human body.…”

Section: Determination Methodsmentioning

confidence: 99%

Are Tryptophan and Serotonin Alteration Act as a Trigger Biomarker for Type 2 Diabetes Complications?

Khoshnevisan

Chehrehgosha

Sajjadi-Jazi

2021

Preprint

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Tryptophan (Trp) is a vital amino acid causing clinical implications in the human body and biological specimens. Serotonin (5-HT) is well-recognized for its biological activities in the brain, and as a familiar neurotransmitter, it regulates various neuropsychological processes. Alterations in the serotonergic system were proved to play a role in the pathogenesis of different neurological and psychiatric diseases. In recent years, Trp and 5-HT levels have been considered as triggers of diabetes mellitus (DM). The altered Trp metabolism may also play roles in the pathogenesis of DM and developing a risk of complications. The whole blood (WB) 5-HT level was mainly lower among diabetic patients compared to others. That is mostly derived from a lower platelet concentration of 5-HT in these patients. Indeed, 5-HT level can be considered as a potent biomarker for early detection of DM complications. Besides, it was proved that outside the digestive and central nervous systems, 5-HT was discovered in beta cells, and scientists have been attempting to realize its mechanism of action ever since. Towards to end, the determination methods, biomarker’s role, and approaches of 5-HT and Trp levels were thoroughly investigated in both healthy and diabetic patients with or without complications. Moreover, the association between insulin and 5-HT has been specifically discussed. Our study concluded that Trp and 5-HT levels could be exclusively applied for early diagnosis of DM complications as well as many other complications.

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“…High levels of 5‐HT have been linked to several disorders (particularly migraine and anxiety), and inadequate 5‐HT levels play a significant role in depression and obsessive/compulsive behaviour (Abbaspour & Noori, 2011; Khoshnevisan, Honarvarfard, et al, 2020; Lai et al, 2021; Mao et al, 2012).…”

Section: Trp Metabolites; Biomarkers In Various Disordersmentioning

confidence: 99%

Interactive relationship between Trp metabolites and gut microbiota: The impact on human pathology of disease

Khoshnevisan

Chehrehgosha

Conant

et al. 2022

Journal of Applied Microbiology

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Tryptophan (Trp), an α‐amino acid, is the precursor of serotonin (5‐hydroxytryptamine, 5‐HT), which is involved in a variety of features of metabolic function and human nutrition. Evidence highlights the role of Trp metabolites (exclusively 5‐HT) in the gastrointestinal (GI) tract; however, the mechanisms of action involved in the release of 5‐HT in the GI tract are still unknown. Considering the fact that variations of 5‐HT may facilitate the growth of certain GI disorders, gaining a better understanding of the function and release of 5‐HT in the GI tract would be beneficial. Additionally, investigating Trp metabolism may clarify the relationship between Trp and gut microbiota. It is believed that other metabolites of Trp (mostly that of the kynurenine pathway) may play a significant role in controlling gut microbiota function. In this review, we have attempted to summarize the current research investigating the relationship of gut microbiota, Trp and 5‐HT metabolism (with particular attention paid to their metabolite type, as well as a discussion of the research methods used in each study). Taking together, regarding the role that Trp/5‐HT plays in a range of physical and mental diseases, the gut bacterial types, as well as the related disorders, have been exclusively considered.

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Electrochemical detection of serotonin: A new approach

Cited by 60 publications

References 77 publications

Visualization of knowledge flow in interpersonal scientific collaboration network endocrinology and metabolism research institute

Visualization of knowledge flow in interpersonal scientific collaboration network endocrinology and metabolism research institute

Are Tryptophan and Serotonin Alteration Act as a Trigger Biomarker for Type 2 Diabetes Complications?

Interactive relationship between Trp metabolites and gut microbiota: The impact on human pathology of disease

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