Electrochemical Detection of Pathogenic Bacteria—Recent Strategies, Advances and Challenges

Kuss, Sabine; Amin, Hatem M. A.; Compton, Richard G.

doi:10.1002/asia.201800798

Cited by 85 publications

(50 citation statements)

References 73 publications

(192 reference statements)

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“…Viral infections mostly occur through contaminated water, food, and/or bodily fluids, spread rapidly and result in death of humans and animals worldwide. 1,2 Significant concerns has raised due to the increased viral outbreaks, since the viruses could quickly spread and cause a pandemic. Thus, rapid and accurate detection can mean the difference between life and death during viral infections.…”

Section: The Challenge Of Viral Diseases Worldwidementioning

confidence: 99%

Review—Chemical and Biological Sensors for Viral Detection

Özer

Geiss

Henry

2019

J. Electrochem. Soc.

122

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Infectious diseases commonly occur in contaminated water, food, and bodily fluids and spread rapidly, resulting in death of humans and animals worldwide. Among infectious agents, viruses pose a serious threat to public health and global economy because they are often difficult to detect and their infections are hard to treat. Since it is crucial to develop rapid, accurate, cost-effective, and in-situ methods for early detection viruses, a variety of sensors have been reported so far. This review provides an overview of the recent developments in electrochemical sensors and biosensors for detecting viruses and use of these sensors on environmental, clinical and food monitoring. Electrochemical biosensors for determining viruses are divided into four main groups including nucleic acid-based, antibody-based, aptamer-based and antigen-based electrochemical biosensors. Finally, the drawbacks and advantages of each type of sensors are identified and discussed.

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Section: The Challenge Of Viral Diseases Worldwidementioning

confidence: 99%

Review—Chemical and Biological Sensors for Viral Detection

Özer

Geiss

Henry

2019

J. Electrochem. Soc.

122

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“…At present, sensors based on resonant microweighting are capable of measuring the change in mass attached to objects cantilever with an accuracy of several attograms [125]. Moreover, the use of the resonant microbalance method can significantly reduce measurement time.…”

Section: Mechanical Biosensorsmentioning

confidence: 99%

Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends

et al. 2020

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Infections pose a serious global public health problem and are a major cause of premature mortality worldwide. One of the most challenging objectives faced by modern medicine is timely and accurate laboratory-based diagnostics of infectious diseases. Being a key factor of timely initiation and success of treatment, it may potentially provide reduction in incidence of a disease, as well as prevent outbreak and spread of dangerous epidemics. The traditional methods of laboratory-based diagnostics of infectious diseases are quite time- and labor-consuming, require expensive equipment and qualified personnel, which restricts their use in case of limited resources. Over the past six decades, diagnostic technologies based on lateral flow immunoassay (LFIA) have been and remain true alternatives to modern laboratory analyzers and have been successfully used to quickly detect molecular ligands in biosubstrates to diagnose many infectious diseases and septic conditions. These devices are considered as simplified formats of modern biosensors. Recent advances in the development of label-free biosensor technologies have made them promising diagnostic tools that combine rapid pathogen indication, simplicity, user-friendliness, operational efficiency, accuracy, and cost effectiveness, with a trend towards creation of portable platforms. These qualities exceed the generally accepted standards of microbiological and immunological diagnostics and open up a broad range of applications of these analytical systems in clinical practice immediately at the site of medical care (point-of-care concept, POC). A great variety of modern nanoarchitectonics of biosensors are based on the use of a broad range of analytical and constructive strategies and identification of various regulatory and functional molecular markers associated with infectious bacterial pathogens. Resolution of the existing biosensing issues will provide rapid development of diagnostic biotechnologies.

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“…Bacterial detection techniques usually employ antibodies (labelled or un-labelled), enzymes, DNAs or even a whole cell (micro-organism) as the bioreceptors, [76] but also redox mediator-assisted electrochemical sensing has been reported. [76] The classical procedure of living bacterial cell detection with redox indicators is based on the metabolic consumption (cellular reduction) of the redox indicator (i. e., a compound that can be reduced by the uptake of an electron) by the respiratory electron transport chain of living bacterial cells. [77,78] The consumption of the redox indicator is time-dependent and can be used for the detection and quantification of living bacterial cells in a liquid sample.…”

Section: Living Bacterial Cell Detectionmentioning

confidence: 99%

Highly Loaded Mildly Edge‐Oxidized Graphene Nanosheet Dispersions for Large‐Scale Inkjet Printing of Electrochemical Sensors

et al. 2020

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Inkjet printing of electrochemical sensors using a highly loaded mildly edge-oxidized graphene nanosheet (EOGN) ink is presented. An ink with 30 mg/mL EOGNs is formulated in a mixture of N-methyl pyrrolidone and propylene glycol with only 30 min of sonication. The absence of additives, such as polymeric stabilizers or surfactants, circumvents reduced electrochemical activity of coated particles and avoids harsh postprinting conditions for additive removal. A single light pulse from a xenon flash lamp dries the printed EGON film within a fraction of a second and creates a compact electrode surface.An accurate coverage with only 30.4 μg of EOGNs per printed layer and cm 2 is achieved. The EOGN films adhere well to flexible polyimide substrates in aqueous solution. Electrochemical measurements were performed using cyclic voltammetry and differential pulse voltammetry. An all inkjet-printed threeelectrode living bacterial cell detector is prepared with EOGN working and counter electrodes and silver-based quasi-reference electrode. The presence of E. coli in liquid samples is recorded with four electroactive metabolic activity indicators.

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Electrochemical Detection of Pathogenic Bacteria—Recent Strategies, Advances and Challenges

Cited by 85 publications

References 73 publications

Review—Chemical and Biological Sensors for Viral Detection

Review—Chemical and Biological Sensors for Viral Detection

Label-Free Biosensors for Laboratory-Based Diagnostics of Infections: Current Achievements and New Trends

Highly Loaded Mildly Edge‐Oxidized Graphene Nanosheet Dispersions for Large‐Scale Inkjet Printing of Electrochemical Sensors

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