“…3 Among those explorations, o -aminophenyl and o -hydroxyphenyl-substituted p -QMs I (X = OH, NHR) bearing an exocyclic nucleophilic motif at the C8 position have been generally used as a four-atom synthon in the development of (4+ n ) annulations (Scheme 1a). 3 b – e ,4 Besides, typical aryl-substituted p -QMs I (X = H, R) directly acting as a C2 synthon have been disclosed in a series of type I (2+ n ) annulations occurring at C5 and C6 (Scheme 1a). 5 However, there is no report on exploring p -QMs as a positional isomeric C2 synthon in alternative (2+ n ) annulations.…”