Electrochemical construction of a bio-inspired micro/nano-textured structure with cell-sized microhole arrays on biomedical titanium to enhance bioactivity

Liang, Jiyuan; Song, Ran; Huang, Qiaoling; Yang, Yun Jung; Lin, Lu‐Yin; Zhang, Yanmei; Jiang, Pinliang; Duan, Huajun; Dong, Xiang; Lin, Changjian

doi:10.1016/j.electacta.2015.06.100

Cited by 38 publications

(33 citation statements)

References 64 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rough surfaces may be better to increase the biomaterial‐tissue interlocking and enhance cell differentiation than the smooth surfaces . As shown in Figure b–d, many microholes appeared on the MN–Ti, Zn–MN–Ti, and Sr–MN–Ti surfaces, which were similar to a bowl‐shaped nest and would be benefit to the mechanical anchoring of cells . In a word, the Ti substrate with micro/nanostructure has a rough surface and many microholes, which would favors the adhesion and proliferation of cells.…”

Section: Resultsmentioning

confidence: 96%

“…Furthermore, the viability of cells grown onto the MN–Ti sample was statistically higher than that of the Cp–Ti sample after culture for 5 days. It was demonstrated that the micro/nanostructure had a positive effect on the proliferation of cells . In particular, Zn–MN–Ti and Sr–MN–Ti substrartes exhibited greater potential to promote cell proliferation than MN–Ti substrate.…”

Section: Resultsmentioning

confidence: 99%

“…In previous studies, many efforts have been made by researchers to enhance osseointegration, including surgical technique improvement, longer healing period, and surface modification . Since surface characteristics are of vital importance to regulate biological responses, various surface treatment methods have been proposed and employed to promote bone formation at the implant‐bone interface …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surface Functionalization of Micro/Nanostructured Titanium with Bioactive Ions to Regulate the Behaviors of Murine Osteoblasts

et al. 2017

View full text Add to dashboard Cite

Surface topography and chemical composition are centrally important in current implants for enhancing cellular responses. To investigate the synergistic effect of micro/nanostructure and bioactive ions on the spreading, proliferation, and differentiation of murine osteoblasts, the micro/nanostructured titanium surface containing bioactive ions (Zn 2þ and Sr 2þ ) was fabricated via sandblasting, acid etching, alkali-heat treatment, and ion exchange. Compared to polished titanium substrates, micro/ nanostructured titanium substrates displayed the enhanced roughness and hydrophilicity. And surface functionalization of micro/nanostructured using Zn 2þ /Sr 2þ ions exhibited the sustained release for a period of time. Meanwhile, cell experiments indicated that the Zn/Sr loaded micro/ nanostructured titanium surfaces had a great potential to promote cell spreading, proliferation, and differentiation. This study provides a more promising method to design the surface of titanium implants for enhancing osseointegration.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surface Functionalization of Micro/Nanostructured Titanium with Bioactive Ions to Regulate the Behaviors of Murine Osteoblasts

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The latter in turn leads to low osteointegration and to the formation of a fibrous tissue, a process which culminates in implant failure. Different methodologies have been proposed to modify the surface of Ti in order to improve osteointegration (Liang et al 2015;Velasco-Ortega et al 2016).…”

Section: Biomimetic Modification Of the Surface Of Timentioning

confidence: 99%

The role played by modified bioinspired surfaces in interfacial properties of biomaterials

et al. 2017

View full text Add to dashboard Cite

The success of a biomaterial relies on an appropriate interaction between the surface of that biomaterial and the surrounding environment; more specifically, the success of a biomaterial depends on how fluids, proteins, and cells interact with the foreign material. For this reason, the surface properties of biomaterial, such as composition, charge, wettability, and roughness, must be optimized for a desired application to be achieved. In this review we highlight different bioinspired approaches that are used to manipulate and fine-tune the interfacial properties of biomaterials. Inspired by noteworthy natural processes, researchers have developed materials with a functional anatomy that range from hierarchical hybrid structures to self-cleaning interfaces. In this review we focus on (1) the creation of particles and modified surfaces inspired by the structure and composition of biogenic mineralized tissues, (2) the development of biofunctional coatings, (3) materials inspired by biomembranes and proteins, and (4) the design of superwettable materials. Our intention is to point out different bioinspired methodologies that have been used to design materials for biomedical applications and to discuss how interfacial properties modified by manipulation of these materials determine their final biological response. Our objective is to present future research directions and to highlight the potential of bioinspired materials. We hope this review will provide an understanding of the interplay between interfacial properties and biological response so that successful biomaterials can be achieved.

show abstract

“…A number of studies have proved that strategies, such as engineering surface topography (micro/nanostructures), [19][20][21] calcium phosphate coatings, 7,22,23 metallic elements, 24,25 extracellular matrix (ECM) proteins, 26,27 biomolecular coatings incorporating growth factors, [28][29][30] and so forth, can distinctly promote osseointegration by positively regulate cell adhesion, proliferation, and differentiation. Independently, growth factors play important roles in tissue repair and regeneration.…”

Section: Introductionmentioning

confidence: 99%

Preparing and immobilizing antimicrobial osteogenic growth peptide on titanium substrate surface

Liu

Yang

Tao

et al. 2018

J Biomedical Materials Res

View full text Add to dashboard Cite

The inherent bioinertness and potential bacterial infection risk are the two leading causes for Ti implant failure. To improve osseointegration and antibiosis, in this work, a novel antimicrobial osteogenic growth peptide was first synthesized by conjugating osteogenic growth peptide (OGP) and ciprofloxacin (CIP). Then, the synthetic antimicrobial peptide was immobilized onto Ti implant surface for chemoselective binding via the amide reaction. Thereafter, the capabilities of modified Ti implant on osseointegration and antibiosis were measured with cell experiments and antimicrobial activity in vitro. The results showed that antimicrobial osteogenic growth peptide (OGP-CIP) was successfully prepared and grafted onto Ti implant surface. Moreover, the antimicrobial peptide-modified Ti implants could promote osteoblasts spreading and osteodifferentiation compared with unmodified Ti substrates. Meanwhile, in vitro bacteria studies (Staphylococcus aureus and Escherichia coli) proved that the antibacterial property of antimicrobial peptide functionalized Ti implant was improved obviously. The method used in this work is a feasible and promising strategy to win the race against invading bacteria and accelerate bone integration in orthopedic implantation. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3021-3033, 2018.

show abstract

Electrochemical construction of a bio-inspired micro/nano-textured structure with cell-sized microhole arrays on biomedical titanium to enhance bioactivity

Cited by 38 publications

References 64 publications

Surface Functionalization of Micro/Nanostructured Titanium with Bioactive Ions to Regulate the Behaviors of Murine Osteoblasts

Surface Functionalization of Micro/Nanostructured Titanium with Bioactive Ions to Regulate the Behaviors of Murine Osteoblasts

The role played by modified bioinspired surfaces in interfacial properties of biomaterials

Preparing and immobilizing antimicrobial osteogenic growth peptide on titanium substrate surface

Contact Info

Product

Resources

About