Electrochemical characterization of coatings for local prevention of Candida infections on titanium-based biomaterials

Toirac, Beatriz; García-Casas, Amaya; Cifuentes, Sandra C.; Aguilera-Correa, John Jairo; Esteban, Jaime; Mediero, Aránzazu; Jiménez-Morales, Antonia

doi:10.1016/j.porgcoat.2020.105681

Cited by 12 publications

(10 citation statements)

References 71 publications

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“…Last, no significant effects were found on cytotoxicity and proliferation. This is in contrast with previous works where fluconazole-loaded coatings displayed slight cytotoxicity [ 28 ]. However, those coatings were not functionalized with phosphorous compounds.…”

Section: Discussioncontrasting

confidence: 98%

“…In a subsequent work using in vitro and in vivo experiments, the addition of moxifloxacin to the coatings proved to effectively prevent bacterial implant infections [ 27 ]. In another work, fluconazole and anidulafungin-loaded coatings without the addition of phosphorus compounds were characterized electrochemically and the release of both antifungals was evaluated [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

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A Biodegradable Antifungal-Loaded Sol–Gel Coating for the Prevention and Local Treatment of Yeast Prosthetic-Joint Infections

et al. 2020

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Fungal prosthetic-joint infections are rare but devastating complications following arthroplasty. These infections are highly recurrent and expose the patient to the development of candidemia, which has high mortality rates. Patients with this condition are often immunocompromised and present several comorbidities, and thus pose a challenge for diagnosis and treatment. The most frequently isolated organisms in these infections are Candida albicans and Candida parapsilosis, pathogens that initiate the infection by developing a biofilm on the implant surface. In this study, a novel hybrid organo–inorganic sol–gel coating was developed from a mixture of organopolysiloxanes and organophosphite, to which different concentrations of fluconazole or anidulafungin were added. Then, the capacity of these coatings to prevent biofilm formation and treat mature biofilms produced by reference and clinical strains of C. albicans and C. Parapsilosis was evaluated. Anidulafungin-loaded sol–gel coatings were more effective in preventing C. albicans biofilm formation, while fluconazole-loaded sol–gel prevented C. parapsilosis biofilm formation more effectively. Treatment with unloaded sol–gel was sufficient to reduce C. albicans biofilms, and the sol–gels loaded with fluconazole or anidulafungin slightly enhanced this effect. In contrast, unloaded coatings stimulated C. parapsilosis biofilm formation, and loading with fluconazole reduced these biofilms by up to 99%. In conclusion, these coatings represent a novel therapeutic approach with potential clinical use to prevent and treat fungal prosthetic-joint infections.

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Section: Discussioncontrasting

confidence: 98%

Section: Introductionmentioning

confidence: 99%

A Biodegradable Antifungal-Loaded Sol–Gel Coating for the Prevention and Local Treatment of Yeast Prosthetic-Joint Infections

et al. 2020

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“… Cerqueira et al (2020) used sol-gel coatings as a release agent for MLT on a titanium substrate, they found that it didn’t improve the ALP activity, but has the potential in the activation and development of pathways. Based on the sol-gel coating, Toirac et al (2020) added two different fungicides (fluconazole and anidulafungin) directly both of them exhibited anti-fungal properties.…”

Section: Chemical Modificationmentioning

confidence: 99%

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

Xue

Attarilar

Liu

et al. 2020

Front. Bioeng. Biotechnol.

136

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Depending on the requirements of specific applications, implanted materials including metals, ceramics, and polymers have been used in various disciplines of medicine. Titanium and its alloys as implant materials play a critical role in the orthopedic and dental procedures. However, they still require the utilization of surface modification technologies to not only achieve the robust osteointegration but also to increase the antibacterial properties, which can avoid the implant-related infections. This article aims to provide a summary of the latest advances in surface modification techniques, of titanium and its alloys, specifically in biomedical applications. These surface techniques include plasma spray, physical vapor deposition, sol-gel, micro-arc oxidation, etc. Moreover, the microstructure evolution is comprehensively discussed, which is followed by enhanced mechanical properties, osseointegration, antibacterial properties, and clinical outcomes. Future researches should focus on the combination of multiple methods or improving the structure and composition of the composite coating to further enhance the coating performance.

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“…The deposition of a silane coating could control the corrosion of Mg alloys, although it could dissolve in contact with water due to the hydrolysis of the polysiloxane (Si▬O▬Si) network [20] that results in the release of silicic acid (Si(OH) 4 ), which can be expressed as follows [21]:…”

Section: Corrosion Behavior Of Mg Alloys In Aqueous Environmentmentioning

confidence: 99%

The Role of Silane Sol-Gel Coatings on the Corrosion Protection of Magnesium Alloys

Merino¹,

Durán²,

Castro³

2022

Current Trends in Magnesium (Mg) Research

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Magnesium alloys, as the lightest structural metallic material with promising physical, mechanical, and biodegradable properties, have become very attractive for different technical applications, especially for industrial and biomedical fields. However, rapid corrosion is the most critical obstacle that limits its use to play a major role in large-scale applications. The simplest way to control the corrosion rate is to prevent a direct contact of the magnesium substrate with the environment by using surface modification technologies. Silica sol-gel coatings are considered a promising solution to enhance the corrosion resistance of magnesium alloys because sol-gel-based coating systems form very stable chemical bonds with the metallic surface. In this chapter, an insight about the advances in silica sol-gel coatings as an alternative method to control the corrosion of Mg and its alloys will be exposed. A wide overview of the most relevant aspects and their current applications, specifically for aerospace, automobile, and biomedical applications will be described. The modification of silica sol-gel matrix by the incorporation of different types of inhibitors to achieve an active barrier property on Mg alloys has been also considered. Finally, the future perspective based on the development of new silica sol-gel coatings on Mg alloy will be presented.

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Electrochemical characterization of coatings for local prevention of Candida infections on titanium-based biomaterials

Cited by 12 publications

References 71 publications

A Biodegradable Antifungal-Loaded Sol–Gel Coating for the Prevention and Local Treatment of Yeast Prosthetic-Joint Infections

A Biodegradable Antifungal-Loaded Sol–Gel Coating for the Prevention and Local Treatment of Yeast Prosthetic-Joint Infections

Surface Modification Techniques of Titanium and its Alloys to Functionally Optimize Their Biomedical Properties: Thematic Review

The Role of Silane Sol-Gel Coatings on the Corrosion Protection of Magnesium Alloys

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