Electrochemical characterization of a novel nimesulide anti-inflammatory drug analog: LQFM-091

Leite, Karla Carneiro de Siqueira; Garcia, Luane Ferreira; Sanz, Germán; Colmati, Flávio; Souza, Aparecido Ribeiro de; Batista, Daniel da Costa; Menegatti, Ricardo; Gil, Eric de Souza; Luque, Rafael

doi:10.1016/j.jelechem.2018.04.033

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Concerning the study of drug redox features, electrochemical methods such as voltammetry are highly regarded, since both kinetics and thermodynamics are readily assayed using minute solvent volumes. These tools provide information about the redox behavior of the compounds, as well as correlated chemical phenomena [4,5]. Moreover, electrochemistry grants information regarding the oxidative degradation of these compounds [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Characterization of Central Action Tricyclic Drugs by Voltammetric Techniques and Density Functional Theory Calculations

et al. 2019

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This work details the study of the redox behavior of the drugs cyclobenzaprine (CBP), amitriptyline (AMP) and nortriptyline (NOR) through voltammetric methods and computational chemistry. Results obtained in this study show that the amine moiety of each compound is more likely to undergo oxidation at 1a at Ep1a ≈ 0.69, 0.79, 0.93 V (vs. Ag/AgCl/KClsat) for CBP, AMP and NOR, respectively. Moreover, CBP presented a second peak, 2a at Ep2a ≈ 0.98 V (vs. Ag/AgCl/KClsat) at pH 7.0. Furthermore, the electronic structure calculation results corroborate the electrochemical assays regarding the HOMO energies of the lowest energy conformers of each molecule. The mechanism for each anodic process is proposed according to electroanalytical and computational chemistry findings, which show evidence that the methods herein employed may be a valuable alternative to study the redox behavior of structurally similar drugs.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Characterization of Central Action Tricyclic Drugs by Voltammetric Techniques and Density Functional Theory Calculations

et al. 2019

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Electroanalytical Investigation of Nimesulide by Differential Pulse Polarography: Method Validation

Patil¹

2021

SSRN Journal

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Past, Present and Future of Electroanalytical Sensor for Aspirin, Ibuprofen and Paracetamol Detection

Kang

Hong

et al. 2022

CPA

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Background: Pain not only affects quality of life but can also lead to people suffering from mental illness due to the lack of effective treatment for long-term pain. Analgesics refer to drugs that can partially or completely relieve pain, including non-steroidal anti-inflammatory drugs and central analgesics. Methods: In recent years, the cross integration of electrochemical analysis technology with biochemistry, materials science, biomedicine and other disciplines has driven the vigorous development of electrochemical sensing technology in the field of life sciences. The electrochemical sensor has many advantages, such as simple equipment, good specificity, high sensitivity, economy and convenience. As a newly emerging technology, electrochemical sensing technology is increasingly widely used in drug analysis. Results: This review introduces the recent advances of the detection of analgesics using electrochemical technology. We deliberately selected three representative drugs for discussion: aspirin, ibuprofen and paracetamol. Conclusion: Electrochemical sensing technology has the advantages of high sensitivity, a low detection limit and simple operation. However, sensors still have some technical problems, such as the existence of many interference factors in actual samples in blood drug concentration monitoring and the need for the further optimization of the method conditions for multi-channel detection. With the continuous advancement of research, the application of new detection methods, nanomaterials, and biomolecules has enabled electrochemical technology to make certain progress in the field of drug analysis. In particular, the emergence of new nanomaterials will greatly promote the development of electrochemical sensing technology in drug analysis. As a cutting-edge technology, electrochemical sensing technology has enormous potential application value.

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Electrochemical characterization of a novel nimesulide anti-inflammatory drug analog: LQFM-091

Cited by 4 publications

References 19 publications

Electrochemical Characterization of Central Action Tricyclic Drugs by Voltammetric Techniques and Density Functional Theory Calculations

Electrochemical Characterization of Central Action Tricyclic Drugs by Voltammetric Techniques and Density Functional Theory Calculations

Electroanalytical Investigation of Nimesulide by Differential Pulse Polarography: Method Validation

Past, Present and Future of Electroanalytical Sensor for Aspirin, Ibuprofen and Paracetamol Detection

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