Electrochemical Characterization and Voltammetric Determination of Benzoyl Derivatives of Phenobarbital Using Glassy Carbon Electrode

Abstract

The electrochemical behavior of a number of benzoyl barbiturates was studied using a glassy carbon electrode (GCE). The kinetics of the electrode process is determined, the contribution of physical adsorption to the electrochemical process is estimated, and the mechanism of the possible electrochemical reaction is proposed. It is shown that the electrochemical reduction potentials of benzoyl phenobarbital derivatives are determined by the LUMO energies, calculated by the B3LYP 6‐311+G method. It is established that the process is quasi‐reversible, complicated by adverse reactions. The influence of halogen type and its position in the benzoyl residue of the studied substances on the analytical signal is established. The effective values of the dissociation constants of various forms of benzoyl derivatives were calculated using the example of halonal, for which the values 3.16 ⋅ 10−8 and 6.31 ⋅ 10−12, respectively, were found.

Interpol Review of Drug Analysis 2019-2022

“…2019 Electrochemical characterization and voltammetric determination of benzoyl derivatives of phenobarbital using glassy carbon electrode [ 238 ]; sensor for detection of phenobarbital [ 239 ]; 2020 SERS method for detecting low concentrations of phenobarbital using a commercially available portable Raman module [ 240 ]; 2022 electrochemical sensor for determination of phenobarbital [ 241 ]; fluorescence nanoprobe for the detection of phenobarbital [ 242 ]; sensor for determination of phenobarbital in pharmaceutical, blood and urine samples [ 243 ].…”