Electrochemical Characterization and Quantification of the Strong Antioxidant and Antitumor Agent Pomiferin

Abstract

The electrochemical behavior of pomiferin, a natural isoflavone with significant antioxidant, antidiabetic and antitumor properties, is reported here for the first time at a glassy carbon electrode (GCE). In order to understand the redox processes of this compound, its response was compared with the nonantioxidant isoflavone osajin. Based on cyclic and square-wave voltammetric methods it was observed that pomiferin presents a quasireversible anodic peak, which was attributed to the oxidation of the catechol group, and that is strongly influenced by pH. This anodic process yields a well-defined DPV response, which can be used for the analytical determination of this potential pharmotherapeutic isoflavone.

Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltammetry

“…This lower electrochemical anodic peak (generally lower than 0.50 V) has already been reported in the flavonoid family on a glassy carbon electrode at neutral pH versus Ag/ AgCl. 10,[21][22][23] The results suggest that the D-catechol unit of the studied xanthones is more susceptible to oxidation than the Ecatechol moiety. Thus, compound XH3 (D-catechol, E p1a = 0.16 V) presented a lower oxidation peak than compound XH7 (E-catechol, E p1a = 0.18 V) and the same is observed for compounds XH6 and XH8 (E p1a = 0.16 V and 0.18 V, respectively).…”

“…Their operating simplicity, higher sensitivity, short time of analysis, and lower reagent consuming as well as lower costs are some advantages presented by these techniques compared with chromatographic or spectroscopic methods. 10,11 Thus cyclic voltammetry (CV) has become an important and widely used electroanalytical technique in many relevant studies of redox processes, in organic and inorganic chemistry, to clarify the electrochemical behavior of complex chemical and biochemical systems, and to obtain information about all types of interfacial processes depending on electrochemical currents. 12 The aim of the present study is to study the electrochemical In order to simulate the physiological conditions, the cyclic voltammograms were performed at pH 7.4 (sodium phosphate).…”

Voltammetric behaviour and square-wave voltammetric determination of the potent antioxidant and anticarcinogenic agent ellagic acid in foodstuffs

“…SWV is a technique that combines the best aspects of several pulse voltammetric methods (Bard & Faulkner, 2001), which results in a fast technique that is widely applied as analytical tool for the determination of bioactive compounds (Adam et al, 2007;Novak, Seruga, & Komorsky-Lovric, 2009;Teixeira, Dias, & Teixeira, 2009). In this paper, a SWV method for the determination of EA and its application to the analysis of different foodstuffs, e.g.…”

Electrochemical Oxidation Mechanisms of the Antioxidants Daidzein and 7‐Hydroxy‐4‐chromone

“…Flavonoids are one of the more important groups of natural pharmotherapeutic compounds and the largest family of phenolic compounds [1], comprising several sub-classes, which include a great number of compounds with different chemical properties: flavonols, flavones, flavanols and isoflavones. Flavonoids consist of two benzene rings linked by an oxygen containing heterocycle, Scheme 1, and are characterized by the number of hydroxyl groups on the A-and B-rings.…”

“…These compounds have important health protecting properties, such as antioxidant, anti-inflammatory, antiallergic, antibacterial, antiparasitic antifungal, antimicrobial, antidiabetic and anticarcinogenic properties. It is well known that antioxidants reduce the risk of chronic diseases, including coronary diseases and cancer, and anticarcinogenic substances, among various effects, can induce apoptosis destroying tumor cells, [1,2].…”