Electrochemical characteristics of bioresorbable binary MgCa alloys in Ringer's solution: Revealing the impact of local pH distributions during in-vitro dissolution

Mareci, Daniel; Bolat, G.; Izquierdo, Javier; Crimu, Carmen Iulia; Munteanu, Corneliu; Antoniac, Iulian Vasile; Souto, Ricardo M.

doi:10.1016/j.msec.2015.11.069

Cited by 52 publications

(20 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For the scaffold of a bioabsorbable coronary artery stent, new Mg-based alloys, such as wrought Mg-Nd-Sr-Zr, Mg-Gd-Nd-Zn-Zr, and Fe-35Mn alloys, powder-metallurgy Fe-Au and Fe-Ag alloys, and highly-porous Mg-Y and Mg-Y-Zn-Ca-Mn alloys are being evaluated [71][72][73][74]. New alloys that show good potential for applications as both bioresorbable TJRs and coronary artery stent scaffolds include Mg-0.63 Ca and Mg-0.89Ca [75]. As the fifth suggestion, studies should be conducted on deposition of nanoHA on the substrate of each of these new alloys and the full panoply of characterization tests of the coating and of the coated bioalloy specimen should be performed.…”

Section: Directions For Future Researchmentioning

confidence: 99%

Nanostructured Hydroxyapatite Coating on Bioalloy Substrates: Current Status and Future Directions

Lewis¹

2017

JAN

View full text Add to dashboard Cite

Abstract. Several shortcomings of the alloys that are used to fabricate a number of currentgeneration biomedical implants, such as Ti-6Al-4V alloy for the femoral stem of a total hip replacement and AZ3 Mg alloy for the scaffold of a fully bioabsorbable coronary artery stent, are well-known. Examples of these shortcomings are limited bioactivity/osseointegration (in the case of Ti-based alloys) and high corrosion rate (in the case of Mg-based alloys). It is now recognized that a nanostructured hydroxyapatite (nanoHA) coating on the substrate of a bioalloy can increase bioactivity and reduce corrosion of the substrate. A large number of nanoHA deposition methods and a variety of characterization techniques/methods have been used to obtain an assortment of properties of the coating, the coated specimens, and the coating-substrate interface. Examples of these deposition methods are electrophoretic deposition and radiofrequency magnetron sputtering and some of the most frequently used characterization techniques/methods are x-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, scanning electron microscopy, atomic force microscopy, immersion tests in a biosimulating solution at 37 o C, and culturing in cells extracted from humans. Among the properties obtained are the morphology, thickness, size of the nanoHA; degree of crystallinity of the coating; and the adhesive strength and corrosion rate in an aqueous biosimulating solution at 37 o C. The present work is a comprehensive review of the very large body of literature in this field, with the focal topics being essential steps in a deposition method, discussion of the influence of deposition method variables on myriad coating properties (for a given deposition method), and identification of the shortcomings of the literature, and, hence, outlines of ten suggested directions for future research.

show abstract

Section: Directions For Future Researchmentioning

confidence: 99%

Nanostructured Hydroxyapatite Coating on Bioalloy Substrates: Current Status and Future Directions

Lewis¹

2017

JAN

View full text Add to dashboard Cite

show abstract

“…Third, emerging methods for depositing nanoHA coating on biomedical alloys should be explored on Mg-based materials currently used for fabricating FBRSs (that is, Mg and WE43) or may be used for such a purpose (for example, Mg-2Al-1rare earth (Ce, Nd, Pt) [36], Mg-Nd-Zn-Sr-Zr alloy [89], Mg-0.63Ca and Mg-0.89Ca alloys [90]). Examples of these methods, which, herein, are defined as those that have been used to deposit nanoHA coating on Ti and its alloys that lead to marked reduction in corrosion rate, are aerosol deposition (ASD) [91] [92], electrohydrodynamic spray deposition (EHDSD) [93], and liquid precursor plasma spraying (LPPS) [94].…”

Section: Directions For Future Research Areasmentioning

confidence: 99%

“…This could be done using results of EIS and equivalent electrical circuits (EECs). Although the EIS-EEC approach has been used in a number of corrosion studies involving Mg and Mg alloy specimens in a variety of electrolytes [67] [72] [90], there is a shortcoming in this body work that should be corrected in the work to be conducted in this third potential research area. This is that there has not been any discussion of the principal limitation of the EIS-EEC approach, which is that the circuit presented is not unique [95].…”

Section: Directions For Future Research Areasmentioning

confidence: 99%

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Lewis¹

2016

WJET

View full text Add to dashboard Cite

The most popular treatment/management modality for coronary artery disease, which is one of the leading causes of death, is percutaneous transluminal coronary intervention (popularly known as "plain old balloon angioplasty") followed by implantation of a stent ("stenting"). Stent types have evolved from bare metal stents through first-generation drug-eluting stents to fully bioresorbable stents (FBRSs). Two examples of FBRSs are 1) Mg scaffold with no coating; and 2) Mg alloy scaffold coated with a bioresorbable polymer in which an anti-proliferative drug is embedded. In the case of Mg/Mg alloy FBRSs, one of the reported clinical results is that the resorption time of the stent is too short (<∼4 mo to ∼12 mo), a consequence of the high corrosion rate of the metal/alloy. The present review article contains 1) a summarized but comprehensive comparison and contrast of all the types of stents, with special reference to Mg/Mg alloy FBRSs; 2) a critical review of the body of literature on methods to reduce the corrosion rate of Mg/Mg alloy specimens in various aqueous biosimulating media that may have implications for plain Mg/Mg alloy FBRSs, examples of such methods being alloy chemistry modification and fabrication using a nanocomposite; and 3) directions for future work on Mg/Mg alloy FBRSs that draw upon the findings highlighted in item (2) above as well as on other ideas, such as utilization of a Mg matrix composite and fabrication using a metal additive manufacturing method. Thus, information given in this review may find use in work on decreasing the in vivo resorption time (and, hence, improving the clinical efficacy) of the current generation of fully-bioresorbable Mg/Mg-alloy stents as well as guide the development of the next generation of these stents.

show abstract

“…To extend its usability, the Mg has further been alloyed with different metals and biodegradable implants have been reached (Witte et al, 2006 ; Witte, 2010 ; Jafari et al, 2015 ). Recent investigations further show that the stabilities and durability of the metal and its alloys can be switched in at different ambiences, provided dedicated materials engineering is performed for the structural and compositional treatments (Jamesh et al, 2014 ; Mareci et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Microstructure Evolution in Mg-Zn-Zr-Gd Biodegradable Alloy: The Decisive Bridge Between Extrusion Temperature and Performance

et al. 2018

View full text Add to dashboard Cite

Being a biocompatible metal with similar mechanical properties as bones, magnesium bears both biodegradability suitable for bone substitution and chemical reactivity detrimental in bio-ambiences. To benefit its biomaterial applications, we developed Mg-2.0Zn-0.5Zr-3.0Gd (wt%) alloy through hot extrusion and tailored its biodegradability by just varying the extrusion temperatures during alloy preparations. The as-cast alloy is composed of the α-Mg matrix, a network of the fish-bone shaped and ellipsoidal (Mg, Zn)3Gd phase, and a lamellar long period stacking ordered phase. Surface content of dynamically recrystallized (DRXed) and large deformed grains increases within 330–350°C of the extrusion temperature, and decreases within 350–370°C. Sample second phase contains the (Mg, Zn)3Gd nano-rods parallel to the extrusion direction, and Mg2Zn11 nanoprecipitation when temperature tuned above 350°C. Refining microstructures leads to different anticorrosive ability of the alloys as given by immersion and electrochemical corrosion tests in the simulated body fluids. The sample extruded at 350°C owns the best anticorrosive ability thanks to structural impacts where large DRXed portions and uniform nanosized grains reduce chemical potentials among composites, and passivate the extruded surfaces. Besides materials applications, the in vitro mechanism revealed here is hoped to inspire similar researches in biometal developments.

show abstract

Electrochemical characteristics of bioresorbable binary MgCa alloys in Ringer's solution: Revealing the impact of local pH distributions during in-vitro dissolution

Cited by 52 publications

References 46 publications

Nanostructured Hydroxyapatite Coating on Bioalloy Substrates: Current Status and Future Directions

Nanostructured Hydroxyapatite Coating on Bioalloy Substrates: Current Status and Future Directions

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Microstructure Evolution in Mg-Zn-Zr-Gd Biodegradable Alloy: The Decisive Bridge Between Extrusion Temperature and Performance

Contact Info

Product

Resources

About