Electrochemical biosensors for neglected tropical diseases: A review

Cordeiro, Taís Aparecida Reis; Resende, Mayra Asevedo Campos de; Moraes, Simone Cristina dos Santos; Franco, Diego Leoni; Pereira, Arnaldo César; Ferreira, Lucas Franco

doi:10.1016/j.talanta.2021.122617

Cited by 26 publications

(27 citation statements)

References 209 publications

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“…For most tropical diseases, the best diagnostic methods are costly and time consuming. Biosensors for diagnosing NTDs are therefore of crucial importance [ 27 ].…”

Section: Mips Used For the Diagnosis Of Tropical Diseasesmentioning

confidence: 99%

“…MIP sensors are the result of several researches due to their many advantages including their high affinity and selectivity, ease of preparation or their low costs which will greatly accelerate the diagnosis and consequently the treatment [ 27 ]. These materials can be synthesized easily in any laboratory in the world, without any specific equipment.…”

Section: Mips Used For the Diagnosis Of Tropical Diseasesmentioning

confidence: 99%

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How Molecularly Imprinted Polymers can be Used for Diagnostic and Treatment of Tropical Diseases?

et al. 2022

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Molecularly imprinted polymers (MIPs) have been widely used in nanomedicine in the last few years. However, their use for diagnostic and treatment of tropical diseases is limited. Through this review, we aim to illustrate how MIPs were used to detect tropical disease and we show that they are not exploited enough in treatment. We finally show how MIPs could be used in the future in the treatment of tropical disease.

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“…For most tropical diseases, the best diagnostic methods are costly and time consuming. Biosensors for diagnosing NTDs are therefore of crucial importance [ 27 ].…”

Section: Mips Used For the Diagnosis Of Tropical Diseasesmentioning

confidence: 99%

Section: Mips Used For the Diagnosis Of Tropical Diseasesmentioning

confidence: 99%

How Molecularly Imprinted Polymers can be Used for Diagnostic and Treatment of Tropical Diseases?

et al. 2022

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“…These detection methods provide a simple, accurate, and rapid alternative that utilizes equipment readily available in hospitals worldwide; however, they are not ideal for point-of-care (POC) testing devices. POC devices are known for their portability and capability of in-field analysis, unlike other portable platforms …”

Section: Introductionmentioning

confidence: 99%

“…POC devices are known for their portability and capability of in-field analysis, unlike other portable platforms. 14 Electrochemical sensors further advance analytical techniques by offering a mobile, cheap, fast, and easy-to-use analysis method while providing high accuracy, selectivity, and sensitivity. 15,16 Glucose sensors are the most widely used electrochemical sensors that have revolutionized POC testing.…”

Section: ■ Introductionmentioning

confidence: 99%

Recent Advances in Electrochemical Tools for Virus Detection

et al. 2022

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Virus detection at the point-of-care facility has become an alarming topic in the research community. The latest coronavirus pandemic has highlighted the limitations of current conventional virus detection methods. Compared to nonelectrochemical sensors, electrochemical sensors provide the ideal platform for rapid, cheap, fast, sensitive, and selective diagnosis of several viruses, particularly at point-of-care facilities. This article highlights the most promising studies reported over the past decade to detect a broad spectrum of viruses using voltammetry, amperometry, and electrochemical impedance spectroscopy.

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“…Neglected tropical diseases (NTDs) are critical because they affect over 12% of the world population, with limited healthcare access in over 149 countries. 1 Human visceral leishmaniasis (VL) is the most severe form of a complex of leishmaniasis diseases. It can be caused by Leishmania donovani and Leishmania infantum (synonymous with Leishmania chagasi).…”

Section: ■ Introductionmentioning

confidence: 99%

Development and Validation of a SERS-Based Serological Test Combined with PLS-DA Method for Leishmaniasis Detection

Mancini

Sabaine

Castro

et al. 2022

ACS Appl. Electron. Mater.

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The fast and reliable anti-leishmaniasis antibody detection method was developed using citrate-capped gold nanoparticles (AuNPs) conjugated with an immunogenic peptide from promastigote surface antigens. These conjugates recognize specific antibodies that promote the aggregation of AuNPs in the solution, enabling a remarkable surface-enhanced Raman scattering (SERS) activity which allowed the development of an indirect detection test for human visceral leishmaniasis (VL). Dynamic and static light scattering methods were performed to investigate the aggregation process of the peptide-capped AuNPs induced by the addition of the specific polyclonal antibody anti-PSAdP23–47 in the diagnostic test. UV–vis spectroscopy and scanning electron microscopy demonstrated that AuNPs of different sizes are formed after interacting with antibodies against promastigote surface antigen (PSA)-derived peptides from the amino acid residues 23–47 (PSAdP23–47), confirmed by the plasmon resonance band position from 536 to 639 nm and light-scattering techniques. Experimental optimization of the SERS-based serological test showed that increasing the peptide and the citrate buffer concentration induces stronger Raman intensities. In addition, the multivariate curve resolution with alternating least squares allowed the identification of a fingerprint window within the range of 1043–1498 cm–1. Finally, a refined data analysis approach was successfully employed, enabling a robust differentiation between human sera from VL and non-VL patients. Prototype validation and proof of concept to demonstrate the feasibility and functionality of the sensor were carried out through calibration and optimization using a partial least squares discriminant analysis model with six latent variables, which validated the test reaching 100% sensitivity and 88.2% specificity. These results show the potential of the SERS platform for constructing a point-of-need serological test for diagnosing VL, a neglected tropical disease with a strong humoral immune response.

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Electrochemical biosensors for neglected tropical diseases: A review

Cited by 26 publications

References 209 publications

How Molecularly Imprinted Polymers can be Used for Diagnostic and Treatment of Tropical Diseases?

How Molecularly Imprinted Polymers can be Used for Diagnostic and Treatment of Tropical Diseases?

Recent Advances in Electrochemical Tools for Virus Detection

Development and Validation of a SERS-Based Serological Test Combined with PLS-DA Method for Leishmaniasis Detection

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