Electrochemical biosensors for monitoring of bioorganic and inorganic chemical pollutants in biological and environmental matrices

Azad, Uday Pratap; Mahapatra, Sebabrata; Divya, .; Srivastava, Ananya; Shetti, Nagaraj P.; Chandra, Pranjal

doi:10.1016/b978-0-323-85455-9.00001-1

Cited by 4 publications

(4 citation statements)

References 152 publications

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“…Moreover, their insensitivity towards any change in pH, temperature, and ionic strength make them a preferred choice over antibodies. In the year 1996, fluorescently labelled aptamer was first reported to be utilized as a bio-detection agent in biosensors [ 42 , 43 , 44 , 45 ]. In the last decade, the implementation of aptamers has increased exponentially in the design of biosensors.…”

Section: Label and Label-free Aptasensorsmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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Viral infections are becoming the foremost driver of morbidity, mortality and economic loss all around the world. Treatment for diseases associated to some deadly viruses are challenging tasks, due to lack of infrastructure, finance and availability of rapid, accurate and easy-to-use detection methods or devices. The emergence of biosensors has proven to be a success in the field of diagnosis to overcome the challenges associated with traditional methods. Furthermore, the incorporation of aptamers as bio-recognition elements in the design of biosensors has paved a way towards rapid, cost-effective, and specific detection devices which are insensitive to changes in the environment. In the last decade, aptamers have emerged to be suitable and efficient biorecognition elements for the detection of different kinds of analytes, such as metal ions, small and macro molecules, and even cells. The signal generation in the detection process depends on different parameters; one such parameter is whether the labelled molecule is incorporated or not for monitoring the sensing process. Based on the labelling, biosensors are classified as label or label-free; both have their significant advantages and disadvantages. Here, we have primarily reviewed the advantages for using aptamers in the transduction system of sensing devices. Furthermore, the labelled and label-free opto-electrochemical aptasensors for the detection of various kinds of viruses have been discussed. Moreover, numerous globally developed aptasensors for the sensing of different types of viruses have been illustrated and explained in tabulated form.

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Section: Label and Label-free Aptasensorsmentioning

confidence: 99%

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

et al. 2022

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“…Purohit et al, 2020b). Biosensors are used in almost every field (Azad et al, 2022;Mahato et al, 2018b), and one such is detecting health-deteriorating carcinogenic metals. According to reports, most heavy metals can potentially cause cancer and are carcinogenic.…”

Section: Introductionmentioning

confidence: 99%

Bioengineered Platforms for Detection Of Group-1 Carcinogenic Metals

Singh

2024

Preprint

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Studies at the molecular, systemic, and epidemiological levels have shown that chronic metal exposure is linked to significant health consequences, including cancer, affecting hundreds of millions worldwide. Subtle and convoluted mechanisms underline metals' toxicity and carcinogenicity. The use of sensors for carcinogenic metals' trace detection is on the rise due to their selectivity, simplicity, and affordability. Biotechnology and microelectronics in the development of sensors have grown complementarily in recent years. This study offers a comprehensive overview of current research and advancements in developing sensors for detecting carcinogenic metals. Here, we have focussed on the developed biosensor platforms for group 1 carcinogens, i.e., arsenic, nickel, cadmium, chromium, and beryllium, along with their brief roles in human carcinogenesis. This review also looks at the importance of sensing such metal exposure in humans from a larger perspective, hoping to influence future research toward early prevention and treatment of illnesses like cancer.

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“…Due to the strong electronegativity of nitro group, they are harmful to the environment. If the nitro compounds are directly discharged into the water bodies, they can pollute the water and cause carcinogenesis in the human body upon high exposure [3]. Nitrofurantoin (NFT), an antimicrobial drug, is active against the Grampositive and Gram-negative microbes [4,5].…”

Section: Introductionmentioning

confidence: 99%

Graphene Nanoribbons/Manganese Oxide Nanocomposite Modified Electrode for Detection of Antimicrobial Drug Nitrofurantoin

Nagarajan¹,

Magesh

Sundramoorthy

et al. 2023

Journal of Nanomaterials

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The design and development of a new kind of cost-effective electrode material with excellent selectivity and stability are still a great challenge in the field of electrochemical sensors. Recently, researchers have paid more attention to the electrochemical reduction of nitro compounds due to their hazardous nature. Nitro compounds play a vital role in various industrial applications. However, the direct discharge of nitro compounds to the environment as industrial wastewater is harmful. In this study, a nanocomposite made of 1D graphene nanoribbons decorated with manganese dioxide (GNR-MnO2) was prepared to fabricate an electrochemical transducer for the determination of nitrofurantoin (NFT) in biofluids. First, 1D GNR was prepared by unzipping of multiwalled carbon nanotubes. Second, the GNR was decorated with MnO2 by the hydrothermal reduction method. As-prepared GNR-MnO2 nanocomposite was comprehensively characterized by field emission scanning electron microscopy with EDX, XRD, UV–visible, electrochemical impedance spectroscopy, and cyclic voltammetry. Moreover, GNR-MnO2-coated glassy carbon electrode (GCE) exhibited good electrocatalytic activity toward NFT. The electroreduction of NFT was found at −0.40 V which was 50 mV lower than bare GCE. GNR-MnO2 nanocomposite modified GCE showed a well-defined linear reduction peak current for NFT from 10 nM to 1,000 µM. The selectivity of the sensor was also analyzed in the presence of other nitro compounds which confirmed that NFT can be selectively detected at −0.4 V. The GNR-MnO2 modified electrode was also able to separate reduction peaks of other nitro compounds. In addition, the detection of NFT was carried out in human urine samples with a good recovery of 99.60%–98.60%.

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Electrochemical biosensors for monitoring of bioorganic and inorganic chemical pollutants in biological and environmental matrices

Cited by 4 publications

References 152 publications

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems

Bioengineered Platforms for Detection Of Group-1 Carcinogenic Metals

Graphene Nanoribbons/Manganese Oxide Nanocomposite Modified Electrode for Detection of Antimicrobial Drug Nitrofurantoin

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