Electrochemical biosensors for hormone analyses

Bahadır, Elif; Sezgintürk, Mustafa Kemal

doi:10.1016/j.bios.2014.12.054

Cited by 139 publications

(68 citation statements)

References 62 publications

(55 reference statements)

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“…Hormones, which are the signaling molecules secreted from glands, play an important role in the regulation of human physiological activities . Among them, multiple steroid hormones (including androgens, estrogens, and progestogens) exhibit synergistic effects on the body for its development, growth, and functions .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Visualization and Quantitation of Multiple Steroid Hormones Based on Signal‐Amplified Biosensing with Duplex Molecular Recognition

Tan

et al. 2017

Chemistry A European J

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The simultaneous quantitation of multiple steroid hormones in real time is of great importance in medical diagnosis. In this study, a portable hormone biosensor based on duplex molecular recognition coupled with a signal-amplified substrate was successfully developed for the simultaneous visualization and quantitation of multiple steroid hormones. Aptamer-functionalized upconversion nanoparticles (UCNPs) with different emission peaks are immobilized on the photonic crystal (PC) substrate as the nanoprobes, leading to the specific and simultaneous assay of multiple steroid hormones. Coupled with the luminescence-enhanced effect of the PC substrate, nanomolar quantification limits of multiple hormones are achieved. This well-designed biosensor is also promising in the quantification of multiple hormones in serum samples. The amplified luminescence signals can be visualized with the naked eye and captured by an unmodified phone camera. This hormone quantitation biosensor exhibits the advantages of multi-detection, visualization, high sensitivity, and selectivity for potential applications in clinical disease diagnosis.

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Section: Introductionmentioning

confidence: 99%

Simultaneous Visualization and Quantitation of Multiple Steroid Hormones Based on Signal‐Amplified Biosensing with Duplex Molecular Recognition

Tan

et al. 2017

Chemistry A European J

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“…5 Few studies have explored the chain-length effect of SAM on the sensing properties of impedimetric immunosensors. EIS was used to estimate the immunosensors with different modifying steps via MPA, MUA and MHA SAM, as shown in Fig.…”

Section: Effect Of Chain Length Of Modified Layermentioning

confidence: 99%

Effect of the Chain Length of a Modified Layer and Surface Roughness of an Electrode on Impedimetric Immunosensors

Lin

2017

ANAL. SCI.

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An ultrasensitive label-free impedimetric immunosensor is constructed by modifying a 3-mercaptoproponic acid (MPA) monolayer on highly rough gold nanostructure (AuNS)-electrodeposited screen printed carbon electrodes (SPCEs) for the detection of small molecular weight drugs (SMWDs), such as salbutamol (SAL). The SPCEs preoxidized in a 0.1 M H2SO4 solution (called po-SPCEH2SO4) are electrodeposited with the AuNS to increase the roughness factor to 23.64 ± 1.76, larger than the AuNS/po-SPCENaOH or the AuNS/po-SPCEPBS. Furthermore, the MPA modified layer as a link for the anti-SAL immobilization to give the immunosensors an impedimetric signal-to-noise ratio larger than the 11-mercaptoundecanoic acid-and 16-mercaptohexadecanoic acid-modified layer, due to the lower interfacial impedance of the MPA monolayer. The MPA/AuNS/po-SPCEH2SO4-based immunosensors have a wide linear range of 1 fg mL -1 to 1 ng mL -1 and a limit of detection of 0.6 fg mL -1 . Moreover, the immunosensors can practically quantify the SAL concentrations in 1000 times-diluted serum samples with good recovery.

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“…An electrochemical sensor is a device that provides an electrochemical response in the presence of an analyte such as amperometric, potentiometric, conductometric or impedimetric responses, which can be, thus, detected by electrochemical techniques [52]. Electrochemical biosensors consist of electrochemical sensors that use a biomolecule in its conception, either as recognition element or as transducer.…”

Section: Supramolecular Compounds For Electrochemical Biosensorsmentioning

confidence: 99%

Supramolecular Materials for Optical and Electrochemical Biosensors

Martins¹,

Ribeiro²,

FlavioColmati³

et al. 2015

Biosensors - Micro and Nanoscale Applications

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It is incontestable that the interactions and bonds that keep molecules united to generate unique supramolecular compounds, with individual properties, morphologies and behaviour, are of special dynamics and singular forces. Therefore, it is necessary to discuss and consider the types of interactions that may occur in a determined system, their dynamics and number, which directly act on the energetic balance that strengthen the union between participants and give rise to a supramolecule.In this chapter, a number of such supramolecular systems that find application as any component of a biosensor are presented and discussed, considering intermolecular interaction forces that confer them shape, function and unique properties. To better understand their structural dynamics and the mechanisms through which they can be used in biosensing, a brief explanation on the interaction thermodynamics, types of intermolecular interactions that compete against each other and the energetic equilibrium that originate and stabilize supramolecular systems is given. To explain how this balance of forces can be extensively exploited to develop methods to produce supramolecular compounds, an overview on supramolecular strategies is presented and their contribution is explored in each example presented in this text, to evidence the importance of planning and developing methodologies of preparation, based on

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Electrochemical biosensors for hormone analyses

Cited by 139 publications

References 62 publications

Simultaneous Visualization and Quantitation of Multiple Steroid Hormones Based on Signal‐Amplified Biosensing with Duplex Molecular Recognition

Simultaneous Visualization and Quantitation of Multiple Steroid Hormones Based on Signal‐Amplified Biosensing with Duplex Molecular Recognition

Effect of the Chain Length of a Modified Layer and Surface Roughness of an Electrode on Impedimetric Immunosensors

Supramolecular Materials for Optical and Electrochemical Biosensors

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