Electrochemical biosensors based on nanofibres for cardiac biomarker detection: A comprehensive review

Rezaei, Babak; Ghani, Mozhdeh; Shoushtari, Ahmad Mousavi; Rabiee, Mohammad

doi:10.1016/j.bios.2015.11.083

Cited by 98 publications

(49 citation statements)

References 115 publications

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“…made a cell capture assay based on anti‐EpCAM grafted electrospun TiO 2 nanofibers in order to circulate tumor cells detection in colorectal and gastric cancer patients, which significantly enhanced the capture efficiency. Rezaei et al . summarized researches about the diagnosis of CVDs via nanofiber‐based electrochemical biosensors .…”

Section: Biosensors and Health Monitoring Systemmentioning

confidence: 99%

“…Rezaei et al . summarized researches about the diagnosis of CVDs via nanofiber‐based electrochemical biosensors . Miyamoto and co‐workers developed highly gas‐permeable, inflammation‐free, lightweight, and stretchable nanofiber sensors that can be directly laminated onto human skin for long periods of time.…”

Section: Biosensors and Health Monitoring Systemmentioning

confidence: 99%

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Nanofibers for Biomedical and Healthcare Applications

Rasouli

Barhoum

Bechelany

et al. 2018

Macromolecular Bioscience

216

112

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Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrication techniques (i.e., physical, chemical, and biological methods), and emerging applications in biomedical and healthcare fields. It summarizes the recent researches on nanofibers for drug delivery systems and controlled drug release, tissue‐engineered scaffolds, dressings for wound healing, biosensors, biomedical devices, medical implants, skin care, as well as air, water, and blood purification systems. Attention is given to different types of fibers (e.g., mesoporous, hollow, core‐shell nanofibers) fabricated from various materials and their potential biomedical applications.

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Section: Biosensors and Health Monitoring Systemmentioning

confidence: 99%

Section: Biosensors and Health Monitoring Systemmentioning

confidence: 99%

Nanofibers for Biomedical and Healthcare Applications

Rasouli

Barhoum

Bechelany

et al. 2018

Macromolecular Bioscience

216

112

View full text Add to dashboard Cite

show abstract

“…Different chemical functionalizations such as −COOH, −OH, −SH or −NH 2 [10–11] have been considered into CNTs applications. Carboxylated single‐wall carbon nanotubes (SWCNTs‐COOH) with inherently large surface‐area‐to‐volume ratios, which provide excellent places for biological molecule attachment and improve the loading capacities of these molecules over conventional material . After sulfhydrylation, the obtained SWCNTs‐SH nanomaterial not only retained all the excellent properties of SWCNTs‐COOH, and at the same time thiolated SWCNTs seems to be a good option for working with gold electrodes and gold nanoparticles due to the affinity gold‐sulphur .…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanomaterials‐based Electrochemical Immunoassay with β‐Galactosidase as Labels for Carcinoembryonic Antigen

Jin

Lou

et al. 2018

Electroanalysis

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In this study, a novel signal‐amplified strategy for sensitive electrochemical sandwiched immunoassay of carcinoembryonic antigen (CEA) was constructed based on aminofunctionalized graphene oxide (GO‐NH2) supported AgNPs used as catalytic labels of secondary anti‐CEA and β‐galactosidase (β‐Gal), Meanwhile, sulfhydrylation single‐wall carbon nanotubes (SWCNTs‐SH) as substrate materials embellished gold electrode through Au‐SH and connected with gold nanoparticles to form anti‐CEA/AuNPs/SWCNTs‐SH/Au sensing platform through layer‐by‐layer. In the presence of analyte CEA, a sandwich‐type immunoassay format was employed for determination of CEA by using the labeled β‐Gal toward the reduction of p‐aminophenyl galactopyranoside (PAPG) and the redox reaction of AgNPs. Under optimal conditions, the increase in the current was proportional to the concentration of CEA from 0.1 pg/mL to 200 ng/mL. The detection limit (LOD) was 0.036 pg/mL CEA at 3σ. The electrochemical immunoassay displayed an acceptable precision, selectivity, stability. Clinical serum specimens were assayed with the method, and the results were in acceptable agreement with those obtained from the referenced electrochemiluminescent method.

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“…Electrochemical immunosensors are notable analytical devices for the diagnosis of diseases, such as AMI, especially because of their rapid response, relatively low cost, portability and high specificity and selectivity ,,,. In the last decade, immunosensors have been hugely influenced by progress in nanotechnology, enabling the development of novel and unique detection platforms for disease diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…In the last decade, immunosensors have been hugely influenced by progress in nanotechnology, enabling the development of novel and unique detection platforms for disease diagnosis. Nanomaterials (e. g. nanoparticles, nanotubes, nanowires, nanofibers and nanocomposites) have provided a means to increase the surface area for the immobilization and sensing of biomolecules, enhancing the catalytic properties of the electrodes and providing highly sensitive biosensors ,,.…”

Section: Introductionmentioning

confidence: 99%

Label‐free Electrochemical Immunosensor for Cardiac Troponin T Based on Exfoliated Graphite Nanoplatelets Decorated with Gold Nanoparticles

et al. 2017

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This paper describes the application of exfoliated graphite nanoplatelets (xGnP) decorated with gold nanoparticles (AuNP) for the development of a label‐free electrochemical immunosensor for the determination of human cardiac troponin T (TnT), an important cardiac biomarker in the diagnosis of acute myocardial infarction (AMI). Heparin‐stabilized AuNP (AuNP‐Hep) were synthesized, characterized and supported on xGnP. The material obtained (AuNP‐Hep‐xGnP) was used as a platform to immobilize the anti‐TnT by adsorption and this was then applied in the construction of an immunosensor. Under optimized conditions, using differential pulse voltammetry (DPV) and an incubation time of 20 min, the proposed immunosensor showed linearity in the range of 0.050 to 0.35 ng mL−1 TnT, with a calculated limit of detection of 0.016 ng mL−1. The interday precision (n=7) showed a coefficient of variation of 6.5 %. Some potential interferents commonly present in blood plasma samples were investigated and the degree of interference was found to be low (less than 10 %), demonstrating adequate selectivity for analytical applications. The biosensor was successfully applied in the determination of TnT in fortified samples of human blood plasma.

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Electrochemical biosensors based on nanofibres for cardiac biomarker detection: A comprehensive review

Cited by 98 publications

References 115 publications

Nanofibers for Biomedical and Healthcare Applications

Nanofibers for Biomedical and Healthcare Applications

Carbon Nanomaterials‐based Electrochemical Immunoassay with β‐Galactosidase as Labels for Carcinoembryonic Antigen

Label‐free Electrochemical Immunosensor for Cardiac Troponin T Based on Exfoliated Graphite Nanoplatelets Decorated with Gold Nanoparticles

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