Electrochemical biosensing to move forward in cancer epigenetics and metastasis: A review

Campuzano, Susana; Barderas, Rodrigo; Pedrero, Marı́a; Yáñez‐Sedeño, Paloma; Pingarrón, José M.

doi:10.1016/j.aca.2020.01.047

Cited by 19 publications

(9 citation statements)

References 120 publications

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“…They have exceptional throughput and accuracy for the direct detection of tumor cells in body fluid samples. 34 Electrochemical detection of numerous liquid biopsies for cancer has been the topic of discussion in a number of very good reviews; however, the majority of these studies mostly focused on single LB such as proteins, miRNA, ctDNA, exosomes, and cancer cells. 30,[35][36][37][38] A comprehensive review wrapping up the current magnificent state of the art in pointof-care (POC) and biosensor technology for all LB markers is currently awaiting publication in a single report.…”

Section: Introductionmentioning

confidence: 99%

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Tailored point-of-care biosensors for liquid biopsy in the field of oncology

et al. 2023

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Section: Introductionmentioning

confidence: 99%

“…They have exceptional throughput and accuracy for the direct detection of tumor cells in body fluid samples. 34…”

Section: Introductionmentioning

confidence: 99%

Tailored point-of-care biosensors for liquid biopsy in the field of oncology

et al. 2023

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“…Diagnostic efforts to interrogate intracellular properties at a single-cell level traditionally require the extraction of intracellular materials like genetic material [ 1 , 2 , 3 ] or extracellular vesicles [ 4 , 5 , 6 ]. Other methods introduce stains for the purpose of identifying intracellular characteristics through fluorescence imaging or flow cytometry [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Single-Cell Classification Based on Population Nucleus Size Combining Microwave Impedance Spectroscopy and Machine Learning

Ferguson

Hwang

Cheng

2023

Sensors

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Many recent efforts in the diagnostic field address the accessibility of cancer diagnosis. Typical histological staining methods identify cancer cells visually by a larger nucleus with more condensed chromatin. Machine learning (ML) has been incorporated into image analysis for improving this process. Recently, impedance spectrometers have been shown to generate all-inclusive lab-on-a-chip platforms to detect nucleus abnormities. In this paper, a wideband electrical sensor and data analysis paradigm that can identify nuclear changes shows the realization of a single-cell microfluidic device to detect nuclei of altered sizes. To model cells of altered nucleus, Jurkat cells were treated to enlarge or shrink their nucleus followed by broadband sensing to obtain the S-parameters of single cells. The ability to deduce important frequencies associated with nucleus size is demonstrated and used to improve classification models in both binary and multiclass scenarios, despite a heterogeneous and overlapping cell population. The important frequency features match those predicted in a double-shell circuit model published in prior work, demonstrating a coherent new analytical technique for electrical data analysis. The electrical sensing platform assisted by ML with impressive accuracy of cell classification looks forward to a label-free and flexible approach to cancer diagnosis.

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“…For more information on electrochemical biosensors developed for cancer diagnosis, both containing types of graphene and with other nanomaterial design contents, some valuable review studies reported recently are available in the literature [ 18 , 75 , 77 , 90 , 128 , 129 , 130 , 131 , 132 ].…”

Section: Introductionmentioning

confidence: 99%

Current Perspectives in Graphene Oxide-Based Electrochemical Biosensors for Cancer Diagnostics

Ozkan-Ariksoysal

2022

Biosensors

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Since the first commercial biosensor device for blood glucose measurement was introduced in the 1970s, many “biosensor types” have been developed, and this research area remains popular worldwide. In parallel with some global biosensor research reports published in the last decade, including a great deal of literature and industry statistics, it is predicted that biosensor design technologies, including handheld or wearable devices, will be preferred and highly valuable in many areas in the near future. Biosensors using nanoparticles still maintain their very important place in science and technology and are the subject of innovative research projects. Among the nanomaterials, carbon-based ones are considered to be one of the most valuable nanoparticles, especially in the field of electrochemical biosensors. In this context, graphene oxide, which has been used in recent years to increase the electrochemical analysis performance in biosensor designs, has been the subject of this review. In fact, graphene is already foreseen not only for biosensors but also as the nanomaterial of the future in many fields and is therefore drawing research attention. In this review, recent and prominent developments in biosensor technologies using graphene oxide (GO)-based nanomaterials in the field of cancer diagnosis are briefly summarized.

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Electrochemical biosensing to move forward in cancer epigenetics and metastasis: A review

Cited by 19 publications

References 120 publications

Tailored point-of-care biosensors for liquid biopsy in the field of oncology

Tailored point-of-care biosensors for liquid biopsy in the field of oncology

Single-Cell Classification Based on Population Nucleus Size Combining Microwave Impedance Spectroscopy and Machine Learning

Current Perspectives in Graphene Oxide-Based Electrochemical Biosensors for Cancer Diagnostics

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