Electrochemical behaviors of diethylstilbestrol and its application in pharmacokinetics

Qiu, Bin; Wang, Wei; Chi, Yuwu

doi:10.1016/j.ab.2004.09.028

Cited by 20 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By comparison, conventional electrochemical techniques are less expensive and have additional advantages of high sensitivity, simple operation and easy miniaturization [16]. In the past decade, electrochemical detection of DES has been reported from time to time using working electrodes based on carbon or platinum [17][18][19][20][21][22]. However, the detection sensitivity still needs to be improved considering the low concentration of DES.…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide-modified electrodes for sensitive determination of diethylstilbestrol

Yu¹,

Wan-yu²,

Wang³

et al. 2013

Nanotechnology

View full text Add to dashboard Cite

This paper reports an electrochemical sensor fabricated with graphene oxide (GO) modified on a chitosan-coated glassy carbon electrode (GO-CS/GCE) and its application for the detection of diethylstilbestrol (DES). It was observed that the effective electrochemical surface area of the GO modified electrode was nearly 10 times that of the bare GCE. This could be used to explain the results that the oxidation peak current of DES on the GO-CS/GCE was much larger than on the bare GCE. Under optimized conditions, the prepared electrode could be used to electrochemically detect DES according to the oxidation of the DES. Based on the technique of differential pulse voltammetry and the accumulation of DES on GO modified electrodes, the calibration curve for DES determination could be obtained with a linear range of 1.5 × 10(-8)-3.0 × 10(-5) M and an estimated detection limit of 3.0 × 10(-9) M (S/N = 3). The feasibility of the developed electrode for tablet sample analysis was investigated. Our investigation revealed that GO could significantly improve the analytical performance of electrochemical sensors.

show abstract

Section: Introductionmentioning

confidence: 99%

Graphene oxide-modified electrodes for sensitive determination of diethylstilbestrol

Yu¹,

Wan-yu²,

Wang³

et al. 2013

Nanotechnology

View full text Add to dashboard Cite

show abstract

“…High-performance liquid chromatography (HPLC) [5,6], chemiluminescence [7] are conventionally used for performing ultra-trace level analysis of DES, but these analytical methods are not very suitable for rapidly screening in food samples [8][9][10][11]. Electrochemical enzyme-linked immunoassay (ECI) is a highly sensitive technique that exhibits enhanced electrochemical catalytic ability.…”

Section: Introductionmentioning

confidence: 99%

A novel sandwich-type noncompetitive immunoassay of diethylstilbestrol using β-cyclodextrin modified electrode and polymer–enzyme labels

Yan

Xiong

Gan

et al. 2015

Journal of Electroanalytical Chemistry

View full text Add to dashboard Cite

“…However,t he worldwide reports about illegal use of DES in animal production remind us that the residue of DES in food is still ar eal threat to human health. [13] To control its abuse, various methods, including chromatographic techniques, [14] enzyme-linked immunosorbent assays (ELISAs), [15] ande lectrochemical analyses, [16] have been developedf or the detection of DES. Nevertheless, these methods intrinsically suffer from the drawbacks of needinge quipment,t ime, strict pretreatment, and susceptibility to matrix effects.…”

Section: Introductionmentioning

confidence: 99%

Enzyme‐Assisted Metal–Organic Framework Sensing System for Diethylstilbestrol Detection

Chang

et al. 2017

Chemistry A European J

View full text Add to dashboard Cite

As novel fluorescent-sensing materials, metal-organic frameworks (MOFs) have shown great potential in environmental monitoring. However, most of the researches are limited to traditional pollutants, whereas the application of MOFs to the detection of the pollutants with more complicated structures, such as endocrine disrupting chemicals (EDCs), has rarely been explored. The difficulties faced in the sensing of EDCs include their electronic stability and the structural similarity among homologues, which could be overcome by the incorporation of enzymatic reaction. In this work, the first example of enzyme-assisted MOF-fluorescent-sensing was developed for the analysis of diethylstilbestrol (DES, a synthetic estrogen). In this system, DES is first oxidized by HRP/H O quantitatively to its quinone form, and then the quinone product is selectively captured by a stilbene based luminescent MOF to induce fluorescence response. By the tandem sensitization and filtration of enzymatic reaction and MOF adsorption, this method shows high sensitivity (DL=89 nm) and can distinguish DES from other similar-structured EDCs.

show abstract

Electrochemical behaviors of diethylstilbestrol and its application in pharmacokinetics

Cited by 20 publications

References 9 publications

Graphene oxide-modified electrodes for sensitive determination of diethylstilbestrol

Graphene oxide-modified electrodes for sensitive determination of diethylstilbestrol

A novel sandwich-type noncompetitive immunoassay of diethylstilbestrol using β-cyclodextrin modified electrode and polymer–enzyme labels

Enzyme‐Assisted Metal–Organic Framework Sensing System for Diethylstilbestrol Detection

Contact Info

Product

Resources

About