Electrochemical behavior of the antituberculosis drug isoniazid and its square-wave adsorptive stripping voltammetric estimation in bulk form, tablets and biological fluids at a mercury electrode

Ghoneim, Mohammed M.; El-Baradie, Kamal Y.; Tawfik, A

doi:10.1016/s0731-7085(03)00311-x

Cited by 59 publications

(20 citation statements)

References 39 publications

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“…Tong et al (1997) described the voltammetric determination of isoniazid on vitreous carbon electrode. Ghoneim et al (2003) reported the utilization of a procedure of voltammetry of adsorptive redissolution, employing a mercury electrode for the determination of isoniazid in pharmaceutical formulations and in biologic fluids. Wahdan (2005) and Liang et al (2007) studied the voltammetric behavior of rifampicin oxidation, reporting that the mechanism involves the same typical number of electrons and protons as for hydroquinones.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Leandro

Carvalho

Giovanelli

et al. 2009

Braz. J. Pharm. Sci.

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Tuberculosis remains a major public health problem, especially in developing countries. Brazil presents the largest number of cases in Latin America and is among the 22 countries considered priorities by the World Health Organization (WHO). The Rio de Janeiro state has the largest number of cases registered in the country. The treatment of patients, commonly, makes use of the drugs isoniazid and rifampicin for six months. This study aimed to develop and validate an electroanalytical methodology, using the technique of differential pulse voltammetry for the determination of these drugs in the associated form, in order to evaluate the quality of medicines distributed in the state of Rio de Janeiro. The potential reduction for the isoniazid and rifampicin were -1.10 and -0.90 V. The developed and validated electroanalytical method presented a linear range of 0.25 to 1.25 mg/L to isoniazid, limits of detection and quantification of 0.05 and 0.14 mg/L, and recovery of 98.2 ± 0.4%; a tracking linear of 0.40 to 2.00 mg/L for rifampicin, with limits of detection and quantification of 0.07 and 0.19 mg/L and recovery of 95.8 ± 0.6%. Six lots of medicines from two pharmaceutical companies were analyzed. Only one of the samples showed unsatisfactory levels of rifampicin.Uniterms: Isoniazid. Rifampicin. Tuberculosis/treatment. Tuberculostatics/quantitative analysis. Differential pulse voltammetry.A tuberculose continua sendo um importante problema de saúde pública, especialmente em países em desenvolvimento. O Brasil apresenta o maior número de casos da América Latina, estando entre os 22 países considerados prioritários nas ações de controle da doença pela Organização Mundial da Saúde (OMS). No Brasil, o Rio de Janeiro é o estado com o maior número de casos registrados no país. O tratamento de doentes com tuberculose faz uso dos fármacos isoniazida e rifampicina durante seis meses. O presente trabalho objetivou desenvolver e validar metodologia eletroanalítica, utilizando a técnica de voltametria de pulso diferencial, para a determinação desses dois princípios ativos na forma associada e avaliar a qualidade dos medicamentos distribuídos no estado do Rio de Janeiro. Os potenciais de redução para a isoniazida e rifampicina foram respectivamente -1,10 e -0,90 V. O método eletroanalítico desenvolvido e validado apresentou para a isoniazida faixa linear de 0,25 a 1,25 mg/L, limites de detecção e quantificação de 0,05 e 0,14 mg/L e recuperação de 98,2 ± 0,4%; para a rifampicina faixa linear de 0,40 a 2,00 mg/L, limites de detecção e quantificação de 0,07 e 0,19 mg/L e recuperação de 95,8 ± 0,6%. Foram analisados 6 lotes de medicamentos de dois laboratórios farmacêuticos. Apenas uma das amostras apresentou teor de rifampicina insatisfatório.Unitermos: Isoniazida/determinação. Rifampicina/determinação. Tuberculostáticos/análise quantitativa. Tuberculose/tratamento. Voltametria de pulso diferencial/utilização.

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Section: Introductionmentioning

confidence: 99%

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Leandro

Carvalho

Giovanelli

et al. 2009

Braz. J. Pharm. Sci.

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“…In case of electroanalysis used are stripping methods such as potentiometry [38,39], polarography [40,41], differential-pulse polarography [42,43] and stripping voltammetry [44][45][46][47][48][49]. The HMDE is the electrode of preference due to its high sensitivity, reproducibility and linearity.…”

Section: Introductionmentioning

confidence: 99%

Voltammetric Determination of Isoniazid using Cyclic Renewable Mercury Film Silver Based Electrode

2012

Pharm Anal Acta

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A new cathodic voltammetry method for the determination of isoniazid based on the cyclic renewable mercury film silver based electrode (Hg (Ag) FE) is presented. The effects of various factors such as: preconcentration potential and time, pulse height, step potential and supporting electrolyte composition are optimized. The calibration graph is linear from 5 nM up to 500 nM (68.55 µgL -1 ). For Hg (Ag) FE with a surface area of 9.7 mm 2 without time consuming preconcentration the limits of detection LOD and quantification LOQ were 4.1 nM and 10.5 nM of isoniazid, respectively. The repeatability of the method at a concentration level of the analyte as low as 0.5 nM, expressed as RSD is 3.6% (n=6). The proposed method was successfully applied in analysis of isonizid in simple and composed pharmaceutical formulations.

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“…The electroanalytical methods described in literature for INZ determination in pharmaceutical formulations and human serum have demonstrated success [11][12][13][14][15][16][17][18]. The polarographic reduction of isoniazid drug has been studied by Ghoneim et al [15] using a square-wave adsorptive cathodic stripping procedure. The polarographic behavior is different in acidic and alkaline solutions.…”

Section: Introductionmentioning

confidence: 99%

Determination of isoniazid in human urine using screen-printed carbon electrode modified with poly-l-histidine

Bergamini

Santos

Zanoni

2010

Bioelectrochemistry

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Electrochemical behavior of the antituberculosis drug isoniazid and its square-wave adsorptive stripping voltammetric estimation in bulk form, tablets and biological fluids at a mercury electrode

Cited by 59 publications

References 39 publications

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Development and validation of an electroanalytical methodology for determination of isoniazid and rifampicin content in pharmaceutical formulations

Voltammetric Determination of Isoniazid using Cyclic Renewable Mercury Film Silver Based Electrode

Determination of isoniazid in human urine using screen-printed carbon electrode modified with poly-l-histidine

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