Electrochemical behavior of nitrofurantoin and assay of its formulations

Abstract

ABSTmCTThe electrochemical behavior of nitrofurantoin was studied by employing dc polarography, cyclic voltammetry, and differential pulse polarography in universal buffers of pH 2.0-12.0. Kinetic parameters such as transfer coefficients, diffusion coefficients, and heterogeneous forward rate constant values were evaluated using these techniques. Differential pulse polarography was employed for the estimation of this drug in several pharmaceutical formulations.

Voltammetric Determination of Nitrofurantoin at a Mercury Meniscus Modified Silver Solid Amalgam Electrode

“…The electrochemical behavior of these compounds has been examined using boron-doped diamond electrodes [31], activated carbon fiber microelectrodes [32], or hanging galinstan drop electrode [33]. Several polarographic or voltammetric methods at mercury electrodes have been published as well [34][35][36][37][38][39].…”

“…Moreover, all biological activity of the nitrocompounds depends on the reduction of the nitro group, as was already said in the introduction, and, thus, we have focused our attention on peaks I and II. Electrochemical behavior of NF at mercury electrodes is described in several papers [3,35,36,39] which can give certain clue to interpretation of peaks III and IV.…”

Cucurbit[7]uril-stabilized gold nanoparticles as catalysts of the nitro compound reduction reaction

“…The EU and FDA banned the use of NF due to the toxicity, carcinogenic and mutagenic potency of the nitrofurans and their metabolites although they are still used in some countries. [23][24][25][26] The aquatic photochemistry of NF was investigated in environmentally relevant conditions 27 and in acid and basic aqueous medium subjected to thermal and photodegradation. 28 On the other hand, the action as catalyst of different biological reductases (i.e., cytochrome P450 reductase and nitro-reductases) in the reductive NF reaction by NAD(P)H has been investigated.…”

“…Although these works are focused on the electroanalytical determination of the target compound, the discussion of the reduction mechanism is included. 25,26 However, the catalytic performance of metal nanosystems has been usually evaluated in the nitrophenols (4-nitrophenol, 4-NP) reduction reaction. So, to make a comparison with recently published works in which relatively good catalytic performances were reported, this reaction was also studied and the comparison with CB7stabilized AuNPs is reported herein for the rst time.…”

Electrochemical Behaviors and Determinations of Some 2,5-Disubstituted Benzoxazole Compounds at the Hanging Mercury Drop Electrode

“…Numerous nitro-bearing drugs have been studied from electrochemical point of view [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. In cases where the compounds involved were water-soluble mixed solvents [13,15,16,[24][25][26][27], dimethylformamide (DMF) [15,[24][25][26] and dimethylsulfoxide (DMSO) [12,14,17,18,24] were used as the reaction media.…”