Electrochemical Behavior and Ultrasensitive, Simple and Effective Voltammetric Determination of Acetaminophen Using Modified Glassy Carbon Electrode Based on 4‐Hydroxyquinoline‐3‐carboxylic Acid

Abstract

An electrochemical oxidation of acetaminophen (ACOP) has been successfully performed by using glassy carbon electrode covered with 4-hydroxyquinoline-3carboxylic acid (4HQ3CA) to reinforce electrode's feature. To characterize the modified electrode (4HQ3CA/ GC), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and Fourier transform infrared spectroscopy (FT-IR) techniques were used. The finding optimum conditions (supporting electrolyte, pH) and the electrochemical determination studies were performed with differential pulse voltammetry (DPV). It was decided that the supporting electrolyte medium suitable for ACOP determination was Britton-Robinson (BR) buffer and the effect of pH change on the oxidation peak of ACOP in this media was investigated. The effect of changing scan rate on the oxidation peak of ACOP was examined and this study showed that the oxidation process of ACOP on the 4HQ3CA/GC modified electrode surface was diffusion and adsorption controlled process. A wide concentration range from 0.0025 μM to 141 μM with a limit of detection (LOD) of 5.98 × 10 À 10 M (3 s/m) was obtained. This prepared sensor was carried out for the determination of ACOP in pharmaceutical sample.

Synthesis of Zinc Oxide Nanoparticles Based on Coffee Husks Embedded on Mesoporous Silica for the Sensing of Acetaminophen

“…Then the plot of peak potential in function of pH (Figure 7B-2) give a linear equation with the slop of À 0.045 V, which is closed to the Nernst value (0.059 V), suggesting an equal change of protons and electrons during the oxidation of ACT. [63,64] On the basis of this result, the possible oxidation mechanism for the oxidation of ACT is proposed by the reaction 1.…”