Electrochemical behavior and assay of anti-Parkinson drug selegiline using cathodic adsorptive stripping square wave voltammetry in bulk form

Abstract

Abstract:The electrochemical reduction behavior of selegiline was investigated by cyclic voltammetry using glassy carbon electrode and validated by square wave cathodic adsorptive stripping voltammetry. Selegiline gave one well-defined reduction peak in the potential range −0.4 to −0.5 V versus Ag/AgCl electrode. The reduction process is irreversible and partial diffusion controlled. Various chemical and instrumental parameters affecting the electroanalytical response for the determination of selegiline were investigated and optimized. Under optimized conditions, the adsorptive stripping peak current is found to be linear over the concentration range of 3.0×10 −7 -2.5×10−5 M with a detection limit of 3.04×10 −8 M and a lower limit of quantification of 1.01×10 −7 M.

Electrochemical Behaviour and Adsorptive Stripping Voltammetric Determination of Cyclophosphamide

“…Detection limit was calculated as LOD = 3 S/m and limit of quantification was calculated using equation LOQ= 10 S/m where, s is the standard deviation of intercept of calibration curve and m is the slope of the related calibration curve [24][25][26] . Low values of detection and quantification limits indicated about the good sensitivity of the proposed method.…”

Adsorptive Stripping Voltammetric Determination of Bupropion in Pharmaceuticals

“…The LOD is the smallest concentration or amount that can be detected with reasonable certainty for a given analytical procedure All the analytical data are shown in the Table 1. The detection limit was calculated by the equation [36][37][38] .…”

Electrochemical Determination of Letrozole in Pharmaceutical Formulations by Advanced Voltammetric Techniques

“…The LOD is the smallest concentration or amount that can be detected with reasonable certainty for a given analytical procedure. The detection limit was calculated by the equation 28,29 LOD= 3SD/b, Where SD is the standard deviation of the peak currents (five runs) and b is the slope of the calibration curve. The calculated detection limit for the standard solution was 3.89x10 …”