Electrochemical aptamer biosensor for As<sup>3+</sup>based on apta deep trapped Ag-Au alloy nanoparticles-impregnated glassy carbon electrode

Yadav, Reetu; Kushwah, Vinod Kuumar; Gaur, M. S.; Bhadauria, Seema; Berlina, Anna N.; Zherdev, Anatoly V.; Dzantiev, Boris B.

doi:10.1080/03067319.2019.1638371

Cited by 22 publications

(7 citation statements)

References 31 publications

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“…The detection limit for the prepared sensor was 0.092 ppb. Yadav and his colleagues [ 138 ] reported an electrochemical aptasensor based on aptamers and Ag–Au alloy nanomaterials (Ag–Au alloy NPs) to detect As 3+ . The sensor was used As 3+ aptamer deep trapped Ag-Au alloy NPs which modified glassy carbon electrode.…”

Section: Aptasensors For Heavy Metals Ion Detectionmentioning

confidence: 99%

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

et al. 2021

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Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cause serious threat to human health. However, the conventional methods to detect heavy metal ions are more strictly to the requirements by detection equipment, sample pretreatment, experimental environment, etc. Aptasensor has the advantages of strong specificity, high sensitivity and simple preparation to detect small molecules, which provides a new direction platform in the detection of heavy metal ions. This paper reviews the selection of aptamers as target for heavy metal ions since the 21th century and aptasensors application for detection of heavy metal ions that were reported in the past five years. Firstly, the selection methods for aptamers with high specificity and high affinity are introduced. Construction methods and research progress on sensor based aptamers as recognition element are also introduced systematically. Finally, the challenges and future opportunities of aptasensors in detecting heavy metal ions are discussed.

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Section: Aptasensors For Heavy Metals Ion Detectionmentioning

confidence: 99%

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

et al. 2021

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“…In a much more sensitive variation of this method, Yadav et al [ 113 ] reported the use of a glassy carbon electrode modified with silver and gold (Ag-Au) alloy NPs loaded with Apt-3 (or an analog thereof) and cyclic voltammetry. Captured As(III) ions undergo electrochemical reaction, thus producing a significant increase in the current.…”

Section: Food and Water Analysismentioning

confidence: 99%

Recent advances in aptamer applications for analytical biochemistry

Zon

2022

Analytical Biochemistry

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Aptamers are typically defined as relatively short (20–60 nucleotides) single-stranded DNA or RNA molecules that bind with high affinity and specificity to various types of targets. Aptamers are frequently referred to as “synthetic antibodies” but are easier to obtain, less expensive to produce, and in several ways more versatile than antibodies. The beginnings of aptamers date back to 1990, and since then there has been a continual increase in aptamer publications. The intent of the present account was to focus on recent original research publications, i.e., those appearing in 2019 through April 2020, when this account was written. A Google Scholar search of this recent literature was performed for relevance-ranking of articles. New methods for selection of aptamers were not included. Nine categories of applications were organized and representative examples of each are given. Finally, an outlook is offered focusing on “faster, better, cheaper” application performance factors as key drivers for future innovations in aptamer applications.

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“…The contamination of water sources by heavy metals, such as arsenic, cadmium, lead, silver, and mercury, can lead to multiple adverse effects on human health and aquatic life (Yadav et al, 2019). These issues are further compounded by the tendency of heavy metals to bioaccumulate in living systems (Malik et al, 2019).…”

Section: Aptamer-based Biosensors For the Detection Of Heavy Metals Imentioning

confidence: 99%

“…These issues are further compounded by the tendency of heavy metals to bioaccumulate in living systems (Malik et al, 2019). Liquid effluent and industrial waste are major contamination sources to natural water systems like river and groundwater (Yadav et al, 2019). One of the most common strategies for heavy metal detection is to employ electrochemical methods (Rapini and Marrazza, 2017;Mishra et al, 2018;Malik et al, 2019).…”

Section: Aptamer-based Biosensors For the Detection Of Heavy Metals Imentioning

confidence: 99%

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Aptamer-Based Biosensors for Environmental Monitoring

2020

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Due to their relative synthetic and chemical simplicity compared to antibodies, aptamers afford enhanced stability and functionality for the detection of environmental contaminants and for use in environmental monitoring. Furthermore, nucleic acid aptamers can be selected for toxic targets which may prove difficult for antibody development. Of particular relevance, aptamers have been selected and used to develop biosensors for environmental contaminants such as heavy metals, small-molecule agricultural toxins, and water-borne bacterial pathogens. This review will focus on recent aptamer-based developments for the detection of diverse environmental contaminants. Within this domain, aptamers have been combined with other technologies to develop biosensors with various signal outputs. The goal of much of this work is to develop cost-effective, user-friendly detection methods that can complement or replace traditional environmental monitoring strategies. This review will highlight recent examples in this area. Additionally, with innovative developments such as wearable devices, sentinel materials, and lab-on-a-chip designs, there exists significant potential for the development of multifunctional aptamer-based biosensors for environmental monitoring. Examples of these technologies will also be highlighted. Finally, a critical perspective on the field, and thoughts on future research directions will be offered.

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Electrochemical aptamer biosensor for As³⁺based on apta deep trapped Ag-Au alloy nanoparticles-impregnated glassy carbon electrode

Cited by 22 publications

References 31 publications

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Recent advances in aptamer applications for analytical biochemistry

Aptamer-Based Biosensors for Environmental Monitoring

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Electrochemical aptamer biosensor for As3+based on apta deep trapped Ag-Au alloy nanoparticles-impregnated glassy carbon electrode

Cited by 22 publications

References 31 publications

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Advances in aptamer screening and aptasensors’ detection of heavy metal ions

Recent advances in aptamer applications for analytical biochemistry

Aptamer-Based Biosensors for Environmental Monitoring

Contact Info

Product

Resources

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Electrochemical aptamer biosensor for As³⁺based on apta deep trapped Ag-Au alloy nanoparticles-impregnated glassy carbon electrode