Electrochemical aptamer-based biosensing of glycan-conjugated targets

Lv, Junpeng; Wan, Jianwen; Wu, Di; Ye, Zhuojun; Tian, Yiyan; Hong, Mingru; Chen, Songmin; Liu, Yutong; Wang, Mengge; Hu, Qiong; Han, Dongxue; Niu, Li

doi:10.1016/j.bioana.2023.12.003

Cited by 4 publications

(2 citation statements)

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“…29,30 Taking Gal, Fuc, and Man as examples, it can be seen that the glycans of antibodies carry tens of the vicinal diol sites. 28,31 As the diol sites can covalently cross-link with the boronic acid group, 32,33 the attached glycans can be harnessed for the amplified detection of antibody pharmaceuticals.…”

Section: Metrics and Morementioning

confidence: 99%

“…Antibodies are glycoproteins bearing two biantennary glycan chains, , typically composed of a core pentasaccharide and varying numbers of galactose (Gal), N -acetylneuraminic acid (NeuNAc), fucose (Fuc), mannose (Man), and N -acetylglucosamine (GlcNAc) . During the course of glycosylation, the glycans are attached to the conserved asparagine residue at position 297 (Asn-297) in the C H 2 domain of the fragment crystallizable region, and they are the main effectors of the antibody-dependent cellular cytotoxicity (ADCC) and the complement-dependent cytotoxicity (CDC) of antibody pharmaceuticals. , Taking Gal, Fuc, and Man as examples, it can be seen that the glycans of antibodies carry tens of the vicinal diol sites. , As the diol sites can covalently cross-link with the boronic acid group, , the attached glycans can be harnessed for the amplified detection of antibody pharmaceuticals.…”

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confidence: 99%

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