Electrochemical and spectroscopic studies of the interaction of antiviral drug Tenofovir with single and double stranded DNA

Morawska, Kamila; Popławski, Tomasz; Ciesielski, Witold; Smarzewska, Sylwia

doi:10.1016/j.bioelechem.2018.06.002

Cited by 39 publications

(20 citation statements)

References 34 publications

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“…Indeed, the effect of antioxidants like caffeic acid was recently monitored electrochemically towards the binding ability of Daunorubicin, a DNA-intercalating molecule used to treat leukemia [37]. A recent example of the interactions between DNA and an antiviral molecule, Tenofovir, was also recently reported [38].…”

Section: Electrochemical Behavior Of Redox Enzymes Towards Drugsmentioning

confidence: 99%

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Buriez

Labbé

2020

Current Opinion in Electrochemistry

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Electrochemical methods provide a wide range of strategies to explore the metabolism of drugs. These approaches traditionally encompass preparative aspects viz. the electrochemical generation of potent metabolites or the electrochemical exploration of the reactivity of redox enzymes (or their mimics) towards drugs. More recently the electroanalytical characterization of the successive redox and redoxcoupled reactions was found effective to unravel more complex mechanisms, especially those related to the reactivity of bioorganometallic drugs. This minireview highlights the contribution of these different electrochemical strategies to the determination of drug metabolism through representative recent examples.

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Section: Electrochemical Behavior Of Redox Enzymes Towards Drugsmentioning

confidence: 99%

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Buriez

Labbé

2020

Current Opinion in Electrochemistry

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“…Table 2 ), it can be concluded that the developed methodology has several advantages. The linear concentration range lays in the submicromolar region, while most of reported in other papers are micromolar and higher [ 10 , 11 , 12 ], and only one of the methods is more sensitive in this respect [ 13 ]. Moreover, it is worth mentioning that the method using oxidation at GO/GCE covers a full two-fold concentration range, which is not so common within other electrochemical methods of TFV detection.…”

Section: Resultsmentioning

confidence: 99%

“…Many chromatographic and spectrophotometric methods for Tenofovir detection are known [ 5 , 6 , 7 , 8 , 9 ], while there are only few electrochemical ones [ 10 , 11 , 12 , 13 , 14 ]. Due to sensitivity, the cathodic potential window, and reproducibility, mercury electrodes are unique.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Determination of Tenofovir in Pharmaceutical Formulations and Patients Urine—Comparative Electroanalytical Studies Using Different Sensing Methods

et al. 2022

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This paper discusses the electrochemical behavior of antiviral drug Tenofovir (TFV) and its possible applicability towards electroanalytical determination with diverse detection strategies using square-wave voltammetry. Namely, oxidation processes were investigated using glassy carbon electrode with graphene oxide surface modification (GO/GCE), while the reduction processes, related to the studied analyte, were analyzed at a renewable silver amalgam electrode (Hg(Ag)FE). Scanning electron microscopy imaging confirmed the successful deposition of GO at the electrode surface. Catalytic properties of graphene oxide were exposed while being compared with those of bare GCE. The resultant modification of GCE with GO enhanced the electroactive surface area by 50% in comparison to the bare one. At both electrodes, i.e., GO/GCE and Hg(Ag)FE, the TFV response was used to examine and optimize the influence of square-wave excitation parameters, i.e., square wave frequency, step potential and amplitude, and supporting electrolyte composition and its pH. Broad selectivity studies were performed with miscellaneous interfering agents influence, including ascorbic acid, selected saccharides and aminoacids, metal ions, non-opioid analgesic metamizole, non-steroidal anti-inflammatory drug omeprazole, and several drugs used along with TFV treatment. The linear concentration range for TFV determination at GO/GCE and Hg(Ag)FE was found to be 0.3–30.0 µmol L–1 and 0.5–7.0 µmol L–1, respectively. The lowest LOD was calculated for GO/GCE and was equal to 48.6 nmol L–1. The developed procedure was used to detect TFV in pharmaceutical formulations and patient urine samples and has referenced utilization in HPLC studies.

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“…The variation in the peak current can be exploited for the determination of binding constant and binding size, whereas the shift in peak potential can be used to ascertain the mode of interaction (18,31). Drugs that have been studied using CV and related techniques are nogalamycin, efavirenz, flutamide, anthracyclines, cisplatin, etopside and nevirapine [32][33][34][35][36][37].…”

Section: Voltammetrymentioning

confidence: 99%

Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

2019

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The interaction of drugs with DNA has been searched thoroughly giving rise to an endless number of findings of undoubted importance, such as a prompt alert to harmful substances, ability to explain most of the biological mechanisms, or provision of important clues in targeted development of novel chemotherapeutics. The existence of some drugs that induce oxidative damage is an increasing point of concern as they can cause cellular death, aging, and are closely related to the development of many diseases. Because of a direct correlation between the response, strength/ nature of the interaction and the pharmaceutical action of DNA‐targeted drugs, the electrochemical analysis is based on the signals of DNA before and after the interaction with the DNA‐targeted drug. Nowadays, nanoscale materials are used extensively for offering fascinating characteristics that can be used in designing new strategies for drug‐DNA interaction detection. This work presents a review of nanomaterials (NMs) for the study of drug‐nucleic acid interaction. We summarize types of drug‐DNA interactions, electroanalytical techniques for evidencing these interactions and quantification of drug and/or DNA monitoring.

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Electrochemical and spectroscopic studies of the interaction of antiviral drug Tenofovir with single and double stranded DNA

Cited by 39 publications

References 34 publications

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Disclosing the redox metabolism of drugs: The essential role of electrochemistry

Highly Sensitive Determination of Tenofovir in Pharmaceutical Formulations and Patients Urine—Comparative Electroanalytical Studies Using Different Sensing Methods

Nanomaterial‐based Sensors for the Study of DNA Interaction with Drugs

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