Electrochemical and Spectrophotometric Evaluation of the Formation Constants of the AA-βCD and DA-βCD Inclusion Complexes

Ángeles, Georgina Alarcón; Corona-Avendaño, S.; Palomar-Pardavé, M.; Romero-Romo, M.; Rojas-Hernándéz, Alberto; Ramı́rez-Silva, Maria Teresa

doi:10.1149/1.3046667

Cited by 2 publications

References 6 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Electrochemical study of weak inclusion complex interactions by simultaneous MCR-ALS analyses of potential step-chronoamperometric data matrices

2012

View full text Add to dashboard Cite

In this article, the analytical information obtained from the chronoamperometric data of a weak hostguest complexation was analyzed by multivariate curve resolution-alternative least square (MCR-ALS) as a powerful chemometrics method. As a model system, the complexation of dopamine with bcyclodextrin was investigated. Whilst the voltammetric behavior of dopamine does not change significantly upon complexation, its chronoamperogram is changed due to the formed complex. The analysis was performed by titrating dopamine (guest) with variable amounts of b-cyclodextrin (host). In each mole ratio of host : guest, the solution was subjected to a potential step experiment, where in each step the current was measured as a function of time. Thus, for each potential a two-fold array of current data with molar ratio in one direction and time in another direction (data matrix) was obtained. The data matrices collected at different potentials were simultaneously analyzed by MCR-ALS to earn thermodynamic parameters (e.g., stoichiometric ratio and formation constant) of cyclodextrindopamine complex. This is the first report of simultaneous analysis of potential stepchronoamperometric data matrices by MCR-ALS.

show abstract