Electrochemical and spectroelectrochemical properties of thiadiazole substituted metallo-phthalocyanines

Demirbaş, Ümit; Akyüz, Duygu; Barut, Burak; Bayrak, Rıza; Kanteki̇n, Hali̇t

doi:10.1016/j.saa.2015.07.105

Cited by 30 publications

(10 citation statements)

References 32 publications

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“…In the UV-Vis spectrum, the Q band of compound 4 was monitored at 679 nm and the B band was monitored at 353 nm. All characterization data are in accordance with the literature about the metallophthalocyanines [26,27].…”

Section: Synthesis and Characterizationsupporting

confidence: 84%

Synthesis, characterization, and investigation of singlet oxygen, DNA interaction,and topoisomerase I inhibition properties of novel zinc(II) phthalocyanine

Demirbaş¹

2019

Turk J Chem

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In this work, phthalonitrile (3) and zinc(II) phthalocyanine (4) were prepared. To determine the photodynamic therapy potential of compound 4, singlet oxygen quantum yield, DNA binding and cleavage, and topoisomerase I inhibition experiments were performed. The singlet oxygen quantum yield value of compound 4 was found higher than that of the standard unsubstituted zinc(II) phthalocyanine compound (Std-ZnPc). The binding experiments showed that compound 4 interacted with ct-DNA strongly via nonintercalation mode. pBR322 plasmid DNA cleavage activity of the compound was investigated using agarose gel electrophoresis. The results showed that the compound 4 had important DNA cleavage activity. The E. coli DNA topoisomerase I inhibition effects of compound 4 were investigated using agarose gel electrophoresis. Compound 4 had an E. coli topoisomerase I inhibitory effect at increasing concentrations.The results showed that compound 4 has photosensitizer potential in photodynamic therapy.

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Section: Synthesis and Characterizationsupporting

confidence: 84%

Synthesis, characterization, and investigation of singlet oxygen, DNA interaction,and topoisomerase I inhibition properties of novel zinc(II) phthalocyanine

Demirbaş¹

2019

Turk J Chem

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“…The MgPc gives the Q band at 680 nm with shoulder at 615 nm as shown in Figure 5a. During the first reduction process at −0.85 V, the intensity of Q band increased, which can stem from the disaggregation of the aggregate species [16a]. Then, the intensity of Q band decreased, and new bands were observed at 425 nm and 578 nm, during the second reduction process under −1.20 V. When applied more negative potential (‐2.20 V), the intensity of spectrum decreases, and a new peak occurs at 542 nm (Figure 5b).…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization and Investigation of Electrochemical and Spectroelectrochemical Properties of Peripherally Tetra Diethoxypropan Substituted Phthalocyanines

2020

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In this study novel peripherally tetra 1,3‐diethoxy‐2‐propanol substituted Co(II), Cu(II), Mg(II), Ni(II) Zn(II) phthalocyanine derivatives were prepared. The characterization of the novel compounds was made by FT‐IR, 1H‐NMR, UV‐vis and MALDI‐TOF mass. Electrochemical, in‐situ spectroelectrochemical and electrocolorimetric measurements have been carried out with the aim to determine the redox properties, to illuminate reaction mechanism and the effect of substituent and metal center. Moreover, the color properties and aggregation tendency of compounds were also investigated.

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“…The characterization data of the phthalonitrile (3) are in harmony with the literature about the substituted phthalonitriles. [23,24] The phthalocyanine complexes (4-6) were prepared by using the compound (3). In the vibrational spectra of phthalocyanines, disapperance of nitrile vibrations showed that reaction was completed.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Synthesis, Characterization, Photophysical and Photochemical Properties of Novel Phthalocyanines

Demirbaş

2020

ChemistrySelect

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The benzothiazole substituted phthalonitrile (3) and nonperipherally tetra benzothiazole substituted metal-free (4), zinc (II) (5) and lead(II) phthalocyanine (6) complexes were prepared. The compounds (3-6) were characterized by IR, NMR, UV-Vis and mass spectroscopy data. After synthesis, photochemical and photophysical parameters of the compounds (4-6) were analyzed to determine photosensitizer performance of them for PDT applications. Firstly, the most suitable solvent for compounds (4-6) was found by aggregation studies. Then, fluorescence properties were measured in DMF at 1x10 À 6 M. Singlet oxygen properties were measured in DMF by using 1,3diphenylisobenzofuran (DPBF) as a singlet oxygen quencher. Photodegradation properties were measured under light irradiation in DMF at 1x10 À 5 M. The zinc(II) phthalocyanine (5) had the highest singlet oxygen production capacity (Φ~= 0.62), fluorescence (Φ F = 0.25) and photodegradation quantum yield (Φ d = 3.28x10-4). The results showed that zinc(II) phthalocyanine (5) has potential for photodynamic therapy applications.

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Electrochemical and spectroelectrochemical properties of thiadiazole substituted metallo-phthalocyanines

Cited by 30 publications

References 32 publications

Synthesis, characterization, and investigation of singlet oxygen, DNA interaction,and topoisomerase I inhibition properties of novel zinc(II) phthalocyanine

Synthesis, characterization, and investigation of singlet oxygen, DNA interaction,and topoisomerase I inhibition properties of novel zinc(II) phthalocyanine

Synthesis, Characterization and Investigation of Electrochemical and Spectroelectrochemical Properties of Peripherally Tetra Diethoxypropan Substituted Phthalocyanines

Synthesis, Characterization, Photophysical and Photochemical Properties of Novel Phthalocyanines

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