Electrochemical Affinity Sensors Using Field Effect Transducer Devices for Chemical Analysis

Abstract

The review presents advances and main challenges of the affinity sensors based on field-effect transistors published during the last five years. The different nanomaterial-based field-effect transistors are classified according to the nature of the nanomaterials, beginning by silicon, the "gold-standard" semiconductor, the gallium nitride semiconductor, the organic semiconductors, the silicon nanowires, the inorganic nanomaterials, the carbon nanotubes and the graphene. Due to its exceptional electrical properties, the main works are devoted to graphene. The obtained analytical performances for the detection of biomarkers, of DNA sequences and of miRNA are listed. The relation between the operational conditions -nature of the nanomaterials, procedure of preparation, choice of the receptor molecule, method of immobilization -and the analytical performance are discussed. The perspective of industrialization of these affinity sensors based on field-effect transistors is discussed.

Modern Electrochemical Biosensing Based on Nucleic Acids and Carbon Nanomaterials

“…In turn, after functionalization, they can then be harnessed as DNA sensor transducers [ 118 ]. With an excellent carrier mobility (>200,000 cm 2 V −1 s −1 ) and 100% surface atoms, it appears to be even better than the nanotubes or nanofibers described earlier [ 119 ]. Therefore, an FET sensor was constructed for the simultaneous detection of six different DNA sequences.…”

晶体管生物传感：界面调控策略及生物医学应用

“…高选择性和可靠稳定的 FET 生物传感器 [17,18] . 本文总结了近十年高性能 1 传感材料 在 FET 生物传感中，漏源电流(I ds )或阈值电压(V th )的偏移是精准定量待测靶 标浓度的依据 [7] .…”