Electroceuticals for peripheral nerve regeneration

Maeng, Woo-Youl; Tseng, Wan Ling; Li, Song; Koo, Jahyun; Hsueh, Yuan Yu

doi:10.1088/1758-5090/ac8baa

Cited by 19 publications

(30 citation statements)

References 176 publications

(256 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, the differentiation of PC12 cells was detected by examining the expression of neuron-specific class III beta-tubulin (Tuj1), and immunofluorescence staining (Figure S6) showed that the number of Tuj1-positive neuron cells was significantly increased on the Bi 2 S 3 /Ti 3 C 2 T x -PLLA group with NIR light irradiation . The results indicated that the photocurrent generated by the Bi 2 S 3 /Ti 3 C 2 T x -PLLA conduit could effectively promote PC12 differentiation into neurons …”

Section: Resultsmentioning

confidence: 99%

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Chen

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Bismuth sulfide (Bi2S3) enabled us to transform light signals into electrical signals via the photoelectric effect, which exhibited tremendous prospects on constructing wireless electrical stimulation for accelerating nerve regeneration. However, too rapid recombination of photogenerated electron–hole pairs weakened its photocurrent. Herein, the Bi2S3/Ti3C2T x heterojunction was synthesized by in situ growth of Bi2S3 nanoparticles on Ti3C2T x nanosheets and then mixed with poly-l-lactic acid (PLLA) powder to fabricate the Bi2S3/Ti3C2T x -PLLA conduit. At the heterojunction interfaces, Ti3C2T x with a more positive Fermi energy level could form interfacial potential difference with Bi2S3 to promote electron–hole pair separation. Meanwhile, Ti3C2T x with excellent conductivity could provide channels for photogenerated electron transmission, thus facilitating the generation of the photocurrent. Photoluminescence and electrochemical impedance spectroscopy analysis indicated that electron–hole pair separation and electron transfer were enhanced. As a consequence, under near-infrared light radiation, the output photocurrent of Bi2S3/Ti3C2T x -PLLA was increased from 0.48 to 1.43 μA compared to that of Bi2S3-PLLA. The enhanced photocurrent effectively promoted the differentiation of rat pheochromocytoma (PC12) into functional neurons by upregulating extracellular Ca2+ influx. Therefore, the above results demonstrated that this work provided a new perspective for wireless electrical stimulated nerve regeneration.

show abstract

Section: Resultsmentioning

confidence: 99%

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Chen

et al. 2023

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…Moreover, such smart hydrogels can incorporate drugs or growth factors that will be released in a controlled manner upon electrical stimulation [ 150 ]. Based on the latest technological advances on the wireless stimulation of conductive hydrogels [ 151 , 152 ], it might be possible that in the future patients with AC and osteochondral defects can be treated more comfortably at home through the use of a wireless device able to promote tissue regeneration through the controlled electrical stimulation of implanted conductive cartilage substitutes.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Electrically Conductive Hydrogels for Articular Cartilage Tissue Engineering

Miguel

Barbosa

Ferreira

et al. 2022

Gels

View full text Add to dashboard Cite

Articular cartilage is a highly specialized tissue found in diarthrodial joints, which is crucial for healthy articular motion. Despite its importance, articular cartilage has limited regenerative capacities, and the degeneration of this tissue is a leading cause of disability worldwide, with hundreds of millions of people affected. As current treatment options for cartilage degeneration remain ineffective, tissue engineering has emerged as an exciting approach to create cartilage substitutes. In particular, hydrogels seem to be suitable candidates for this purpose due to their biocompatibility and high customizability, being able to be tailored to fit the biophysical properties of native cartilage. Furthermore, these hydrogel matrices can be combined with conductive materials in order to simulate the natural electrochemical properties of articular cartilage. In this review, we highlight the most common conductive materials combined with hydrogels and their diverse applications, and then present the current state of research on the development of electrically conductive hydrogels for cartilage tissue engineering. Finally, the main challenges and future perspectives for the application of electrically conductive hydrogels on articular cartilage repair strategies are also discussed.

show abstract

“…The use of electroceuticals in peripheral nerve injury (PNI) treatment has been explored for years [ 20 ]. While the application of percutaneous electrical stimulation (ES) is quite established in clinical settings [ 21 ], direct ES treatment on injured nerves is a far less explored approach, and data on this subject, especially concerning in vivo experiments, is limited.…”

Section: Introductionmentioning

confidence: 99%

Does Electrical Stimulation through Nerve Conduits Improve Peripheral Nerve Regeneration?—A Systematic Review

Hasiba-Pappas

Kamolz

Luze

et al. 2023

JPM

View full text Add to dashboard Cite

Background: Peripheral nerve injuries affect over 2% of trauma patients and can lead to severe functional impairment and permanent disability. Autologous nerve transplantation is still the gold standard in the reconstruction of nerve defects. For small defects, conduits can be considered for bridging. Lately, the combined use of conduits and electrical stimulation has gained attention in the treatment of peripheral nerve injury. This review aimed to present the currently available data on this topic. Methods: PubMed, Embase, Medline and the Cochrane Library were searched for studies on electrical stimulation through nerve conduits for nerve defects in in vivo studies. Results: Fifteen studies fit the inclusion criteria. All of them reported on the application of nerve conduits combined with stimulation for sciatic nerve gaps in rats. Functional, electrophysiological and histological evaluations showed improved nerve regeneration after electrical stimulation. High variation was observed in the treatment protocols. Conclusion: Electrically stimulated conduits could improve peripheral nerve regeneration in rat models. The combined application of nerve guidance conduits and electrical stimulation shows promising results and should be further evaluated under standardized conditions.

show abstract

Electroceuticals for peripheral nerve regeneration

Cited by 19 publications

References 176 publications

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Electrically Conductive Hydrogels for Articular Cartilage Tissue Engineering

Does Electrical Stimulation through Nerve Conduits Improve Peripheral Nerve Regeneration?—A Systematic Review

Contact Info

Product

Resources

About

Electroceuticals for peripheral nerve regeneration

Cited by 19 publications

References 176 publications

Photoelectric Bi2S3 Nanoparticle/Ti3C2Tx Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Photoelectric Bi2S3 Nanoparticle/Ti3C2Tx Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Electrically Conductive Hydrogels for Articular Cartilage Tissue Engineering

Does Electrical Stimulation through Nerve Conduits Improve Peripheral Nerve Regeneration?—A Systematic Review

Contact Info

Product

Resources

About

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth

Photoelectric Bi₂S₃ Nanoparticle/Ti₃C₂T_x Nanosheet Heterojunction for Promotion of Nerve Cell Growth