Electrocatalytic Reduction of Disulfide Bonds across Chemical Modalities
Serge Ruccolo,
Marion Emmert,
Cecilia Bottecchia
et al.
Abstract:The chemical properties of disulfides are leveraged in a wide array of applications, ranging from protein−drug conjugates for cancer treatment to self-healing materials. However, disulfide reduction strategies remain severely underdeveloped despite being the key to efficiently accessing the desired targets. Specifically, no homogeneous catalyst has been reported for this reaction, and conditions that allow the use of mild and green reductants (e.g., via electrochemical reduction) are not known. Herein, we unve… Show more
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