Electrocatalytic oxidative C–H cycloamination towards tricyclic [1,2,4]triazolo-[3,4-i]purine nucleosides mediated by bromide ions

Abstract

A environmentally benign electrochemical approach is presented to access diversely functionalized [1,2,4]triazolo[3,4-i]purine heterocyclic framework. The bromide-mediated indirect oxidation strategy was utilized to promote intramolecular C(sp2)–H cycloamination in high efficiency and...

Electrochemical C(sp2)–H/N–H “formal” cross-dehydrogenative coupling of olefins with benzotriazoles for synthesis of N-vinyl benzotriazoles

“…Therefore, we speculate that when n Bu 4 NBr is used in place of n Bu 4 NI, the reaction may follow the same pathway, with Br − serving a similar function as I − . 16 (For the possible explanations for the elimination of HI from 8a to yield 3a, see ESI §5.3 and §5.4. † The possible reaction mechanism with n Bu 4 NBr is shown in Fig.…”