Electrocatalytic Oxidation and Sensitive Determination of Paracetamol Based on Nanosheets Self‐assembled Lindgrenite Microflowers

Abstract

In this work, the nanosheet‐assembled lindgrenite microflowers (chemical formula: Cu3Mo2O9) were synthesised through a simple process and low‐cost raw materials at room temperature in aqueous solution without using any surface‐active agent. The tightly interlaced nanosheets, like petals, can increase the specific surface area, which can bring about higher electrocatalytic activity and electroanalysis sensitivity. Thus, lindgrenite microflowers were prepared as an electrochemical sensor and successfully applied in the detection of paracetamol through the modified glass carbon electrode. Furthermore, this electrochemical reaction process was simulated at the ab‐initio level to reveal the catalytic mechanism, and the simulation results agreed well with electrochemical experiments. The electrochemical performance of the lindgrenite microflowers modified glassy carbon electrode (GCE) was studied by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The linearity of paracetamol ranged from 0.05 to 1200 μM (IT method) and 0.05 to 1000 μM (DPV method), low detection limit (0.01 μM) and high sensitivity (5.11 mA mM−1 cm−2) towards paracetamol. Moreover, this sensor was applied to detect paracetamol in human blood serum samples. The excellent results demonstrated that the prepared electrode not only showed a desirable linear range towards paracetamol but also exhibited practical applicability and reliability towards human serum samples detection.

Ordered Mesoporous Silica Incorporating Platinum Nanoparticles as Electrode Material for Paracetamol Detection

“…As seen in table 4, the glassy carbon electrodes based on Cu 3 Mo 2 O 9 [14] or graphite oxide [46], and MWCNT‐BPPGE (multiwalled carbon nanotube modified basal plane pyrolytic graphite electrode) [48a] have larger linear domains and a significantly decreased detection limits for PA, in comparison with Pt/M−SBA‐15‐GPE (where M=Al−, B− or Al−B−), due to the presence of materials with higher conductivities into electrode composition. Even so, the present work brings important advantages in the field of sensors proved by the use for the first time, from the best of our knowledge, of the Pt/M−SBA‐15 (where M=Al−, B− or Al−B−) nanocomposites, as electrode material for PA detection, with comparable analytical parameters with other already published works.…”

“…For PA detection were used different chemically modified electrodes containing: conducting polymers, multiwall carbon nanotubes (MWCNT), magnetic microparticles (MPs), metallic nanoparticles, enzymes or graphene (Gr). Thus, were reported many modified electrodes such as: Au/MWCNT/PANI) [13], GCE/Cu 3 Mo 2 O 9 [14], Au/imprinted PANI [15], poly(p‐aminobenzene sulfonic acid/GCE [16]), MWCNT‐PtNPs composite carbon paste electrode [13, 17], MWCNT‐LAC/GCE [18], CQDs/ZnO NFs/Poly(CTAB)/GCE [19], printex 6 L carbon nanoballs/GCE [20], Bi‐nanoparticles/Nafion/BDDE [21], polyphenol oxidases [13], carbon paste electrode [14], PtMWCNTs–TX100‐CPE [22], nevirapine/CPE [23], MWCNTs‐Nafion/GCE [24], AuNPs@TC8 A/GN/GCE [25].…”

Differential pulse stripping voltammetric determination of paracetamol in pharmaceutical tablet samples using murexide modified carbon paste electrode

“…Graphene chitosan (GR-CS) nanocomposite/GCE DPV 0.3 (Zheng et al, 2013) Ethynylferrocene (EF) and NiO/MWCNT nanocomposite/CPE SWV 0.5 (Shahmiri et al, 2013) Nanosheet-assembled lindgrenite microflowers/GCE DPV 0.01 (Fu et al, 2020) MWCNTs/ZnO nanoparticles/GPE DPV 0.0033 (Patil et al, 2019) Phosphorus-doped graphene/GCE DPV 0.36 (Zhang et al, 2018) Murexide/CPE DPSV 0.09 This work…”

Highly Efficient Electrochemical Sensing of Acetaminophen by Cobalt Oxide-Embedded Nitrogen-Doped Hollow Carbon Spheres

“…Acetaminophen, commonly known as N -acetyl- p -aminophenol or acetaminophen, is one of the most widely utilized medications. It is mostly used to treat backaches, cancer pain, moderate to severe pain, colds, fevers, arthralgia, and neuralgia . In general, acetaminophen appears to be safe and has little harmful effects when used as directed by a doctor for an adult.…”

“…It is mostly used to treat backaches, cancer pain, moderate to severe pain, colds, fevers, arthralgia, and neuralgia. 1 In general, acetaminophen appears to be safe and has little harmful effects when used as directed by a doctor for an adult. However, if an adult consumes too much, uses it concurrently, or is hypersensitive, then it can cause liver damage, skin rashes, coma and in extreme cases, death.…”