Electrocatalytic Determination of the antibiotic Levofloxacin using modified carbon paste electrode with a poly‐murexide thin film voltammetrically

Abstract

In this work, a simple, cheap, sensitive, and selective modified carbon paste electrode is proposed for the electroanalytical determination of Levofloxacin (LEVO), the drug used to treat pneumonia caused by coronavirus. The electrochemical polymerization method was applied to create a thin poly-murexide film (POMUR) on the bare carbon paste electrode (BCPE) surface to enhance its electrocatalytic activity. The peak current response of LEVO obtained by POMUR/CPE was increased by 14.2 μA compared to BCPE. Scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques were employed to characterize BCPE and POMUR/CPE. Under the optimal experimental circumstances, the prepared sensor was capable of determining LEVO with a low limit of detection (LOD) of 7.18 nM (S/N = 3) for a linear dynamic range of 25 -1 × 10 3 nM utilizing differential pulse voltammetry (DPV). Moreover, the practical applicability of POMUR/CPE for determining LEVO in pharmaceutical formulations and biological samples (human serum) demonstrated high sensitivity and selectivity with a recovery of 95.08 -100.5 %.

Fabrication of Carbon Paste Sensor Activated with Electropolymerized DL‐Phenylalanine for the analysis of Levofloxacin

“…These methods offer numerous advantages, such as ease of operation, low power consumption, cost-effectiveness, rapid testing, miniaturization, low detection limits (LOD), and stability. [25][26][27][28][29] In this present research, we have developed a P(DLP/MCPE) sensor. This modified sensor illustrates multiple beneficial qualities, including a high level of sensitivity, an easy modification technique, being eco-friendly, and being cost-effective.…”

“…Electrochemical procedures are particularly suitable for the analysis of bioactive molecules in challenging samples, including biological, environmental, medicinal, and dietary samples. These methods offer numerous advantages, such as ease of operation, low power consumption, cost‐effectiveness, rapid testing, miniaturization, low detection limits (LOD), and stability [25–29] …”