Electrocatalytic determination of penicillamine using multiwall carbon nanotubes paste electrode and chlorpromazine as a mediator

Keyvanfard, Mohsen; Najjarian, Nazila; Alizad, Khadijeh

doi:10.1134/s1061934817100136

Cited by 8 publications

(4 citation statements)

References 29 publications

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“…Then, a curve can be plotted from a linear relationship between different D-PA concentrations (0.1 to 1.0 mM) and the obtained slopes from Inset A (see Inset B, Figure 4), leading to the calculation of a D value for D-PA (~8.2 × 10 −5 cm 2 s −1 ). The value of D is compared to 3.569 × 10 −6 cm 2 s −1 [16], 5.9 × 10 −4 cm 2 s −1 [18], 3.25 × 10 −5 cm 2 s −1 [20], 3.3 × 10 −5 cm 2 s −1 [22], and 2.5 × 10 −4 cm 2 s −1 [24].…”

Section: Chronoamperometric Analysismentioning

confidence: 99%

“…There have been various techniques for the detection of D-PA in various matrices, some of which are high-performance liquid chromatography with electrochemical (HPLC-EL) detection [11], HPLC with fluorescence (HPLC-FL) detection and capillary electrophoresis with laser-induced fluorescence (CE-LIF) detection [12], chemiluminescence detection [9], colorimetric detection [13], fluorescence detection [14,15], and electrochemical detection [5,[16][17][18][19][20][21][22][23][24]. However, some of these techniques suffer from some shortcomings, i.e., high cost, time consumption, and difficult pretreatment.…”

Section: Introductionmentioning

confidence: 99%

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Construction and Application of an Electrochemical Sensor for Determination of D-Penicillamine Based on Modified Carbon Paste Electrode

Mohammadnavaz,

Beitollahi,

Modiri

2024

Micromachines

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D-penicillamine (D-PA) is a sulfur-containing drug that has been used for various health conditions. However, like any medication, overdosing on D-PA can have adverse effects and may require additional treatment. Therefore, developing simple and sensitive methods for sensing D-PA can play a crucial role in improving its efficacy and reducing its side effects. Sensing technologies, such as electrochemical sensors, can enable accurate and real-time measurement of D-PA concentrations. In this work, we developed a novel electrochemical sensor for detecting D-PA by modifying a carbon paste electrode (CPE) with a multi-walled carbon nanotube-Co3O4 nanocomposite, benzoyl-ferrocene (BF), and ionic liquid (IL) (MWCNT-Co3O4/BF/ILCPE). Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry (CHA) were employed to explore the electrochemical response of D-PA on the developed sensor, the results of which verified a commendable electrochemical performance towards D-PA. Under optimized conditions, the developed sensor demonstrated a rapid response to D-PA with a linear dynamic range of 0.05 μM–100.0 μM, a low detection limit of 0.015 μM, and a considerable sensitivity of 0.179 μA μM−1. Also, the repeatability, stability, and reproducibility of the MWCNT-Co3O4/BF/ILCPE sensor were studied and showed good characteristics. In addition, the detection of D-PA in pharmaceutical and biological matrices yielded satisfactory recoveries and relative standard deviation (RSD) values.

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Section: Chronoamperometric Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Construction and Application of an Electrochemical Sensor for Determination of D-Penicillamine Based on Modified Carbon Paste Electrode

Mohammadnavaz,

Beitollahi,

Modiri

2024

Micromachines

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“…Several methods have been reported for the determination of D-PEN in pharmaceutical dosage forms including kinetic spectrophotometry [5], electrochemical chiral sensor [6], Flow-injection [7], Circular dichroism spectroscopy [8], spectrofluorimetric [9], Fluorometric sensor [10], HPLC [11,12], carbon paste electrode [13], HPLC-FLD and CE-LIF [14], spectrophotometric [15,16], potentiometric [17], fluorescence [18][19][20], Electrochemical sensor [21], Electrocatalytic [22], Chemiluminescence [23] and Voltametric [24].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation CFIA / MZ System as a Green Method for Determination of Thiol Drug (D-PEN)

Abdullah

Qassim

2021

Egypt. J. Chem.

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A simple, automated, and sensitive continuous flow-injection analysis/merging zones technique (CFIA/MZ) method was developed for the determination of D-Penicillamine (thiol drug) in pure, pharmaceutical formulations and biological samples. This method involved the reaction of 1,2-Naphthoquinone-4-Sulphonic acid Sodium Salt (NQS) with D-Penicillamine to produce a brown-colored complex that has maximum absorbance at 463 nm. The method was cheap, economic, precise and accurate where the limit of detection was 6.3 µg.mL -1 and the RSD% was 0.34 and Recovery was 99.31%. Various chemical and physical conditions that affected the reaction have been studied. A wide calibration curve was rectilinear within the concentration range (15-1000) μg.mL -1 with a sample throughput of 103 samples.hour -1 . The proposed procedure was applied successfully for the estimation of D-PEN in pharmaceutical and biological samples and the results obtained were favorably compared with those given by a reference method of United States Pharmacopoeia (USP), and there was no significant difference between the obtained results, regarding accuracy and precision at the 95% confidence level.

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“…To date, various methods have been developed for quantitative determination of d ‐PA including high performance liquid chromatography (HPLC), electrochemical methods, colorimetry, chemiluminescence methods, kinetic assays, and fluorescence. Specific to nanomaterial‐based fluorometry, by modifying or assembling nanomaterials, the use of these sensitive and simple detection approaches make fluorescence a popular choice with researchers .…”

Section: Introductionmentioning

confidence: 99%

Copper nanocluster‐based fluorescence enhanced determination of d‐penicillamine

Ren

Tang

et al. 2019

Luminescence

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Taking advantage of the compelling properties of D-penicillamine (D-PA) combined with copper, a method for the sensitive and selective determination of D-PA was established using copper nanocluster (Cu NC)-based fluorescence enhancement. D-PA molecules containing a thiol compound showed a strong tendency to combine with the surface of Cu NCs, causing the re-dispersion of nanoclusters and therefore fluorescence intensity was enhanced. Fluorescence enhancement efficiency of Cu NCs induced by D-PA was linear, with the D-PA concentration varying from 0.6-30 μg ml −1 (R 2 = 0.9952) and with a detection limit of 0.54 μg ml −1 . D-PA content in human urine samples was detected with recoveries of 104.8-112.99%. Fluorescence-enhanced determination of D-PA using Cu NCs was established for the first time and this rapid, easy and sensitive method should attract much attention for this application.

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Electrocatalytic determination of penicillamine using multiwall carbon nanotubes paste electrode and chlorpromazine as a mediator

Cited by 8 publications

References 29 publications

Construction and Application of an Electrochemical Sensor for Determination of D-Penicillamine Based on Modified Carbon Paste Electrode

Construction and Application of an Electrochemical Sensor for Determination of D-Penicillamine Based on Modified Carbon Paste Electrode

Development and Validation CFIA / MZ System as a Green Method for Determination of Thiol Drug (D-PEN)

Copper nanocluster‐based fluorescence enhanced determination of d‐penicillamine

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