Electrocatalytic (Bio)Nanostructures Based on Polymer-Grafted Platinum Nanoparticles for Analytical Purpose

Abstract

Functionalized platinum nanoparticles (PtNPs) possess electrocatalytic properties toward H2O2 oxidation, which are of great interest for the construction of electrochemical oxidoreductase-based sensors. In this context, we have shown that polymer-grafted PtNPs could efficiently be used as building bricks for electroactive structures. In the present work, we prepared different 2D-nanostructures based on these elementary bricks, followed by the subsequent grafting of enzymes. The aim was to provide well-defined architectures to establish a correlation between their electrocatalytic properties and the arrangement of building bricks. Two different nanostructures have been elaborated via the smart combination of surface initiated-atom transfer radical polymerization (SI-ATRP), functionalized PtNPs (Br-PtNPs) and Langmuir-Blodgett (LB) technique. The first nanostructure (A) has been elaborated from LB films of poly(methacrylic acid)-grafted PtNPs (PMAA-PtNPs). The second nanostructure (B) consisted in the elaboration of polymer brushes (PMAA brushes) from Br-PtNPs LB films. In both systems, grafting of the glucose oxidase (GOx) has been performed directly to nanostructures, via peptide bonding. Structural features of nanostructures have been carefully characterized (compression isotherms, neutron reflectivity, and profilometry) and correlated to their electrocatalytic properties toward H2O2 oxidation or glucose sensing.

A doxorubicin–platinum conjugate system: impacts on PI3K/AKT actuation and apoptosis in breast cancer cells

“…10 To date, several polymeric coated platinum-based nanoparticles are widely developed to study the electrochemical, catalytic properties, etc. [11][12][13] However, biological studies pertaining to polymeric platinum nanoparticles are limited. 14 Doxorubicin is an anthracycline-ringed antibiotic that treats a wide range of diseases, including cancer.…”

Circularly Polarized Luminescence of Langmuir–Schaefer Films of Amphiphilic Stilbene Enhanced via Interfacial Reaction with Cyclodextrins

“…However, as an interfacial assembly method, the LB or LS technique can be largely extended to various entities beyond amphiphiles. Various nanostructures such as nanotubes, , nanoparticles, , nanowires, , metal–organic frameworks (MOFs), 2D nanosheets, perovskites, and others were spread on the water surface to facilitate an array of nano-objects in a two-dimensional film. − Previously, we have reported the formation of LB films and CPL from an anthracene-appended amphiphilic molecule . An enhancement of the luminescent dissymmetry factor ( g lum ) was observed in the LB films compared to those in gels.…”

Spreading Films of Anthracene-Containing Gelator Molecules at the Air/Water Interface: Nanorod and Circularly Polarized Luminescence

“…Consequently, numerous amphiphiles have been designed and uniformly organized molecular films have been fabricated by the LB techniques at the air/water interface. With the development of nanotechnology, the LB technique is further deemed as a useful platform to construct nanostructure via the bottom-up approach. − At the same time, the techniques were proposed to provide two-dimensional nanostructures. − Except for the classical amphiphiles, nonclassical building blocks could be spread at the air/water interface, such as polymers, − nanoparticles, − nanowires, , nanotubes, , nanosheets, , etc., and varieties of nanostructures and their alignment were formed. Instead of the uniform molecular films, these nanostructured films could also be regulated and show potential applications in sensors, , electronic memory, and field-effect transistors .…”