Electrocardiographic T-wave parameters in families with long QT syndrome

Markiewicz-Łoskot, Grażyna; Moric-Janiszewska, Ewa; Mazurek, Bogusław; Łoskot, Marianna; Bartusek, Mariola; Skierska, Agnieszka; Szydłowski, Lesław

doi:10.17219/acem/68441

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…It was also found that the Tp-e/QTc ratio is also higher in high-risk patients, making it a useful risk marker. Furthermore, according to Markiewicz-Łoskot et al's study [ 58 ], Tp-e, combined with QTc, may have potential use in detecting affected relatives of people with congenital LQTS. They found that Tp-e is significantly longer in relatives affected by LQTS than in those unaffected and associated this marker with the possibility of cardiac events.…”

Section: Resultsmentioning

confidence: 99%

Tpeak‐Tend ECG Marker in Obesity and Cardiovascular Diseases: A Comprehensive Review

Dykiert,

Florek,

Kraik

et al. 2024

Scientifica

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Globally, cardiovascular diseases are still the leading cause of death. Numerous methods are used to diagnose cardiovascular pathologies; there is still a place for straightforward and noninvasive techniques, such as electrocardiogram (ECG). Depolarization and repolarization parameters, including QT interval and its derivatives, are well studied. However, the Tpeak‐Tend interval is a novel and promising ECG marker with growing evidence for its potential role in predicting malignant arrhythmias. In this review, we discuss the association between the Tpeak‐Tend interval and several cardiovascular diseases, including long QT syndrome, cardiomyopathies, heart failure, myocardial infarction, and obesity, which constitutes one of the risk factors for cardiovascular diseases.

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Section: Resultsmentioning

confidence: 99%

Tpeak‐Tend ECG Marker in Obesity and Cardiovascular Diseases: A Comprehensive Review

Dykiert,

Florek,

Kraik

et al. 2024

Scientifica

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“…The evaluation of repolarization period parameters, especially the TpTe interval, is useful in identifying patients at high risk of serious cardiac arrhythmias also in other clinical conditions such as short QT syndrome [44], long QT syndrome (LQTS) [45], hypertension [46,47], arrhythmogenic right ventricular cardiomyopathy [48], and in competitive sports [49]. The results of our own research are comparable to the opinions of many authors talking about the desirability of assessment in a 12-lead ECG, not only of the duration of the QT interval, but also the TpTe interval of the recognized new arrhythmogenesis index, which is considered a more sensitive prognostic parameter of ventricular arrhythmia compared to the one traditionally determined by QT interval [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of the TpTe Interval in Children with Ventricular Arrhythmias

Jaromin

Markiewicz-Łoskot

Szydłowski

et al. 2021

IJERPH

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Background: The changes in the period of ventricular repolarization, i.e., QT interval, QTp (Q-Tpeak) and TpTe interval (Tpeak–Tend), make it possible to assess the electrical instability of the heart muscle, which may lead to the development of life-threatening ventricular arrhythmia. The aim of the study was to determine and evaluate the use of differences in T-wave morphology and durations of repolarization period parameters (QT, TpTe) in resting ECGs for children with ventricular arrhythmias. Methods: The retrospective analysis was made of the disease histories of 80 examined children with resting ECGs, which were admitted to the Children’s Cardiology Department. The study group consisted of 46 children aged 4 to 18 with ventricular arrhythmias and the control group consisted of 34 healthy children between 4 and 18 years of age, with no arrhythmias. Results: The duration of the TpTe interval was significantly (p < 0.001) longer in the group of children with ventricular arrhythmia with abnormal T-wave (bactrian/bifid, humid/biphasic) compared to the TpTe interval in children with ventricular arrhythmia with the normal repolarization period. The duration of the TpTe (p < 0.001), QTcB (p < 0.001) and QTcF (p < 0.001) intervals were significantly longer in the group of children with ventricular arrhythmias and with abnormal T-wave compared to the values of the TpTe, QTcB, and QTcF intervals of the control group with normal morphology of the repolarization period. Only the duration of the TpTe interval was significantly (p = 0.020) longer in the group of children with ventricular arrhythmia without clinical symptoms. Conclusions: Children with benign ventricular arrhythmias recorded on a standard ECG with prolonged TpTe and QT intervals and abnormal T-wave morphology require systematic and frequent cardiac check up with long term ECG recordings due to the possibility of future more severe ventricular arrhythmias. Further follow-up studies in even larger groups of patients are necessary to confirm the values of these repolarization parameters in clinical practice.

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“…The questions of whether the TpTe interval reflects transmural repolarization heterogeneity or total dispersion of repolarization [ 13 , 14 ] is still a matter of debate. Therefore, in clinical practice, the TpTe interval is considered a more sensitive marker of arrhythmogenesis and increased risk of mortality in long QT syndrome (LQTS) compared to the QT interval [ 7 , 15 ]. In clinical evaluation, the TpTe interval, in addition to the QT interval, has been found amplified in patients with congenital and acquired LQTS [ 8 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Prolongation of Electrocardiographic T Wave Parameters Recorded during the Head-Up Tilt Table Test as Independent Markers of Syncope Severity in Children

Markiewicz-Łoskot

Kolarczyk

Mazurek

et al. 2020

IJERPH

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The head-up tilt table test (HUTT) with the upright phase is used to help determine an imbalance of the sympathetic nervous system that is related to abnormal electrocardiographic repolarization in children with vasovagal syncope (VVS) and also in patients with the long QT syndrome (LQTS). The study attempted to evaluate T wave morphology and QT and TpTe (Tpeak–Tend) intervals recorded in ECG during the HUTT for a more accurate diagnosis of children with VVS. The group investigated 70 children with a negative HUTT result: 40 patients with VVS and 30 healthy volunteers without syncope. The RR interval as well as TpTe, and QTc intervals were measured in lead V5 of electrocardiogram (ECG) on admission to the hospital and during three phases of the HUTT. In syncopal children, which included 23 children with bifid or flat T waves and 17 patients with normal T waves in the upright phase, the QTc and TpTe were longer (p < 0.001) compared to the other test phases and longer (p < 0.001) than in the control group, respectively, with the risk of arrhythmias. Only in the control group, the TpTe was shorter (p < 0.001) in the upright phase than in the other tilt phases. The TpTe in the upright phase (>70 ms) was a good discriminator, and was better than the QTc (>427 ms). Prolongation of electrocardiographic TpTe and QT intervals, in addition to the (abnormal T wave morphology recorded during the HUTT, are helpful for identifying VVS children more predisposed to ventricular arrhythmias with a latent risk of LQTS. Further studies are required to assess the value of these repolarization parameters in clinical practice.

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Electrocardiographic T-wave parameters in families with long QT syndrome

Cited by 5 publications

References 22 publications

Tpeak‐Tend ECG Marker in Obesity and Cardiovascular Diseases: A Comprehensive Review

Tpeak‐Tend ECG Marker in Obesity and Cardiovascular Diseases: A Comprehensive Review

Diagnostic Value of the TpTe Interval in Children with Ventricular Arrhythmias

Prolongation of Electrocardiographic T Wave Parameters Recorded during the Head-Up Tilt Table Test as Independent Markers of Syncope Severity in Children

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