Electrocardiographic remodeling during cardiac resynchronization therapy

Electrical Remodeling and Cardiac Dimensions in Patients Treated by Cardiac Resynchronization and Heart Failure Controls

“…20 The data on whether mechanical recovery of the heart and the more favorable prognosis is accompanied by restitution of spontaneous electrical activation are scarce and nonuniform. 19,21,22 Therefore, this study aims to comparatively characterize the course of spontaneous cardiac activation and structural remodeling in patients with severe systolic heart failure and left bundle branch block (LBBB) before and after long-term cardiac resynchronization therapy (CRT) and in matched heart failure control patients without LBBB.…”

Cardiac Resynchronization Therapy: Lead Positioning and Technical Advances

“…No change in intrinsic QRS duration was seen in the MUSTIC trial as well as in a study by Stockburger (Stockburger et al, 2008). Two studies displayed a trend towards a reduction in intrinsic QRS duration (Boriani et al, 2006;Vogt et al, 2000). Similar to our results, a retrospective study by Henrikson et al showed a significant reduction in intrinsic QRS duration after 14 months of CRT in 25 patients (Henrikson et al, 2007).…”

“…Especially patients with a very broad QRS-complex (> 150 msec) seem to profit most from CRT (Chung et al, 2008;Moss et al, 2009). Although QRS duration is not an optimal criterion for selecting patients amenable for CRT and some studies have failed to predict clinical and echocardiographic response to CRT, it remains an important criterion for dyssynchrony for the indication of CRT (Boriani et al, 2006;Gervais et al, 2009;Hawkins et al, 2006;Mollema et al, 2007).…”

“…The extent of the QRS shortening induced by biventricular pacing seems to correlate with the structural remodeling (Boriani et al, 2006;Kronborg et al, 2010). However, about one third of patients fail to respond to CRT (Cleland et al, 2001;Chung et al, 2008;Lafitte et al, 2009).…”

Effects of Cardiac Resynchronization Therapy on Ventricular Electrical Remodeling in Patients With Heart Failure

“…[4][5][6][7] Moreover, the results of several small scale studies and also a case report have suggested that CRT can reverse ventricular electrical remodeling. [8][9][10][11] It is currently hypothesized that successful reverse structural remodeling of the left ventricle during cardiac resynchronization therapy may induce improved ventricular electrical conduction in heart failure patients without the need for pacing the dual ventricular chambers. To test this hypothesis, we conducted a 2-year follow-up study of heart failure patients scheduled to receive a newly implanted cardiac pacemaker (CRT-P) or cardioverter defibrillator (CRT-D).…”