Electrocardiographic markers of structural heart disease and predictors of death in 2332 unselected patients undergoing outpatient Holter recording

Gallagher, Mark M.; Padula, Mina; Sgueglia, Marianna; Santini, Luca; Voci, Paolo; Mahon, Niall; Yap, Yee Guan; Romeo, Francesco

doi:10.1093/europace/eum228

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…In addition, the subjects in both aforementioned studies were in the acute post-MI period. The study by Gallagher et al 21 on 2332 unselected patients undergoing outpatient Holter monitoring found that the number of PVC morphologies predicted all-cause mortality.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Significance of Frequency and Morphology of Premature Ventricular Complexes during Ambulatory Holter Monitoring

Ephrem

Levine

Friedmann

et al. 2012

Noninvasive Electrocardiol

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Section: Discussionmentioning

confidence: 99%

The Prognostic Significance of Frequency and Morphology of Premature Ventricular Complexes during Ambulatory Holter Monitoring

Ephrem

Levine

Friedmann

et al. 2012

Noninvasive Electrocardiol

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“…Idiopathic premature ventricular contractions (PVCs) are characterised by the monomorphic pattern of ectopy on an otherwise normal 12-lead electrocardiogram (ECG), normal RR variability on 24-h Holter monitoring, and suppression of the PVCs with increasing heart rate at stress test. A normal echocardiogram may reinforce the diagnosis of benign PVCs [1]. Although some studies have linked PVCs to cardiomyopathy and left ventricular (LV) systolic dysfunction that is reversible after elimination of the frequent PVCs using catheter ablation [2][3][4], the mechanisms of these associations remain unclear in patients without underlying heart disease, and PVCs are generally considered benign [5,6].…”

Section: Introductionmentioning

confidence: 99%

Subclinical left atrium remodelling in patients with frequent premature ventricular contractions

et al. 2014

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“…The presence of multiform PVCs and the number of PVC morphologies were reported to be directly correlated with left ventricular dysfunction, cardiovascular (CV) adverse events, all-cause mortality, new-onset atrial fibrillation and heart failure, hospitalization, and cerebral thrombo-embolic events. 8 , 11 , 12 Pleomorphic PVCs might be associated with underlying subclinical heart disease that led to subsequent CV complications in these patients. 8 …”

Section: Discussionmentioning

confidence: 99%

Best ablation strategy in patients with premature ventricular contractions with multiple morphology: a single-centre experience

et al. 2023

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Aims This study aimed to examine the clinical benefits of targeted ablation of all Premature ventricular complex (PVC) morphologies vs. predominant PVC only. Methods and results A total of 171 consecutive patients with reduced left ventricular ejection fraction (LVEF) and ≥2 PVC morphology with high burden (>10%/day) undergoing their first ablation procedure were included in the analysis. At the initial procedure, prevalent PVC alone was ablated in the majority. However, at the redo, all PVC morphologies were targeted for ablation. : At the first procedure, 152 (89%) patients received ablation of the dominant PVC only. In the remaining 19 (11%) patients, all PVC morphologies were ablated. At two years, high PVC burden was detected in 89 (52%) patients. Repeat procedure was performed in 78 of 89, where all PVC morphologies were ablated. At 5 years after the repeat procedure, 71 (91%) had PVC burden of <5% [3.8 ± 1.1% vs. 15.4 ± 4.3% in successful vs. failed subjects (P < 0.001)]. In patients with low PVC burden after the initial procedure, LVEF improved from 37.5% to 41.6% [mean difference (MD): 3.39 ± 2.9%, P < 0.001], whereas a reduction in LVEF from 39.8% to 34.5% (MD: 6.45 ± 4.7%, P < 0.001) was recorded in patients with high PVC burden. One year after the repeat procedure, LVEF improved from 36.2% to 41.7% (MD: 5.5 ± 4.3%, P < 0.001) in patients with successful ablation. Conclusion In this observational series, ablation of all PVC morphologies was associated with significantly lower PVC burden and improvement of LVEF at long-term follow-up, compared with ablation of the dominant morphology only.

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Electrocardiographic markers of structural heart disease and predictors of death in 2332 unselected patients undergoing outpatient Holter recording

Abstract: VEQSI predicts the presence of structural heart disease. The number of VEB morphologies in a Holter recording predicts all-cause mortality.

Cited by 11 publications

References 19 publications

The Prognostic Significance of Frequency and Morphology of Premature Ventricular Complexes during Ambulatory Holter Monitoring

The Prognostic Significance of Frequency and Morphology of Premature Ventricular Complexes during Ambulatory Holter Monitoring

Subclinical left atrium remodelling in patients with frequent premature ventricular contractions

Best ablation strategy in patients with premature ventricular contractions with multiple morphology: a single-centre experience

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