Electrocardiographic features at rest and during exercise in young adults born preterm below 30 weeks of gestation

Gervais, Anne-Sophie; Flahault, Adrien; Chan, Tevy; Bastien-Tardif, Camille; Al-Simaani, Amy; Cloutier, Anik; Luu, Thuy Mai; Abadir, Sylvia; Nuyt, Anne‐Monique

doi:10.1038/s41390-020-0814-9

Cited by 5 publications

(14 citation statements)

References 39 publications

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“…Along the same line, none of the perinatal characteristics (at birth, or during neonatal stay) explored was associated with any change in QTc in former ELBW cases. 7 Finally, we confirmed the observation of Gervais of a modest increase (+8 beats per minute, bpm in their study) in heart rate in former preterms at rest, be that the difference in the PREMATCH study (+4 bpm) did not reach statistical significance (Table 1). 7 So, in essence we confirm the absence of a difference in QTc in a somewhat younger (9-14 years) cohort of former ELBW cases.…”

Section: Discussionsupporting

confidence: 87%

“…Whether preterm birth is associated with conduction or repolarization abnormalities later in life is less well explored. 7 At present, there are conflicting data on the potential QT interval prolongation in former extreme low birth weight (ELBW, <1000 g) infants. [7][8][9][10] On the one hand, Bassareo et al 8 reported that corrected QT (QTc) intervals and QT dispersion (QTd) were significantly prolonged in 24 former ELBW cases compared to 24 term controls (mean, ±SD: 417, 23.6 versus 369, 19.5 ms, and 30.4, 14.1 versus 24.6, 8.2 ms, respectively).…”

Section: Introductionmentioning

confidence: 99%

“…7 At present, there are conflicting data on the potential QT interval prolongation in former extreme low birth weight (ELBW, <1000 g) infants. [7][8][9][10] On the one hand, Bassareo et al 8 reported that corrected QT (QTc) intervals and QT dispersion (QTd) were significantly prolonged in 24 former ELBW cases compared to 24 term controls (mean, ±SD: 417, 23.6 versus 369, 19.5 ms, and 30.4, 14.1 versus 24.6, 8.2 ms, respectively). Gervais et al 7 could subsequently not confirm these findings in 49 preterm cases (<30 weeks gestational age) when compared to 53 term born controls.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 Finally, a study comparing QTc and QTd intervals between full term born cases with either a low birth weight (n = 50) or normal weight (n = 70) at an average age of 10 years could neither document significant differences. 11 Although the majority of the previously mentioned ECG studies were conducted at young adulthood (23.2, ±3.3 years and 18-33 years respectively), 7,8 we considered that the ECG observations, collected as part of the PREMATurity as predictor of children's Cardiovascular-renal Health (PREMATCH) study in former ELBW cases or term controls collected during pre-adolescence (age range 8-14 years) contribute to the available data on this specific aspect in former ELBW cases. 12…”

Section: Introductionmentioning

confidence: 99%

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QTc intervals are not prolonged in former ELBW infants at pre-adolescent age

et al. 2021

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BACKGROUND: Whether preterm birth is associated with cardiac conduction or repolarization abnormalities in later life is still poorly explored, with conflicting data on QTc prolongation in former extreme low birth weight (ELBW, <1000 g) infants. METHODS: Twelve lead electrocardiograms (ECG) at rest, collected in the PREMATurity as predictor of children's Cardiovascularrenal Health (PREMATCH) study in former ELBW cases and term controls during pre-adolescence (8-14 years) were analyzed on corrected QT time (QTc, Bazett) and QT dispersion (QTd). ECG findings were compared between groups (Mann−Whitney), and associations with clinical and biochemical findings were explored (Spearman). In ELBW cases, associations between QTc and perinatal characteristics (at birth, neonatal stay) were explored (Mann−Whitney, Spearman). RESULTS: QTc and QTd were similar between 93 ELBW cases and 87 controls [409 (range 360-465) versus 409 (337-460); 40 (0-100) versus 39 (0-110)] ms. Age, height, weight, or body mass index were not associated with the QTc interval, while female sex (median difference 11.4 ms) and lower potassium (r = −0.26) were associated with longer QTc interval. We could not observe any significant association between QTc interval and perinatal characteristics. CONCLUSIONS: There were no differences in QTc or QTd between ELBW and term controls in ECGs at rest in pre-adolescents.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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QTc intervals are not prolonged in former ELBW infants at pre-adolescent age

et al. 2021

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“…We found no evidence of intermittent hypoxia that could explain our findings. We previously reported the absence of ECG changes during exercise in a subset of term and preterm participants from the HAPI study who performed exercise testing and had continuous electrocardiographic and pulse oximetry monitoring 29. Pulse oximetry was ≥95% at baseline in all participants.…”

Section: Discussionmentioning

confidence: 88%

Duration of neonatal oxygen supplementation, erythropoiesis and blood pressure in young adults born preterm

Flahault

Girard‐Bock

Fernandes

et al. 2020

Thorax

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BackgroundAlthough erythropoiesis is impaired and anaemia frequent in neonates born preterm, haematopoiesis in adults born preterm has not been previously studied.ObjectiveWe, thus, aimed to evaluate haemoglobin and erythropoietin levels in young adults born preterm, to identify neonatal events associated with erythropoiesis in adulthood and to examine the relationships of haemoglobin levels with respiratory function and blood pressure.MethodsWe assessed a cohort of 101 young adults (ages 18–29) born preterm (≤29 weeks of gestation), in comparison to 105 full-term controls. We measured haemoglobin, erythropoietin levels and blood pressure. We also assessed respiratory function using spirometry.ResultsCompared with controls, tobacco use and sex-adjusted haemoglobin levels were 5.3 (95% CI 2.9 to 7.7) g/L higher in preterm-born individuals, but erythropoietin levels were similar. Duration of oxygen supplementation in the neonatal period was independently associated with higher haemoglobin levels in the preterm group. In young adults born preterm with bronchopulmonary dysplasia, airflow limitation was associated with higher haemoglobin levels. Both systolic (SBP) and diastolic (DBP) blood pressure were increased in individuals born preterm (p=0.042 and p=0.0008, respectively). Higher haemoglobin levels were associated with higher SBP and DBP, independently of term or preterm status. Mediation analysis suggests that haemoglobin increase contributes to 37% and 32% of the effect of preterm birth on SBP and DBP, respectively.ConclusionsHaemoglobin levels are higher in young adults born preterm, while erythropoietin levels are similar, especially in case of bronchopulmonary dysplasia and airflow limitation, and haemoglobin increase is associated with elevated blood pressure in this population.

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The QTc-Bazett Interval in Former Very Preterm Infants in Adolescence and Young Adulthood is Not Different from Term-Born Controls

et al. 2023

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Introduction Although relevant for precision pharmacovigilance, there are conflicting data on whether former preterm birth is associated with QT c-Bazett prolongation in later life. Methods To explore QT c-Bazett interval differences between former preterm and/or extremely low birth weight (ELBW) cases and term-born controls in adolescence and young adulthood, we analyzed pooled individual data after a structured search on published cohorts. To test the absence of a QT c-Bazett difference, a non-inferiority approach was applied (one-sided, upper limit of the 95% confidence interval [CI] mean QT c-Bazett difference, 5 and 10 ms). We also investigated the impact of characteristics, either perinatal or at assessment, on QT c-Bazett in the full dataset (cases and controls). Data were reported as median and range. Results The pooled dataset contained 164 former preterm and/or ELBW (cases) and 140 controls born full-term from three studies. The median QT c-Bazett intervals were 409 (335–490) and 410 (318–480) ms in cases and controls. The mean QT c-Bazett difference was 1 ms, with an upper 95% CI of 6 ms ( p > 0.05 and p < 0.01 for 5 and 10 ms, respectively). In the full dataset, females had a significantly longer QT c-Bazett than males (415 vs. 401 ms; p < 0.0001). Conclusions QT c-Bazett intervals are not significantly different between former preterm and/or ELBW cases and term-born controls, and we rejected a potential prolongation > 10 ms in cases. When prescribing QTc-prolonging drugs, pharmacovigilance practices in this subpopulation should be similar to the general public (NCT05243537). Supplementary Information The online version contains supplementary material available at 10.1007/s40264-023-01335-y.

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Electrocardiographic features at rest and during exercise in young adults born preterm below 30 weeks of gestation

Cited by 5 publications

References 39 publications

QTc intervals are not prolonged in former ELBW infants at pre-adolescent age

QTc intervals are not prolonged in former ELBW infants at pre-adolescent age

Duration of neonatal oxygen supplementation, erythropoiesis and blood pressure in young adults born preterm

The QTc-Bazett Interval in Former Very Preterm Infants in Adolescence and Young Adulthood is Not Different from Term-Born Controls

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